Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Mariya Morar"'
Autor:
Ilean Chai, Dmytro Kornyeyev, Edward Hsieh, Gesham Magombedze, Lance Stapleton, Magdeleine Hung, Hyock Joo Kwon, Erin Stefanutti, JeanPhilippe Belzile, Gregg Czerwieniec, Adele Y. Wang, Mariya Morar, Latesh Lad
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) checkpoint blockade is central to Immuno-Oncology based therapies, and alternatives to antibody blockers of this interaction are an active area of research due to antibody relat
Externí odkaz:
https://doaj.org/article/852440356267466d840a0d3719af6b2a
Autor:
Malene L Urbanus, Andrew T Quaile, Peter J Stogios, Mariya Morar, Chitong Rao, Rosa Di Leo, Elena Evdokimova, Mandy Lam, Christina Oatway, Marianne E Cuff, Jerzy Osipiuk, Karolina Michalska, Boguslaw P Nocek, Mikko Taipale, Alexei Savchenko, Alexander W Ensminger
Publikováno v:
Molecular Systems Biology, Vol 12, Iss 12, Pp n/a-n/a (2016)
Abstract Pathogens deliver complex arsenals of translocated effector proteins to host cells during infection, but the extent to which these proteins are regulated once inside the eukaryotic cell remains poorly defined. Among all bacterial pathogens,
Externí odkaz:
https://doaj.org/article/90c7ff684d7f4248a728c84036429cc9
Autor:
Ruth Wang, Sarah Wise, Ben Niu, Todd C. Appleby, Michael L. Gross, Melanie Wong, Giuseppe A. Papalia, Jean-Philippe Belzile, Sheila Clancy, Latesh Lad, Armando G. Villaseñor, Johannes Voight, Mariya Morar, Katherine M. Brendza
Publikováno v:
Biochemistry
Blocking interactions between PD-1 and PD-L1 opens a new era of cancer treatment involving immunity modulation. Although most immunotherapies use monoclonal antibodies, small-molecule inhibitors offer advantages. To facilitate development of small-mo
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 83:2319-2325
Legionella pneumophila, the intracellular pathogen that can cause severe pneumonia known as Legionnaire's disease, translocates close to 300 effectors inside the host cell using Dot/Icm type IVB secretion system. The structure and function for the ma
Autor:
Kalinka Koteva, Gerard D. Wright, Peter J. Stogios, Alexei Savchenko, Elena Evdokimova, Mariya Morar, Patrice Courvalin
Publikováno v:
Journal of Molecular Biology. 427:2229-2243
One of the main mechanisms of resistance to lincosamide and aminoglycoside antibiotics is their inactivation by O-nucleotidylyltransferases (NTases). Significant sequence variation of lincomycin nucleotidylyltransferase (Lnu) and aminoglycoside nucle
Autor:
Elena Evdokimova, Mikko Taipale, Jerzy Osipiuk, Chitong Rao, Alexander W. Ensminger, Malene L. Urbanus, Boguslaw Nocek, Mandy H. Y. Lam, Rosa Di Leo, Marianne E. Cuff, Alexei Savchenko, Andrew T. Quaile, Christina Oatway, Peter J. Stogios, Mariya Morar, Karolina Michalska
Publikováno v:
Molecular Systems Biology. 12
Pathogens deliver complex arsenals of translocated effector proteins to host cells during infection, but the extent to which these proteins are regulated once inside the eukaryotic cell remains poorly defined. Among all bacterial pathogens, Legionell
Autor:
Gerard D. Wright, Jonathan S O'Brien, Patricia L. Taylor, Irene Tang, Marie Yan, Arlene D. Sutherland, Lindsay Kalan, Wenliang Wang, Andrew C. Pawlowski, Mariya Morar, Maulik N. Thaker, Kirandeep Bhullar, Gianfranco De Pascale, Michael R. Mulvey, Marc J. Canova, Nicholas Waglechner, Fazmin Nizam, Marisa A. Azad, Andrew M. King, Kalinka Koteva, Linda Ejim, Peter Spanogiannopoulos, Andrew G. McArthur, Laura J. V. Piddock, Alison J. Baylay, Austin Yan, Tennison Yu
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:3348-3357
The field of antibiotic drug discovery and the monitoring of new antibiotic resistance elements have yet to fully exploit the power of the genome revolution. Despite the fact that the first genomes sequenced of free living organisms were those of bac
Autor:
Thomas Hauch Fenger, Nicolas Lenfant, Alexei Savchenko, Elena Evdokimova, Peter J. Stogios, Xiaohui Xu, Hong Cui, Bernard Henrissat, Nicholas McGregor, Mariya Morar, Victor Yin, Harry Brumer
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (3), pp.1175-1197. ⟨10.1074/jbc.M115.691659⟩
Journal of Biological Chemistry, 2016, 291 (3), pp.1175-1197. ⟨10.1074/jbc.M115.691659⟩
Journal of Biological Chemistry 3 (291), 1175-1197. (2016)
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (3), pp.1175-1197. ⟨10.1074/jbc.M115.691659⟩
Journal of Biological Chemistry, 2016, 291 (3), pp.1175-1197. ⟨10.1074/jbc.M115.691659⟩
Journal of Biological Chemistry 3 (291), 1175-1197. (2016)
The recent classification of glycoside hydrolase family 5 (GH5) members into subfamilies enhances the prediction of substrate specificity by phylogenetic analysis. However, the small number of well characterized members is a current limitation to und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67afb4393fe69b4d3f9bbb7d26b7f0ca
https://hal.archives-ouvertes.fr/hal-01439074
https://hal.archives-ouvertes.fr/hal-01439074
Autor:
Vanessa M. D'Costa, Hendrik N. Poinar, Wilson W L Sung, Régis Debruyne, Mariya Morar, Fabrice Calmels, Carsten Schwarz, G. Brian Golding, Grant D. Zazula, Lindsay Kalan, Duane G. Froese, Christine E. King, Gerard D. Wright
Publikováno v:
Nature. 477:457-461
The discovery of antibiotics more than 70 years ago initiated a period of drug innovation and implementation in human and animal health and agriculture. These discoveries were tempered in all cases by the emergence of resistant microbes. This history
Autor:
Gerard D. Wright, Mariya Morar
Publikováno v:
Annual Review of Genetics. 44:25-51
The need for new antibiotic therapies is acute and growing in large part because of the emergence of drug-resistant pathogens. A vast number of resistance determinants are, however, found in nonpathogenic micro-organisms. The resistance totality in t