Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Mariusz Skwarczyński"'
Autor:
Lantian Lu, Wei Yang Kong, Jiahui Zhang, Farrhana Firdaus, James W. Wells, Rachel J. Stephenson, Istvan Toth, Mariusz Skwarczynski, Jazmina L. Gonzalez Cruz
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Subunit vaccines hold substantial promise in controlling infectious diseases, due to their superior safety profile, specific immunogenicity, simplified manufacturing processes, and well-defined chemical compositions. One of the most important end-tar
Externí odkaz:
https://doaj.org/article/9d05d7bec5f34cd5a012036e2a7970cf
Publikováno v:
Viruses, Vol 16, Iss 5, p 757 (2024)
Coronavirus disease 2019 (COVID-19), the global pandemic caused by severe acute respiratory syndrome 2 virus (SARS-CoV-2) infection, has caused millions of infections and fatalities worldwide. Extensive SARS-CoV-2 research has been conducted to devel
Externí odkaz:
https://doaj.org/article/0d3c9ccb557447fca1fd526c30b6f04d
Autor:
Prashamsa Koirala, Ahmed O. Shalash, Sung-Po R. Chen, Mohammad O. Faruck, Jingwen Wang, Waleed M. Hussein, Zeinab G. Khalil, Robert J. Capon, Michael J. Monteiro, Istvan Toth, Mariusz Skwarczynski
Publikováno v:
Vaccines, Vol 12, Iss 2, p 198 (2024)
Mucosal vaccines are highly attractive due to high patient compliance and their suitability for mass immunizations. However, all currently licensed mucosal vaccines are composed of attenuated/inactive whole microbes, which are associated with a varie
Externí odkaz:
https://doaj.org/article/5a9c2bd3c5f744ec9d8faa3409c0b6d3
Publikováno v:
MedComm – Biomaterials and Applications, Vol 1, Iss 2, Pp n/a-n/a (2022)
Abstract Liver flukes, Opisthorchis viverrini, infect around 10 million individuals in Southeast Asia, alone, and cause 26,000 deaths in the region per year. Despite being classified as a Group 1 carcinogen, and presenting one of the leading causes o
Externí odkaz:
https://doaj.org/article/70d58db66fc4496298ec3c14f4ff05a2
Autor:
Md Tanjir Islam, Mei-Fong Ho, Ummey J Nahar, Ahmed O Shalash, Prashamsa Koirala, Waleed M Hussein, Danielle I Stanisic, Michael F Good, Mariusz Skwarczynski, Istvan Toth
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0264961 (2022)
Malaria is a vector born parasitic disease causing millions of deaths every year. Despite the high mortality rate, an effective vaccine against this mosquito-borne infectious disease is yet to be developed. Up to date, RTS,S/AS01 is the only vaccine
Externí odkaz:
https://doaj.org/article/d15f1b14b6f840d8a2f738faa11f9c0b
Autor:
Viet Tram Duong, Prashamsa Koirala, Sung-Po R. Chen, Michael J. Monteiro, Mariusz Skwarczynski, Istvan Toth
Publikováno v:
Molecules, Vol 28, Iss 5, p 2248 (2023)
Porcine circovirus 2 (PCV2) infection is one of the most serious threats to the swine industry. While the disease can be prevented, to some extent, by commercial PCV2a vaccines, the evolving nature of PCV2 necessitates the development of a novel vacc
Externí odkaz:
https://doaj.org/article/ce74b681deed49868d8156b7cb571adc
Autor:
Farrhana Z. Firdaus, Stacey Bartlett, Waleed M. Hussein, Lantian Lu, Quentin Wright, Wenbin Huang, Ummey J. Nahar, Jieru Yang, Mattaka Khongkow, Margaret Veitch, Prashamsa Koirala, Uracha R. Ruktanonchai, Michael J. Monteiro, Jazmina L. Gonzalez Cruz, Rachel J. Stephenson, James W. Wells, Istvan Toth, Mariusz Skwarczynski
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 602 (2023)
Human papilloma virus (HPV) is responsible for all cases of cervical cancer. While prophylactic vaccines are available, the development of peptide-based vaccines as a therapeutic strategy is still under investigation. In comparison with the tradition
Externí odkaz:
https://doaj.org/article/35974cd5d89e46b9a256e6e6ba570ed1
Autor:
Jieru Yang, Jennifer C. Boer, Mattaka Khongkow, Sarunya Phunpee, Zeinab G. Khalil, Sahra Bashiri, Cyril Deceneux, Georgia Goodchild, Waleed M. Hussein, Robert J. Capon, Uracha Ruktanonchai, Magdalena Plebanski, Istvan Toth, Mariusz Skwarczynski
Publikováno v:
Vaccines, Vol 11, Iss 2, p 305 (2023)
Intranasal vaccine administration can overcome the disadvantages of injectable vaccines and present greater efficiency for mass immunization. However, the development of intranasal vaccines is challenged by poor mucosal immunogenicity of antigens and
Externí odkaz:
https://doaj.org/article/646a8cd56d304937890b73924c2f122e
Publikováno v:
Bio-Protocol, Vol 11, Iss 7 (2021)
Most vaccines require co-delivery of an adjuvant in order to generate the desired immune responses. However, many currently available adjuvants are non-biodegradable, have limited efficacy, and/or poor safety profile. Thus, new adjuvants, or self-adj
Externí odkaz:
https://doaj.org/article/699524315b4a45a2bbb6eb7a4b32cdb1
Autor:
Stacey Bartlett, Mariusz Skwarczynski, Xin Xie, Istvan Toth, Alex Loukas, Ramon M Eichenberger
Publikováno v:
Precision Nanomedicine, Vol 3, Iss 1 (2020)
Peptide-based vaccines consist of short antigen fragments derived from a specific pathogen. Alone, these peptide fragments are poorly or non-immunogenic; however, when incorporated into a proper delivery system, they can trigger strong immune respons
Externí odkaz:
https://doaj.org/article/3a4014b997154e3b8972e26065666f3f