Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Marja, Ekblom"'
Autor:
Pingnan Xiao, Lakshmi Sandhow, Yaser Heshmati, Makoto Kondo, Thibault Bouderlique, Monika Dolinska, Anne-Sofie Johansson, Mikael Sigvardsson, Marja Ekblom, Julian Walfridsson, Hong Qian
Publikováno v:
Blood Advances, Vol 2, Iss 12, Pp 1480-1494 (2018)
Abstract: Despite increasing evidence for the involvement of bone marrow (BM) hematopoietic stem cell niche in leukemogenesis, how BM mesenchymal stem and progenitor cells (MSPCs) contribute to leukemia niche formation and progression remains unclear
Externí odkaz:
https://doaj.org/article/d16b6fbca23044788d0ecef25d309a60
Autor:
Monika Dolinska, Huan Cai, Alma Mansson, Jingyi Shen, Pingnan Xiao, Thibault Bouderlique, Xidan Li, Elory Leonard, Marcus Chang, Yuchen Gao, Juan Pablo Medina Giménez, Makoto Kondo, Lakshmi Sandhow, Anne-Sofie Johansson, Stefan Deneberg, Stina Söderlund, Martin Jädersten, Johanna S Ungerstedt, Magnus Tobiasson, Arne Östman, Satu Mustjoki, Leif Stenke, Katarina Le Blanc, Eva S Hellstrom-Lindberg, Sören Lehmann, Marja Ekblom, Ulla Olsson-Strömberg, Mikael Sigvardsson, Hong Qian
Publikováno v:
Blood.
Although tyrosine kinase inhibitors are effective for treating chronic myeloid leukemia (CML), they often fail to eradicate the leukemia-initiating stem cells (LSCs), causing disease persistence and relapse. Evidence indicates that LSC persistence ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ab4930ee1ab1d3b49c957490bdc6c07
https://doi.org/10.1182/blood.2022016896
https://doi.org/10.1182/blood.2022016896
Autor:
Hongzhe Li, Roshanak Ghazanfari, Dimitra Zacharaki, Nicholas Ditzel, Joan Isern, Marja Ekblom, Simón Méndez-Ferrer, Moustapha Kassem, Stefan Scheding
Publikováno v:
Stem Cell Reports, Vol 3, Iss 6, Pp 965-974 (2014)
Human bone marrow (BM) contains a rare population of nonhematopoietic mesenchymal stromal cells (MSCs), which are of central importance for the hematopoietic microenvironment. However, the precise phenotypic definition of these cells in adult BM has
Externí odkaz:
https://doaj.org/article/72210011abe144f1a889606746a5fbe7
Autor:
Huan, Cai, Makoto, Kondo, Lakshmi, Sandhow, Pingnan, Xiao, Anne-Sofie, Johansson, Takako, Sasaki, Joanna, Zawacka-Pankau, Karl, Tryggvason, Johanna, Ungerstedt, Julian, Walfridsson, Marja, Ekblom, Hong, Qian
Publikováno v:
Blood. 139(20)
Impairment of normal hematopoiesis and leukemia progression are 2 well-linked processes during leukemia development and are controlled by the bone marrow (BM) niche. Extracellular matrix proteins, including laminin, are important BM niche components.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::37f3470d951ca9ef28b82c388f8ef9c2
https://pubmed.ncbi.nlm.nih.gov/34958665
https://pubmed.ncbi.nlm.nih.gov/34958665
Autor:
Julian Walfridsson, Makoto Kondo, Yaser Heshmati, Pingnan Xiao, Lakshmi Sandhow, Mikael Sigvardsson, Hong Qian, Marja Ekblom, Monika Dolinska, Anne-Sofie Johansson, Thibault Bouderlique
Despite increasing evidence for the involvement of bone marrow (BM) hematopoietic stem cell niche in leukemogenesis, how BM mesenchymal stem and progenitor cells (MSPCs) contribute to leukemia niche formation and progression remains unclear. Using an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2d6903268f8903edad731c7eebcbab
https://europepmc.org/articles/PMC6020803/
