Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Mariusz W. Szkudlinski"'
Autor:
Mariusz W. Szkudlinski
Publikováno v:
Frontiers in Endocrinology, Vol 6 (2015)
Last two decades of structure-function studies performed in numerous laboratories provided substantial progress in understanding basic science, physiological, pathophysiological, pharmacological and comparative aspects of glycoprotein hormones (GPHs)
Externí odkaz:
https://doaj.org/article/e620c81749674d7e98a165615dddce71
Autor:
Bryan Faust, Christian B. Billesbølle, Carl-Mikael Suomivuori, Isha Singh, Kaihua Zhang, Nicholas Hoppe, Antonio F. M. Pinto, Jolene K. Diedrich, Yagmur Muftuoglu, Mariusz W. Szkudlinski, Alan Saghatelian, Ron O. Dror, Yifan Cheng, Aashish Manglik
Publikováno v:
Nature, vol 609, iss 7928
Nature
Nature
Thyroid hormones are vital in metabolism, growth and development(1). Thyroid hormone synthesis is controlled by thyrotropin (TSH), which acts at the thyrotropin receptor (TSHR)(2). In patients with Graves’ disease, autoantibodies that activate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c970e589a202254df5f2423c80112e
https://escholarship.org/uc/item/7xj7c9w5
https://escholarship.org/uc/item/7xj7c9w5
Autor:
Armando Bartolazzi, Lajos Balogh, Isabella Manni, Michela Varani, Filippo Galli, Alberto Signore, Bruce D. Weintraub, Giuseppe Campagna, Chiara Lauri, Mariusz W. Szkudlinski, Giulia Piaggio
Publikováno v:
Journal of Clinical Medicine
Volume 10
Issue 9
Journal of Clinical Medicine, Vol 10, Iss 1878, p 1878 (2021)
Volume 10
Issue 9
Journal of Clinical Medicine, Vol 10, Iss 1878, p 1878 (2021)
Differentiated thyroid cancer (DTC) cells may lose NIS expression and iodine uptake, but usually express TSH receptors (TSHR). Therefore, the aim of our study was to compare two radiolabeled superagonist TSH analogues for DTC imaging. These analogues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8737c50665d7ff4b3509018c1052f52c
http://hdl.handle.net/11573/1589321
http://hdl.handle.net/11573/1589321
Autor:
Lutz Schomburg, Josef Köhrle, Laura Kalveram, Annette Grüters-Kieslich, Heike Biebermann, Mariusz W. Szkudlinski, Gunnar Kleinau
Publikováno v:
Molecular Endocrinology. 30:954-964
Naturally occurring thyrotropin (TSH) mutations are rare, which is also the case for the homologous heterodimeric glycoprotein hormones (GPHs) follitropin (FSH), lutropin (LH), and choriogonadotropin (CG). Patients with TSH-inactivating mutations pre
Autor:
Samanta Taurone, Enzo Agostinelli, Giulia Piaggio, Enrica Bianchi, Marco Artico, Mariusz W. Szkudlinski, Alberto Signore, Bruce D. Weintraub, Filippo Galli, Isabella Manni, Rudi Dierckx
Publikováno v:
International journal of oncology, 50(6), 2171-2179. SPANDIDOS PUBL LTD
Angiogenesis is the main process responsible for tumor growth and metastatization. The principal effector of such mechanism is the vascular endothelial growth factor (VEGF) secreted by cancer cells and other components of tumor microenvironment. Radi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ad882d764729f6dcaf2d0bc6cfbd74
https://research.rug.nl/en/publications/16f4e7d3-8f72-4e46-9885-13600d6cd300
https://research.rug.nl/en/publications/16f4e7d3-8f72-4e46-9885-13600d6cd300
Autor:
Bruce D. Weintraub, Torsten Kuwert, Martin G. Pomper, Valerie Fremont, Mariusz W. Szkudlinski, Simone Maschauer, Vladimir Wolf, Catherine A. Foss, Sridhar Nimmagadda, Olaf Prante, Julia Reinfelder
Publikováno v:
Thyroid. 21:783-792
Superagonist analogs of human thyroid-stimulating hormone (hTSH) may stimulate the uptake of (131)I-iodide and (18)F-fluorodeoxyglucose ((18)F-FDG) in thyroid carcinomas to a greater degree than hTSH. We herein report the potency and efficacy of two
Autor:
Jörg Schaarschmidt, Holger Jaeschke, Sandra Mueller, Robert Günther, Mariusz W. Szkudlinski, Ralf Paschke
Publikováno v:
Endocrinology. 152:3268-3278
In which ways the binding of the thyroid stimulating hormone to the extracellular domain of its receptor leads to activation of the thyroid-stimulating hormone receptor (TSHR) is currently only incompletely understood. It is known that TSH binding to
Autor:
Julia Reinfelder, Robert Stoehr, Valerie Fremont, Simone Maschauer, Mariusz W. Szkudlinski, Olaf Prante, Bruce D. Weintraub, Arndt Hartmann, Torsten Kuwert
Publikováno v:
Journal of Nuclear Medicine. 50:1364-1370
Dedifferentiation of thyroid carcinoma is accompanied by increased accumulation of the PET tracer (18)F-FDG. The molecular mechanisms responsible for this phenomenon are poorly understood. Therefore, we studied the regulation of (18)F-FDG uptake by t
Autor:
Sandra Mueller, Gerd Krause, Ralf Paschke, Holger Jaeschke, Mariusz W. Szkudlinski, Gunnar Kleinau
Publikováno v:
The journal of biological chemistry, 284: 16317-16324
Bovine TSH (bTSH) has a higher affinity to the human TSHR (hTSHR) and a higher signaling activity than human TSH (hTSH). The molecular reasons for these phenomena are unknown. Distinct negatively charged residues (Glu297, Glu303, and Asp382) in the h
Autor:
Mariusz W Szkudlinski
Publikováno v:
Expert Opinion on Pharmacotherapy. 5:2435-2440
In recent years, many new recombinant protein therapeutics have been developed and tested in clinical trials [1]. Current and future clinical uses of recombinant human thyroid-stimulating hormone (rhTSH; Thyrogen, Genzyme) in thyroid diseases are dis