Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Mariya I. Meschaninova"'
Publikováno v:
Molecules, Vol 29, Iss 13, p 3225 (2024)
A short 19 bp dsRNA with 3′-trinucleotide overhangs acting as immunostimulating RNA (isRNA) demonstrated strong antiproliferative action against cancer cells, immunostimulatory activity through activation of cytokines and Type-I IFN secretion, as w
Externí odkaz:
https://doaj.org/article/c6aabba104144e50b02e58a6ee79e1f2
Autor:
Ivan V. Chernikov, Irina K. Bachkova, Aleksandra V. Sen’kova, Mariya I. Meschaninova, Innokenty A. Savin, Valentin V. Vlassov, Marina A. Zenkova, Elena L. Chernolovskaya
Publikováno v:
Cells, Vol 13, Iss 9, p 767 (2024)
Small interfering RNA (siRNA) holds significant therapeutic potential by silencing target genes through RNA interference. Current clinical applications of siRNA have been primarily limited to liver diseases, while achievements in delivery methods are
Externí odkaz:
https://doaj.org/article/df86cd36ee1a45d0b8013056b41765d0
Autor:
Ivan V. Chernikov, Ul’yana A. Ponomareva, Mariya I. Meschaninova, Irina K. Bachkova, Valentin V. Vlassov, Marina A. Zenkova, Elena L. Chernolovskaya
Publikováno v:
Molecules, Vol 29, Iss 4, p 786 (2024)
Cholesterol siRNA conjugates attract attention because they allow the delivery of siRNA into cells without the use of transfection agents. In this study, we compared the efficacy and duration of silencing induced by cholesterol conjugates of selectiv
Externí odkaz:
https://doaj.org/article/a9812619882e4165812a0c26a5a07816
Publikováno v:
Molecules, Vol 28, Iss 4, p 1904 (2023)
One of the key problems in the design of therapeutic and diagnostic oligonucleotides is the attachment of small-molecule ligands for targeted deliveries in such a manner that provides the controlled release of the oligonucleotide at a certain moment.
Externí odkaz:
https://doaj.org/article/2a43c218202a4b40859e4c3ae7ae0e59
Autor:
Ivan V. Chernikov, Daniil V. Gladkikh, Mariya I. Meschaninova, Alya G. Ven'yaminova, Marina A. Zenkova, Valentin V. Vlassov, Elena L. Chernolovskaya
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 6, Iss , Pp 209-220 (2017)
Chemical modifications are an effective way to improve the therapeutic properties of small interfering RNAs (siRNAs), making them more resistant to degradation in serum and ensuring their delivery to target cells and tissues. Here, we studied the car
Externí odkaz:
https://doaj.org/article/a745375785e3445691e0772e40b58dd1
Publikováno v:
Molecules, Vol 26, Iss 8, p 2119 (2021)
One of the ways to efficiently deliver various drugs, including therapeutic nucleic acids, into the cells is conjugating them with different transport ligands via labile or stable bonds. A convenient solid-phase approach for the synthesis of 5′-con
Externí odkaz:
https://doaj.org/article/fd1bdcb4185f4aba81749ca16b476222
Autor:
Ivan V. Chernikov, Daniil V. Gladkikh, Ulyana A. Karelina, Mariya I. Meschaninova, Alya G. Ven’yaminova, Valentin V. Vlassov, Elena L. Chernolovskaya
Publikováno v:
Molecules, Vol 25, Iss 8, p 1877 (2020)
Cholesterol derivatives of nuclease-resistant, anti-MDR1 small-interfering RNAs were designed to contain a 2’-OMe-modified 21-bp siRNA and a 63-bp TsiRNA in order to investigate their accumulation and silencing activity in vitro and in vivo. The re
Externí odkaz:
https://doaj.org/article/9855b7ac768443a4983228cea32b11ab
Autor:
Darya S. Novopashina, Maya A. Dymova, Anna S. Davydova, Mariya I. Meschaninova, Daria O. Malysheva, Elena V. Kuligina, Vladimir A. Richter, Iaroslav A. Kolesnikov, Sergey Yu. Taskaev, Mariya A. Vorobyeva
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 1; Pages: 306
Among the great variety of anti-cancer therapeutic strategies, boron neutron capture therapy (BNCT) represents a unique approach that doubles the targeting accuracy due to the precise positioning of a neutron beam and the addressed delivery of boron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f1d2173023789095d5520bb1716e90
Autor:
D. S. Novopashina, E. A. Akhmetova, Alya G. Venyaminova, Victor M. Golyshev, I. P. Vokhtantcev, Mariya I. Meschaninova
Publikováno v:
Russian Journal of Bioorganic Chemistry. 47:496-504
A photoactivatable CRISPR/Cas9 system consisting of the Cas9 protein, synthetic 102-nt sgRNA or a pair of guide crRNA/tracrRNA, and blocking photocleavable oligodeoxyribonucleotides has been designed. Photocleavable oligodeoxyribonucleotides contain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b939d3d2e21820b5809354bc93aedd56
https://doi.org/10.1134/s1068162021020023
https://doi.org/10.1134/s1068162021020023
Autor:
Alya G. Venyaminova, Mariya I. Meschaninova, V. A. Gvozdev, Marina A. Zenkova, O. A. Patutina, O. N. Gusachenko, Valentin V. Vlassov
Publikováno v:
Russian Journal of Bioorganic Chemistry. 45:739-748
The development of highly effective molecular and biological tools to facilitate the penetration of therapeutic nucleic acids into cells opens a direct way to their successful application as drugs. It has been shown that the incorporation of single-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::498cddfc94d6bddfdef3a0ace5e3650f
https://doi.org/10.1134/s1068162019060177
https://doi.org/10.1134/s1068162019060177