Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Mariusz Karbowski"'
Autor:
Maura Greiser, Mariusz Karbowski, Aaron David Kaplan, Andrew Kyle Coleman, Nicolas Verhoeven, Carmen A Mannella, W Jonathan Lederer, Liron Boyman
Publikováno v:
eLife, Vol 12 (2023)
Mitochondrial ATP production in ventricular cardiomyocytes must be continually adjusted to rapidly replenish the ATP consumed by the working heart. Two systems are known to be critical in this regulation: mitochondrial matrix Ca2+ ([Ca2+]m) and blood
Externí odkaz:
https://doaj.org/article/165b4639279f459893cd06a93cbac943
Autor:
Anna J. Dellomo, Rachel Abbotts, Christian L. Eberly, Mariusz Karbowski, Maria R. Baer, Tami J. Kingsbury, Feyruz V. Rassool
Publikováno v:
Translational Oncology, Vol 15, Iss 1, Pp 101283- (2022)
Signal transducer and activator of transcription 5 (STAT5) signaling plays a pathogenic role in both hematologic malignancies and solid tumors. In acute myeloid leukemia (AML), internal tandem duplications of fms-like tyrosine kinase 3 (FLT3-ITD) con
Externí odkaz:
https://doaj.org/article/1a37956d049b40a797eb0d03b6d03d1b
Autor:
Maura Greiser, Mariusz Karbowski, Aaron D. Kaplan, Andrew K. Coleman, Carmen A. Mannella, W. J. Lederer, Liron Boyman
Mitochondrial ATP production in cardiac ventricular myocytes must be continually adjusted to rapidly replenish the ATP consumed by the working heart. Two systems are known to be critical in this regulation: mitochondrial matrix Ca2+([Ca2+]m) and bloo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d016d5312f13fc3f9d2cba9d1bc8dec
https://doi.org/10.1101/2022.10.31.514581
https://doi.org/10.1101/2022.10.31.514581
Publikováno v:
Cellular and Molecular Life Sciences. 79
Through their role in energy generation and regulation of several vital pathways, including apoptosis and inflammation, mitochondria are critical for the life of eukaryotic organisms. Mitochondrial dysfunction is a major problem implicated in the eti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd344bf221eae40342f98ca46fa2e9f
https://doi.org/10.1007/s00018-022-04604-8
https://doi.org/10.1007/s00018-022-04604-8
Autor:
Mariusz Karbowski, Humberto C. Joca, Libet Garber, Liron Boyman, Christopher W. Ward, W. Jonathan Lederer, Maura Greiser
Publikováno v:
Biophysical Journal. 122:375a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbf8f44bc2e2c1e116908ba9d341e284
https://doi.org/10.1016/j.bpj.2022.11.2063
https://doi.org/10.1016/j.bpj.2022.11.2063
Autor:
Maura Greiser, Mariusz Karbowski, Aaron D. Kaplan, Andrew Coleman, Carmen A. Mannella, W. Jonathan Lederer, Liron Boyman
Publikováno v:
Biophysical Journal. 122:94a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5c5b2c58cc930e26b0863e7fc05dd90
https://doi.org/10.1016/j.bpj.2022.11.703
https://doi.org/10.1016/j.bpj.2022.11.703
Autor:
Christian Eberly, Feyruz V. Rassool, Tami J. Kingsbury, Rachel Abbotts, Maria R. Baer, Anna J. Dellomo, Mariusz Karbowski
Publikováno v:
Translational Oncology
Translational Oncology, Vol 15, Iss 1, Pp 101283-(2022)
Translational Oncology, Vol 15, Iss 1, Pp 101283-(2022)
Highlights • PARP1-dependent PARylation post-translationally modifies and regulates STAT5. • Catalytic PARP inhibition reduces STAT5 stability. • PARP1 loss results in reduced STAT5 signaling and activation of downstream targets. • STAT5-acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::916da008d282136e1f62a1519153d4fb
http://europepmc.org/articles/PMC8609071
http://europepmc.org/articles/PMC8609071
Publikováno v:
Autophagy
Among other mechanisms, mitochondrial membrane dynamics including mitochondrial fission and fusion, and the activity of the ubiquitin (Ub)-proteasome system (UPS) both are critical for maintaining mitochondrial function. To advance our knowledge of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10e6b918d4295a6855bc6a873b9c71b
https://pubmed.ncbi.nlm.nih.gov/34486484
https://pubmed.ncbi.nlm.nih.gov/34486484
Autor:
Brian M. Polster, Maureen A. Kane, Nicolas Verhoeven, Yumiko Oshima, W. Jonathan Lederer, Liron Boyman, Etienne Cartier, Weiliang Huang, Mariusz Karbowski
Publikováno v:
The Journal of Cell Biology
Oshima et al. report that in the absence of Parkin activity, cells adapt to mitochondrial proteotoxicity through a Drp1-mediated mechanism that includes the severing of the OMM and IMM ubiquitination, followed by recruitment of autophagy machinery to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2371c5e563b95dc02e0d37fcb6bee170
https://doi.org/10.1083/jcb.202006043
https://doi.org/10.1083/jcb.202006043
Autor:
Jessie E. Greenslade, Brian M. Polster, Miguel A. Prado, Daniel Finley, Mariusz Karbowski, Nicole R. Higgins, Trong H. Phung, Mervyn J. Monteiro, Brian C. Lin
Publikováno v:
Hum Mol Genet
UBQLN2 mutations cause amyotrophic lateral sclerosis (ALS) with frontotemporal dementia (FTD), but the pathogenic mechanisms by which they cause disease remain unclear. Proteomic profiling identified ‘mitochondrial proteins’ as comprising the lar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d595b464bd5d1ab291b83a81c08ef0
https://pubmed.ncbi.nlm.nih.gov/33891006
https://pubmed.ncbi.nlm.nih.gov/33891006