Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Mariusz Mucha"'
Autor:
Mariusz Mucha, Anna E. Skrzypiec, Jaison B. Kolenchery, Valentina Brambilla, Satyam Patel, Alberto Labrador-Ramos, Lucja Kudla, Kathryn Murrall, Nathan Skene, Violetta Dymicka-Piekarska, Agata Klejman, Ryszard Przewlocki, Valentina Mosienko, Robert Pawlak
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Severe psychological trauma triggers genetic, biochemical and morphological changes in amygdala neurons, which underpin the development of stress-induced behavioural abnormalities, such as high levels of anxiety. miRNAs are small, non-coding
Externí odkaz:
https://doaj.org/article/ed376b69ddf4449c9888ebefea91d3d4
Autor:
Jinwei Zhang, Mohammad Iqbal H. Bhuiyan, Ting Zhang, Jason K. Karimy, Zhijuan Wu, Victoria M. Fiesler, Jingfang Zhang, Huachen Huang, Md Nabiul Hasan, Anna E. Skrzypiec, Mariusz Mucha, Daniel Duran, Wei Huang, Robert Pawlak, Lesley M. Foley, T. Kevin Hitchens, Margaret B. Minnigh, Samuel M. Poloyac, Seth L. Alper, Bradley J. Molyneaux, Andrew J. Trevelyan, Kristopher T. Kahle, Dandan Sun, Xianming Deng
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
SPAK kinase is a master regulator of cation-Cl− cotransporters. Here the authors describe a new SPAK inhibitor with robust protective effects in rodent hydrocephalous and ischemic stroke models.
Externí odkaz:
https://doaj.org/article/3b3910c818a141759af3688133b30605
Autor:
Ibrahim Al-Osta, Mariusz Mucha, Daniel Pereda, Marta Piqué-Gili, Albert E. Okorocha, Roisin Thomas, Nicholas A. Hartell
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Externí odkaz:
https://doaj.org/article/4eb06e349c7c48d98ea7cbaf258ac360
Autor:
Ibrahim Al-Osta, Mariusz Mucha, Daniel Pereda, Marta Piqué-Gili, Albert E. Okorocha, Roisin Thomas, Nicholas A. Hartell
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Genetically encoded calcium indicators (GECIs) have gained widespread use for measurement of neuronal activity but their low expression levels in transgenic mice tend to limit sensitivity. We have developed a transgenic mouse line (SyG37) that expres
Externí odkaz:
https://doaj.org/article/8c475a202d444132a6b252cd76f247f6
Stress-induced lipocalin-2 controls dendritic spine formation and neuronal activity in the amygdala.
Autor:
Anna E Skrzypiec, Rahul S Shah, Emanuele Schiavon, Eva Baker, Nathan Skene, Robert Pawlak, Mariusz Mucha
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61046 (2013)
Behavioural adaptation to psychological stress is dependent on neuronal plasticity and dysfunction at this cellular level may underlie the pathogenesis of affective disorders such as depression and post-traumatic stress disorder. Taking advantage of
Externí odkaz:
https://doaj.org/article/7019906ecf1b4cf2b5903c3fabc7ed37
Autor:
Jamie J. Walker, Joël Tabak, Mariusz Mucha, Paul G. Winyard, Marziyeh Belal, Arnaud Monteil, Mino D. C. Belle, Robert Pawlak
The pituitary gland, the so-called master gland produces and secretes a variety of hormones essential for regulating growth and development, metabolic homeostasis, reproduction, and the stress response. The interplay between the brain and peripheral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4bdf2adda43535459d7ec86bddfcf43
https://doi.org/10.1101/2021.08.02.454810
https://doi.org/10.1101/2021.08.02.454810
Autor:
Lucja Wiktorowska, Marta Magnowska, Jakub Wlodarczyk, Izabela Figiel, Nobuo Nagai, Robert Pawlak, Barbara Pijet, Anna E. Skrzypiec, Mariusz Mucha, Leszek Kaczmarek, Rahul S. Shah, Benjamin K. Attwood, Agata Klejman, Yusuke Sakai, Jaison B. Kolenchery, Michal Swiatek, Ryszard Przewlocki, Valentina Brambilla, Malgorzata Bajor, Alberto Labrador-Ramos
Severe stress can trigger complex behavioural changes such as high anxiety (1). Inhibitory GABA-ergic interneurons in the lateral division of the central amygdala (CEl) control anxiety through feedforward inhibition of their target cells in the media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6496cbd187ca4a2e35a08e97a690b44f
https://doi.org/10.1101/2021.07.16.452595
https://doi.org/10.1101/2021.07.16.452595
Autor:
Robert Pawlak, Joanna Reszeć, Robert Chrzanowski, Mariusz Mucha, Violetta Dymicka-Piekarska, Joanna Kamińska, Anna Justyna Milewska, Marzena Tylicka, Olga M. Koper-Lenkiewicz, Joanna Matowicka-Karna, Ewa Matuszczak, Zenon Mariak, Karol Sawicki, Justyna Zińczuk
Publikováno v:
Annals of Medicine
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Taking into account the possibility of myelin-associated proteins having a role in brain tumour development, the study aimed to evaluate the diagnostic usefulness of myelin-associated proteins (Nogo-A, MAG, OMgp) released into extracellular space in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547d884709f8226acaa6666e5cf1b0bc
Autor:
Andrew H. Crosby, Mariusz Mucha, Meriel McEntagart, Emma L. Baple, Michael A. Simpson, Hamid Modarres, Ajith Sreekantan-Nair, Barry A. Chioza, Madhulika Kabra, Neerja Gupta, Michael A. Patton, Anthony C Pereira, Heather L. Moore-Barton, Christian Beetz, Sven Günther, Amir Jahic, Robert Pawlak, Gaurav V. Harlalka, Anna E. Skrzypiec, Seema Thakur, Richard C. Trembath
Publikováno v:
Human Mutation. 37:1157-1161
Hereditary spastic paraplegias (HSPs) are genetically and clinically heterogeneous axonopathies primarily affecting upper motor neurons and, in complex forms, additional neurons. Here, we report two families with distinct recessive mutations in TFG,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06ae65ec2a2e9599d5e76384ca87ea2b
https://doi.org/10.1002/humu.23060
https://doi.org/10.1002/humu.23060
Autor:
Jinwei, Zhang, Mohammad Iqbal H, Bhuiyan, Ting, Zhang, Jason K, Karimy, Zhijuan, Wu, Victoria M, Fiesler, Jingfang, Zhang, Huachen, Huang, Md Nabiul, Hasan, Anna E, Skrzypiec, Mariusz, Mucha, Daniel, Duran, Wei, Huang, Robert, Pawlak, Lesley M, Foley, T Kevin, Hitchens, Margaret B, Minnigh, Samuel M, Poloyac, Seth L, Alper, Bradley J, Molyneaux, Andrew J, Trevelyan, Kristopher T, Kahle, Dandan, Sun, Xianming, Deng
Publikováno v:
Nature Communications
The SLC12A cation-Cl− cotransporters (CCC), including NKCC1 and the KCCs, are important determinants of brain ionic homeostasis. SPAK kinase (STK39) is the CCC master regulator, which stimulates NKCC1 ionic influx and inhibits KCC-mediated efflux v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c9e39bcf3653515f6b08a66d7b98c4de
https://pubmed.ncbi.nlm.nih.gov/31911626
https://pubmed.ncbi.nlm.nih.gov/31911626