Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mariya D. Kolesnikova"'
Autor:
Kelly J. Fitzgerald, David Spiegel, Aaron Balog, Weifang Shan, Andrew Zhang, Eugene F. Douglass, Mariya D. Kolesnikova, Patrick J. McEnaney
Publikováno v:
Journal of the American Chemical Society
This article reports the design, synthesis, and evaluation of a novel class of molecules of intermediate size (approximately 7000 Da), which possess both the targeting and effector functions of antibodies. These compounds—called synthetic antibody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc237312d8922031fc7c3e8f807cb08
https://doi.org/10.1021/ja509513c
https://doi.org/10.1021/ja509513c
Autor:
Mariya D. Kolesnikova, Rachel P. Berger, Janet Fromkin, Bruce E. Herman, Mary Clyde Pierce, Paul T. Smith, David Englert, Richard A. Saladino, Patrick M. Kochanek, Brian J. Pak
Publikováno v:
JAMA pediatrics. 171(6)
Importance Abusive head trauma is the leading cause of death from physical abuse. Missing the diagnosis of abusive head trauma, particularly in its mild form, is common and contributes to increased morbidity and mortality. Serum biomarkers may have p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a170897b73a8511b5b01c54061675be
https://pubmed.ncbi.nlm.nih.gov/28395008
https://pubmed.ncbi.nlm.nih.gov/28395008
Autor:
Nishat Zaman, Gabrielle Wishart, Arianna Hustler, David Englert, Mariya D. Kolesnikova, Daniel J. O'Shannessy
Publikováno v:
Cancer Research. 79:1375-1375
Background: Discrimination between benign and malignant pelvic masses by gene expression profiling of circulating tumor cells (CTCs) may provide information to assist in treatment decisions and improve outcomes. CTCs can be isolated and harvested fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08e1ce917cbfd379014c958d6b6c1f74
https://doi.org/10.1158/1538-7445.am2019-1375
https://doi.org/10.1158/1538-7445.am2019-1375
Autor:
David Spiegel, Christopher G. Parker, Eugene F. Douglass, Ran N. Tao, Mariya D. Kolesnikova, Charles E. Jakobsche
Publikováno v:
ACS Chemical Biology. 8:2404-2411
The ability to profile the prevalence and functional activity of endogenous antibodies is of vast clinical and diagnostic importance. Serum antibodies are an important class of biomarkers and are also crucial elements of immune responses elicited by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35fb7ed16830f9318458b8445d758228
https://doi.org/10.1021/cb4004942
https://doi.org/10.1021/cb4004942
Publikováno v:
Journal of the American Chemical Society. 135:5885-5894
Plants allocate an estimated 15-25% of their proteome to specialized metabolic pathways that remain largely uncharacterized. Here, we describe a genome mining strategy for exploring such unknown pathways and demonstrate this approach for triterpenoid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf58d2f220dc6511e0c58230a24e778
https://doi.org/10.1021/ja401535g
https://doi.org/10.1021/ja401535g
Autor:
Quanbo Xiong, Aparna Bhaduri, William K. Wilson, Mariya D. Kolesnikova, Seiichi P. T. Matsuda, Diana Sttivend, Pietro Morlacchi
Publikováno v:
Organic Letters. 11:2627-2630
The triterpene product profile is reported for At5g36150 (PEN3), the last unexamined oxidosqualene cyclase in the reference plant Arabidopsis thaliana. PEN3 makes tirucalla-7,24-dien-3beta-ol ( approximately 85%) and several minor products. Also disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8af256104b5298bc2ea00ea2fbfe33b
https://doi.org/10.1021/ol9005745
https://doi.org/10.1021/ol9005745
Autor:
Seiichi P. T. Matsuda, William K. Wilson, Mariya D. Kolesnikova, David A. Lynch, and Allie C. Obermeyer
Publikováno v:
Organic Letters. 9:5223-5226
We establish by heterologous expression that the Arabidopsis thaliana oxidosqualene cyclase At1g78955 (CAMS1) makes camelliol C (98%), achilleol A (2%), and beta-amyrin (0.2%). CAMS1 is the first characterized cyclase that generates predominantly a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbab8227dbc39d80e4c8d38ae92efc70
https://doi.org/10.1021/ol702399g
https://doi.org/10.1021/ol702399g
Autor:
Mariya D. Kolesnikova, Quanbo Xiong, Silvia Lodeiro, William K. Wilson, Carl S. Onak, Seiichi P. T. Matsuda
Publikováno v:
Journal of the American Chemical Society. 129:11213-11222
The genome of the model plant Arabidopsis thaliana encodes 13 oxidosqualene cyclases, 9 of which have been characterized by heterologous expression in yeast. Here we describe another cyclase, baruol synthase (BARS1), which makes baruol (90%) and 22 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23af11b6b07150254dd86fb06ef234b1
https://doi.org/10.1021/ja073133u
https://doi.org/10.1021/ja073133u
Autor:
Seiichi P. T. Matsuda, William K. Wilson, Quanbo Xiong, Mariya D. Kolesnikova, Allie C. Obermeyer, David A. Lynch
Publikováno v:
Organic Letters. 9:2183-2186
An oxidosqualene cyclase from Arabidopsis thaliana makes arabidiol, a tricyclic triterpene reported with indeterminate side-chain stereochemistry. We established the full structure of arabidiol through chemical degradation, NOE experiments, and molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e622fa078aebf212ef71d108c4ffb2e
https://doi.org/10.1021/ol070709b
https://doi.org/10.1021/ol070709b
Publikováno v:
Archives of Biochemistry and Biophysics. 447:87-95
Plants biosynthesize sterols from cycloartenol using a pathway distinct from the animal and fungal route through lanosterol. Described herein are genome-mining experiments revealing that Arabidopsis encodes, in addition to cycloartenol synthase, an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b07e2b5f985ec0e8199e7ea02e9245
https://doi.org/10.1016/j.abb.2005.12.010
https://doi.org/10.1016/j.abb.2005.12.010