Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mariusz Bral"'
Autor:
Mariusz Bral, Rena Pawlick, Braulio Marfil-Garza, Nidheesh Dadheech, Joshua Hefler, Aducio Thiesen, A M James Shapiro
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0224567 (2019)
BACKGROUND:Liver ischemia reperfusion injury (IRI) remains a challenge in liver transplantation. A number of compounds have previously demonstrated efficacy in mitigating IRI. Herein, we applied three specific additive strategies to a mouse IRI scree
Externí odkaz:
https://doaj.org/article/30011a69f31944838f0cb63870e2fbaa
Autor:
Mariusz Bral, Nader Aboelnazar, Sanaz Hatami, Aducio Thiesen, David L Bigam, Darren H Freed, A M James Shapiro
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215619 (2019)
BackgroundOne of the most promising applications of liver normothermic machine perfusion (NMP) is the potential to directly assess graft viability and injury. In most NMP studies, perfusate transaminases are utilized as markers of graft injury. Our a
Externí odkaz:
https://doaj.org/article/e2907b56c8374317a70ab98bf2a7870b
Autor:
Juliet A. Emamaullee, Mariusz Bral, Glenda Meeberg, Aldo J. Montano-Loza, Vincent G. Bain, Kelly Warren Burak, David Bigam, A. M. James Shapiro, Norman Kneteman
Publikováno v:
Canadian Journal of Gastroenterology and Hepatology, Vol 2019 (2019)
Background. The introduction of direct-acting antivirals (DAA) for HCV has led to high rates of HCV eradication. Treatment of patients awaiting liver transplantation (LT) has been controversial. Recent data suggests that DAA treatment may accelerate
Externí odkaz:
https://doaj.org/article/525703fd71894c60896e4bc69ff48655
Autor:
A. M. James Shapiro, Mariusz Bral
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783030549169
Recent years have demonstrated a surging interest in normothermic ex situ liver perfusion, with iterative experimental and clinical studies establishing this technology as providing obvious advantages over static cold storage. In particular, the safe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1df769b0ab30acfb3ad14f8341b6a356
https://doi.org/10.1007/5584_2020_517
https://doi.org/10.1007/5584_2020_517
Publikováno v:
Transplantation Reviews. 32:132-141
In recent years, remarkable progress has occurred in the development of technologies to support ex situ liver perfusion. Building upon extensive preclinical studies in large animal models, pilot and randomized clinical trials have been initiated, and
Autor:
A. M. James Shapiro, Braulio A Marfil-Garza, Nidheesh Dadheech, Joshua Hefler, Mariusz Bral, Rena Pawlick, Aducio Thiesen
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 11, p e0224567 (2019)
PLoS ONE, Vol 14, Iss 11, p e0224567 (2019)
Background Liver ischemia reperfusion injury (IRI) remains a challenge in liver transplantation. A number of compounds have previously demonstrated efficacy in mitigating IRI. Herein, we applied three specific additive strategies to a mouse IRI scree
Autor:
Mariusz Bral, David L. Bigam, Juliet Emamaullee, A. M. James Shapiro, Norman M. Kneteman, Glenda Meeberg, Vincent G. Bain, Kelly W. Burak, Aldo J. Montano-Loza
Publikováno v:
Canadian Journal of Gastroenterology and Hepatology, Vol 2019 (2019)
Canadian Journal of Gastroenterology & Hepatology
Canadian Journal of Gastroenterology & Hepatology
Background. The introduction of direct-acting antivirals (DAA) for HCV has led to high rates of HCV eradication. Treatment of patients awaiting liver transplantation (LT) has been controversial. Recent data suggests that DAA treatment may accelerate
Autor:
Nasser Abualhassan, Rena Pawlick, Mariusz Bral, John Wink, Antonio Bruni, Boris Gala-Lopez, A. M. James Shapiro, Andrew R. Pepper, Yasmin Rafiei
Publikováno v:
Transplantation. 100:1474-1479
BACKGROUND Islet transplantation is a successful β-cell replacement therapy for selected patients with type 1 diabetes mellitus. However, despite early insulin independence, long-term graft attrition gradually reverts recipients to exogenous insulin
Autor:
Rena Pawlick, Nasser Abualhassen, Mariusz Bral, Antonio Bruni, Boris Gala-Lopez, A. M. James Shapiro, Yasmin Rafiei, Andrew R. Pepper, John Wink
Publikováno v:
Islets. 8:115-124
Quality of life in Type 1 diabetic patients may be improved with islet transplantation, but lifelong immunosuppression is required to prevent rejection. Allo-immune response is a key player in graft dysfunction and although the adaptive immune respon
Autor:
Patrick E. MacDonald, Nasser Abualhassan, Tatsuya Kin, Mariusz Bral, Lachlan G Young, Doug O’Gorman, A. M. J. Shapiro, Jocelyn E. Manning Fox, Andrew R. Pepper, Austin Bautista, Rena Pawlick, Antonio Bruni, Boris Gala-Lopez
Publikováno v:
Diabetes. 65:451-462
Clinical islet transplantation has become an established treatment modality for selected patients with type 1 diabetes. However, a large proportion of transplanted islets is lost through multiple factors, including immunosuppressant-related toxicity,