Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Mariusz Belka"'
Autor:
Claudia Musial, Narcyz Knap, Renata Zaucha, Paulina Bastian, Giampaolo Barone, Giosuè Lo Bosco, Fabrizio Lo-Celso, Lucyna Konieczna, Mariusz Belka, Tomasz Bączek, Antonella Marino Gammazza, Alicja Kuban-Jankowska, Francesco Cappello, Stephan Nussberger, Magdalena Gorska-Ponikowska
Publikováno v:
Redox Biology, Vol 55, Iss , Pp 102395- (2022)
Lung cancer is one of the most common cancers worldwide, causing nearly one million deaths each year. Herein, we present the effect of 2-methoxyestradiol (2-ME), the endogenous metabolite of 17β-estradiol (E2), on non-small cell lung cancer (NSCLC)
Externí odkaz:
https://doaj.org/article/499a3a75f7f3413b953812e55fd813a7
Autor:
Petar Žuvela, J. Jay Liu, Myunggi Yi, Paweł P. Pomastowski, Gulyaim Sagandykova, Mariusz Belka, Jonathan David, Tomasz Bączek, Krzysztof Szafrański, Beata Żołnowska, Jarosław Sławiński, Claudiu T. Supuran, Ming Wah Wong, Bogusław Buszewski
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1430-1443 (2018)
In this work, a target-based drug screening method is proposed exploiting the synergy effect of ligand-based and structure-based computer-assisted drug design. The new method provides great flexibility in drug design and drug candidates with consider
Externí odkaz:
https://doaj.org/article/10af111bcd05473b8f60c43ce8cbd7a1
Autor:
Beata Żołnowska, Jarosław Sławiński, Mariusz Belka, Tomasz Bączek, Anna Kawiak, Jarosław Chojnacki, Aneta Pogorzelska, Krzysztof Szafrański
Publikováno v:
Molecules, Vol 20, Iss 10, Pp 19101-19129 (2015)
A series of novel N-acyl-4-chloro-5-methyl-2-(R1-methylthio)benzenesulfonamides 18–47 have been synthesized by the reaction of N-[4-chloro-5-methyl-2-(R1-methylthio) benzenesulfonyl]cyanamide potassium salts with appropriate carboxylic acids. Some
Externí odkaz:
https://doaj.org/article/cfa356af1eb141edbe3ed4a952c6af57
Autor:
Jarosław Sławiński, Beata Żołnowska, Zdzisław Brzozowski, Anna Kawiak, Mariusz Belka, Tomasz Bączek
Publikováno v:
Molecules, Vol 20, Iss 4, Pp 5754-5770 (2015)
A series of new 6-chloro-3-(2-arylmethylene-1-methylhydrazino)-1,4,2-benzodithiazine 1,1-dioxide derivatives were effectively synthesized from N-methyl-N-(6-chloro-1,1-dioxo-1,4,2-benzodithiazin-3-yl)hydrazines. The intermediate compounds as well as
Externí odkaz:
https://doaj.org/article/58de604fa7484b7eb2293c6d839840c7
Autor:
Szymon Ulenberg, Mariusz Belka, Marek Król, Franciszek Herold, Weronika Hewelt-Belka, Agata Kot-Wasik, Tomasz Bączek
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0122772 (2015)
Other than efficacy of interaction with the molecular target, metabolic stability is the primary factor responsible for the failure or success of a compound in the drug development pipeline. The ideal drug candidate should be stable enough to reach i
Externí odkaz:
https://doaj.org/article/b56f0cc51fa740d08c71e9ed1a72c24a
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98096 (2014)
A set of 15 new sulphonamide derivatives, presenting antitumor activity have been subjected to a metabolic stability study. The results showed that besides products of biotransformation, some additional peaks occurred in chromatograms. Tandem mass sp
Externí odkaz:
https://doaj.org/article/61c2e6f0ed994638a9154d3ff0da5d66
Autor:
Beata Żołnowska, Jarosław Sławiński, Aneta Pogorzelska, Krzysztof Szafrański, Anna Kawiak, Grzegorz Stasiłojć, Mariusz Belka, Szymon Ulenberg, Tomasz Bączek, Jarosław Chojnacki
Publikováno v:
Molecules, Vol 21, Iss 6, p 808 (2016)
A series of novel 5-substituted 2-(arylmethylthio)-4-chloro-N-(5-aryl-1,2,4-triazin-3-yl) benzenesulfonamide derivatives 27–60 have been synthesized by the reaction of aminoguanidines with an appropriate phenylglyoxal hydrate in glacial acetic acid
Externí odkaz:
https://doaj.org/article/989ecdc9655f4b0c8337523c6838227c
Autor:
Kawiak, Beata Żołnowska, Jarosław Sławiński, Mariusz Belka, Tomasz Bączek, Jarosław Chojnacki, Anna
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 11; Pages: 9768
A series of novel 2-alkythio-4-chloro-N-[imino-(heteroaryl)methyl]benzenesulfonamide derivatives, 8–24, were synthesized in the reaction of the N-(benzenesulfonyl)cyanamide potassium salts 1–7 with the appropriate mercaptoheterocycles. All the sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::fe018555dc2543ca9907c1cda88442ef
Publikováno v:
Journal of Chromatography A. 1698:463981
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::963850126a019e5e054fd907b4025159
https://doi.org/10.1016/j.chroma.2023.463981
https://doi.org/10.1016/j.chroma.2023.463981
Publikováno v:
Acta Poloniae Pharmaceutica - Drug Research. 77:69-76
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6d7c13238613514e5945d183bea2d57
https://doi.org/10.32383/appdr/111813
https://doi.org/10.32383/appdr/111813