Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Mariusz Klobukowski"'
Publikováno v:
Molecules, Vol 27, Iss 13, p 3991 (2022)
Scoulerine is a natural compound that is known to bind to tubulin and has anti-mitotic properties demonstrated in various cancer cells. Its molecular mode of action has not been precisely known. In this work, we perform computational prediction and e
Externí odkaz:
https://doaj.org/article/ca42ed059bd3495f83ab2fc0be916af0
Autor:
Alicja Kuban-Jankowska, Magdalena Gorska, Jack A. Tuszynski, Cassandra D. M. Churchill, Philip Winter, Mariusz Klobukowski, Michal Wozniak
Publikováno v:
Cellular Physiology and Biochemistry, Vol 36, Iss 3, Pp 1069-1083 (2015)
Background/Aims: Protein tyrosine phosphatases are crucial enzymes controlling numerous physiological and pathophysiological events and can be regulated by oxidation of the catalytic domain cysteine residue. Peracids are highly oxidizing compounds, a
Externí odkaz:
https://doaj.org/article/f809817639ac42f7907393a705927769
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 6, p e1004313 (2015)
Microtubules are long filamentous hollow cylinders whose surfaces form lattice structures of αβ-tubulin heterodimers. They perform multiple physiological roles in eukaryotic cells and are targets for therapeutic interventions. In our study, we carr
Externí odkaz:
https://doaj.org/article/d7478414d1ba4da28ff54cb728ba4cc8
Autor:
Marc St George, Ahmed T Ayoub, Asok Banerjee, Cassandra D M Churchill, Philip Winter, Mariusz Klobukowski, Carol E Cass, Richard F Ludueña, Jack A Tuszynski, Sambasivarao Damaraju
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129168 (2015)
Our previous work identified an intermediate binding site for taxanes in the microtubule nanopore. The goal of this study was to test derivatives of paclitaxel designed to bind to this intermediate site differentially depending on the isotype of β-t
Externí odkaz:
https://doaj.org/article/f52f0efb56234a809812dbd19309eb40
Autor:
Ahmed Taha Ayoub, Michael Staelens, Alessio Prunotto, Marco A. Deriu, Andrea Danani, Mariusz Klobukowski, Jack Adam Tuszynski
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 10, p 2042 (2017)
Microtubules are the main components of mitotic spindles, and are the pillars of the cellular cytoskeleton. They perform most of their cellular functions by virtue of their unique dynamic instability processes which alternate between polymerization a
Externí odkaz:
https://doaj.org/article/4ef5225c62544fc8a3fdd01f4532f9e8
Autor:
Brayden Glockzin, Meagan S. Oakley, Abhoy Karmakar, Arkadii Pominov, Aaron A. Mitchell, Xiaochuan Ma, Mariusz Klobukowski, Vladimir K. Michaelis
Publikováno v:
The Journal of Physical Chemistry C. 127:7284-7298
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f336a837375c274ca15a40c8abececa
https://doi.org/10.1021/acs.jpcc.2c08073
https://doi.org/10.1021/acs.jpcc.2c08073
Autor:
Bozheng Sun, Meagan S. Oakley, Kota Yoshida, Yanwen Yang, Matteo Tommasini, Chiara Zanchi, Andrea Lucotti, Michael J. Ferguson, Frank Hampel, Mariusz Klobukowski, Rik R. Tykwinski
Cyclic tetraaryl[5]cumulenes (1 a-f) have been synthesized and studied as a function of increasing ring strain. The magnitude of ring strain is approximated by the extent of bending of the cumulenic core as assessed by a combination of X-ray crystall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c21225841fb81864aceffc9501f9191c
https://hdl.handle.net/11311/1223364
https://hdl.handle.net/11311/1223364
Cyclic tetraaryl[5]cumulenes (1a–f) have been synthesized and studied as a function of increasing ring strain. The magnitude of ring strain is approximated by the extent of bending of the cumulenic core as assessed by a combination of X-ray crystal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a7d8e47c953e17c2f6dac51ddbbb279
Autor:
Kenneth Flurchick, Leonid Gorb, Sujata Guha, Ivan Hubac, Mariusz Klobukowski, Jerzy Leszczynski, David C Young
Volume 3 of Computational Chemistry: Reviews of Current Trends adds well to the first two volumes of the series, presenting results of current developments in the methodologies and the applications of computational chemistry methods. The topics cover
Publikováno v:
Molecules; Volume 27; Issue 13; Pages: 3991
Scoulerine is a natural compound that is known to bind to tubulin and has anti-mitotic properties demonstrated in various cancer cells. Its molecular mode of action has not been precisely known. In this work we perform computational prediction and ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5007c5b30dd6354a649728d229a8bf21
https://doi.org/10.21203/rs.3.rs-500519/v1
https://doi.org/10.21203/rs.3.rs-500519/v1