Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Marius Mickunas"'
Autor:
Jia-Yuan Zhang, Fiona Hamey, Dominik Trzupek, Marius Mickunas, Mercede Lee, Leila Godfrey, Jennie H. M. Yang, Marcin L. Pekalski, Jane Kennet, Frank Waldron-Lynch, Mark L. Evans, Timothy I. M. Tree, Linda S. Wicker, John A. Todd, Ricardo C. Ferreira
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Low-dose interleukin-2 is showing promise in the treatment of several autoimmune inflammatory diseases. Here authors map the trajectory of cellular and transcriptional changes in type 1 diabetes patients receiving an interval dosing interleukin-2 reg
Externí odkaz:
https://doaj.org/article/1cbfc186befb4c289f8694e2f8ebe72c
Autor:
Jennie H. M. Yang, Leena Khatri, Marius Mickunas, Evangelia Williams, Danijela Tatovic, Mohammad Alhadj Ali, Philippa Young, Penelope Moyle, Vishal Sahni, Ryan Wang, Rejbinder Kaur, Gillian M. Tannahill, Andrew R. Beaton, Danielle M. Gerlag, Caroline O. S. Savage, Antonella Napolitano Rosen, Frank Waldron-Lynch, Colin M. Dayan, Timothy I. M. Tree
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Background: Ultrasound guided sampling of human lymph node (LN) combined with advanced flow cytometry allows phenotypic analysis of multiple immune cell subsets. These may provide insights into immune processes and responses to immunotherapies not ap
Externí odkaz:
https://doaj.org/article/69d6c7577a7e4a29879bacbc563ce034
Autor:
Jia-Yuan Zhang, Fiona Hamey, Dominik Trzupek, Marius Mickunas, Mercede Lee, Leila Godfrey, Jennie H.M. Yang, Marcin L Pekalski, Jane Kennet, Frank Waldron-Lynch, Mark L. Evans, Timothy I. M. Tree, Linda S. Wicker, John A. Todd, Ricardo C. Ferreira
Despite early clinical successes, the mechanisms of action of low-dose interleukin-2 (LD-IL-2) immunotherapy remain only partly understood. Here, we examined the effects of interval administration of low-dose recombinant IL-2 (iLD-IL-2) using high-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58d12ca3a987c2d017f0c1f851a51879
https://doi.org/10.1101/2022.04.05.22273167
https://doi.org/10.1101/2022.04.05.22273167
Autor:
Paul R. Heath, Cecilia Garlanda, Andrea Malaspina, P. Nigel Leigh, William Camu, Henrik Zetterberg, Christophe Masseguin, Gilbert Bensimon, Ilaria Giovannelli, Jean-Luc Veyrune, Abigail Brown, Ulf Andreasson, Dennis Wang, Nadhim Bayatti, Pamela J. Shaw, Massimo Locati, Ammar Al-Chalabi, Christine Payan, Safa Saker, Janine Kirby, Nicolas Pageot, John De Vos, Carey M. Suehs, Marius Mickunas, Raul Juntas-Morales, Timothy Tree
Publikováno v:
Brain Communications
Brain Communications, Oxford University Press on behalf of the Guarantors of Brain, 2021, 3 (3), ⟨10.1093/braincomms/fcab141⟩
Brain Communications, Oxford University Press on behalf of the Guarantors of Brain, 2021, 3 (3), ⟨10.1093/braincomms/fcab141⟩
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease causing upper and lower motor neuron loss and currently no effective disease-modifying treatment is available. A pathological feature of this disease is neuroinflammation, a mechanism
Autor:
Raul Juntas-Morales, Marius Mickunas, Massimo Locati, Timothy Tree, Nicolas Pageot, John De Vos, Jean-Luc Veyrune, P. Nigel Leigh, William Camu, Ulf Andreasson, Christine Payan, Janine Kirby, Pamela J. Shaw, Ammar Al-Chalabi, Christophe Masseguin, Safa Saker, Carey M. Suehs, Cecilia Garlanda, Henrik Zetterberg, Andrea Malaspina, Gilbert Bensimon
Publikováno v:
EBioMedicine
EBioMedicine, Elsevier, 2020, 59, pp.102844. ⟨10.1016/j.ebiom.2020.102844⟩
EBioMedicine, 2020, 59, pp.102844. ⟨10.1016/j.ebiom.2020.102844⟩
EBioMedicine, Elsevier, 2020, 59, pp.102844. ⟨10.1016/j.ebiom.2020.102844⟩
EBioMedicine, 2020, 59, pp.102844. ⟨10.1016/j.ebiom.2020.102844⟩
Background\ud \ud Low-dose interleukin-2 (ld-IL-2) enhances regulatory T-cell (Treg) function in auto-inflammatory conditions. Neuroinflammation being a pathogenic feature of amyotrophic lateral sclerosis (ALS), we evaluated the pharmacodynamics and
Autor:
Ute-Christiane Meier, Sofia Sisay, Lorena Lopez-Lozano, Antonio Quiroga-Fernández, Roberto Alvarez Lafuente, Marius Mickunas, Jacqueline Palace, Gary Warnes, Priyamvada Dua
Publikováno v:
Journal of neuroimmunology. 306
Background Multiple sclerosis (MS) is an inflammatory and neurodegenerative disorder of the central nervous system (CNS). Reliable biomarkers are urgently needed for its diagnosis and management, and as clues to its pathogenesis, in which EBV is impl