Výsledky vyhledávání - "Mariusz Gutowski"

Systemic oxidative-nitrosative-inflammatory stress during acute exercise in hypoxia; implications for microvascular oxygenation and aerobic capacity

Autor: John Woodside, Lewis Fall, Mariusz Gutowski, Jane McEneny, Philip E. James, Damian M. Bailey, Shigehiko Ogoh, Ian S. Young

Publikováno v: Experimental Physiology. 99:1648-1662

New Findings: What is the central question of this study? Exercise performance is limited during hypoxia by a critical reduction in cerebral and skeletal tissue oxygenation. To what extent an elevation in systemic free radical accumulation contribute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c1fe102094256d56131c0dd7998eadd
https://doi.org/10.1113/expphysiol.2014.081265

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High-altitude pulmonary hypertension is associated with a free radical-mediated reduction in pulmonary nitric oxide bioavailability

Autor: Vitalie Faoro, Jane McEneny, Guido Schendler, Ian S. Young, Sarah Taudorf, Andrew M. Luks, Elmar Menold, Christoph Dehnert, Philip E. James, Marc M. Berger, Erik R. Swenson, Mariusz Gutowski, Heimo Mairbäurl, Christian Castell, Damian M. Bailey, Peter Bärtsch, Kevin A. Evans

Publikováno v: The Journal of Physiology. 588:4837-4847

High altitude (HA)-induced pulmonary hypertension may be due to a free radical-mediated reduction in pulmonary nitric oxide (NO) bioavailability. We hypothesised that the increase in pulmonary artery systolic pressure (PASP) at HA would be associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af99eae69c68f8af97987a596cb561f3
https://doi.org/10.1113/jphysiol.2010.194704

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Theoretical studies of l-ascorbic acid (vitamin C) and selected oxidised, anionic and free-radical forms

Autor: Mariusz Gutowski, William O. George, Damian M. Bailey

Publikováno v: Journal of Molecular Structure: THEOCHEM. 910:61-68

Calculations were carried out at the restricted and unrestricted B3LYP/6-311++G(d,p) and B3LYP/EPR-II levels for two conformers (1 and 2) of l -ascorbic acid and their respective oxidation products to di- and monodehydroascorbates. For the didehydroa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea0ce119b30f56260b76669e0c2c6d22
https://doi.org/10.1016/j.theochem.2009.06.016

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Altered free radical metabolism in acute mountain sickness: implications for dynamic cerebral autoregulation and blood-brain barrier function

Autor: Kirsten Møller, Damian M. Bailey, E Kewley, Philip E. James, Philip N. Ainslie, Ian S. Young, Joe M. McCord, Mariusz Gutowski, Kevin A. Evans, Lewis Fall, Jane McEneny

Publikováno v: The Journal of Physiology. 587:73-85

We tested the hypothesis that dynamic cerebral autoregulation (CA) and blood–brain barrier (BBB) function would be compromised in acute mountain sickness (AMS) subsequent to a hypoxia-mediated alteration in systemic free radical metabolism. Eightee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74f37e7b8f860aa2ab5c5d29c260522a
https://doi.org/10.1113/jphysiol.2008.159855

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Systemic oxidative-nitrosative-inflammatory stress during acute exercise in hypoxia; implications for microvascular oxygenation and aerobic capacity

Autor: John D S, Woodside, Mariusz, Gutowski, Lewis, Fall, Philip E, James, Jane, McEneny, Ian S, Young, Shigehiko, Ogoh, Damian M, Bailey

Publikováno v: Experimental physiology. 99(12)

Exercise performance in hypoxia may be limited by a critical reduction in cerebral and skeletal tissue oxygenation, although the underlying mechanisms remain unclear. We examined whether increased systemic free radical accumulation during hypoxia wou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1aac780d8e6e592bbeac9a493a5ebcca
https://pubmed.ncbi.nlm.nih.gov/25344270

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On the antioxidant properties of erythropoietin and its association with the oxidative–nitrosative stress response to hypoxia in humans

Autor: Kirsten Møller, C. W. Mulholland, Sylvia Pietri, Jane McEneny, Erik R. Swenson, Hidayat Rahmouni, Mariusz Gutowski, Jerome L. Sullivan, Marcel Culcasi, Bente Klarlund Pedersen, Damian M. Bailey, Carsten Lundby, Sarah Taudorf, Ian S. Young, Ronan M. G. Berg

Publikováno v: Acta Physiologica
Acta Physiologica, 2014, 212, pp.175. ⟨10.1111/apha.12313⟩
Acta Physiologica, Wiley, 2014, 212, pp.175. ⟨10.1111/apha.12313⟩

Aim: The aim of this study was to examine if erythropoietin (EPO) has the potential to act as a biological antioxidant and determine the underlying mechanisms. Methods: The rate at which its recombinant form (rHuEPO) reacts with hydroxyl (HO center d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c01e35cc846a847dc98148e2d0d456
https://amu.hal.science/hal-01142467

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A study of free radical chemistry: their role and pathophysiological significance

Autor: Mariusz Gutowski, Sławomir Kowalczyk

Publikováno v: Acta biochimica Polonica. 60(1)

Oxygen is one of the most important molecules on Earth mainly because of the biochemical symmetry of oxygenic photosynthesis and aerobic respiration that can maintain homeostasis within our planet's biosphere. Oxygen can also produce toxic molecules,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e47bf551373595f4b865f2b47ae5936
https://pubmed.ncbi.nlm.nih.gov/23513192

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