https://europepmc.org/articles/PMC6020803/
Autor:
Anne Johansson, Satu Mustjoki, Marja Ekblom, Pingnan Xiao, Johannis Klang, Wan Man Wong, Elham Yektaei-Karin, Hong Qian, Eleni Gelali, Alexandre Piccini, Monika Dolinska, Ulla Olsson Strömberg, Leif Stenke
Tyrosine kinase inhibitors targeting the BCR-ABL oncoprotein in chronic myeloid leukemia (CML) are remarkably effective inducing deep molecular remission in most patients. However, they are less effective to eradicate the leukemic stem cells (LSC), r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148588c58de35afe1fa579d2928e5a3b
http://hdl.handle.net/10138/217891
http://hdl.handle.net/10138/217891
Autor:
Monika, Dolinska, Alexandre, Piccini, Wan Man, Wong, Eleni, Gelali, Anne-Sofie, Johansson, Johannis, Klang, Pingnan, Xiao, Elham, Yektaei-Karin, Ulla Olsson, Strömberg, Satu, Mustjoki, Leif, Stenke, Marja, Ekblom, Hong, Qian
Publikováno v:
Biochemical and biophysical research communications. 490(2)
Tyrosine kinase inhibitors targeting the BCR-ABL oncoprotein in chronic myeloid leukemia (CML) are remarkably effective inducing deep molecular remission in most patients. However, they are less effective to eradicate the leukemic stem cells (LSC), r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b4d70d1ac79114e2ac60307df524bdd0
https://pubmed.ncbi.nlm.nih.gov/28623130
https://pubmed.ncbi.nlm.nih.gov/28623130
Autor:
Anders Nilsson, Lena Kanter, Barbro Näsman-Glaser, Jonas Wallvik, Marja Ekblom, Monika Dolinska, Leif Stenke, Ana Zovko, Elham Yektaei-Karin, Hong Qian, Olof Rådmark
Publikováno v:
Leukemialymphoma. 58(8)
Although tyrosine kinase inhibitors (TKIs) have dramatically improved clinical outcome in chronic myeloid leukemia (CML), cure rarely occurs. This may be due to BCR-ABL-independent, aberrant signaling pathways, one of which leads to leukotriene (LT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a24b228dba3317028cf2ae19931987e
https://pubmed.ncbi.nlm.nih.gov/27931141
https://pubmed.ncbi.nlm.nih.gov/27931141
Autor:
Ingbritt Åstrand-Grundström, Mikael Sigvardsson, Jonas Larsson, Wan Man Wong, Donna E. Hogge, Marja Ekblom, Hong Qian
Publikováno v:
Stem Cells. 31:360-371
Human hematopoietic stem cells reside in the CD34+CD38−CD90+ population in cord blood and bone marrow. However, this cell fraction is heterogeneous, and the phenotype of the rare primitive stem cells remains poorly defined. We here report that prim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac5fd0ceeca573fe81a66514bcba574
https://doi.org/10.1002/stem.1282
https://doi.org/10.1002/stem.1282
Autor:
Ingbritt Åstrand-Grundström, Henrik Hjorth-Hansen, Hanna Rajala, Inger Haulin, Birgitte Ravn Juhl, Ole Weis Bjerrum, Ulla Olsson-Strömberg, Satu Mustjoki, Ellen Rabben Svedahl, Kimmo Porkka, Ahmed Al-Samadi, Mohamed El Missiry, Marja Ekblom, Maren Wold, Berit Markevän, Shady Adnan Awad
Publikováno v:
Journal of cancer research and clinical oncology. 142(5)
Tyrosine kinase inhibitors (TKIs) used in the treatment of chronic myeloid leukaemia have been reported to induce immunomodulatory effects. We aimed to assess peripheral blood (PB) and bone marrow (BM) lymphocyte status at the diagnosis and during di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39df0d9368cec1c48d149921b74ddb18
https://pubmed.ncbi.nlm.nih.gov/26746653
https://pubmed.ncbi.nlm.nih.gov/26746653