Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Marius Löppenberg"'
Autor:
Ralph Holl, Oriana Agoglitta, Johannes Kirchmair, Marius Löppenberg, Fabian Galla, Magdalena Galster, Frederik Börgel
Publikováno v:
Tetrahedron
The Zn2+-dependent bacterial deacetylase LpxC is a promising target for the development of novel antibiotics. Most of the known LpxC inhibitors carry a hydroxamate moiety as Zn2+-binding group. However, hydroxamic acids generally exhibit poor pharmac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c367d6a57f9fc696c25f9467b92ad98
https://hdl.handle.net/1956/21532
https://hdl.handle.net/1956/21532
Publikováno v:
Tetrahedron. 71:956-966
Lipopolysaccharides (LPS) are the main component of the outer leaflet of the outer membrane of Gram-negative bacteria, serving as a permeability barrier, which protects the bacteria from many antibiotics. LpxC, a Zn2+-dependent enzyme, catalyzes the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99d1c6cb921cb79fde301fe2af686d47
https://doi.org/10.1016/j.tet.2014.12.069
https://doi.org/10.1016/j.tet.2014.12.069
Publikováno v:
Tetrahedron. 70:6569-6577
C-Triazolyl β-d-furanosides 10a–f were synthesized in a stereocontrolled way, starting from d-mannose. In the key steps of the synthesis a diastereoselective reduction of hemiketal 14 and a Cu(I) catalyzed [3+2]-cycloaddition of central building b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00491677de66ff6cd3b5eed34007edf3
https://doi.org/10.1016/j.tet.2014.07.016
https://doi.org/10.1016/j.tet.2014.07.016
Autor:
Marius Löppenberg, Wolfgang Sippl, Kanin Wichapong, Joachim Jose, Ralph Holl, Jelena Melesina, Marina Szermerski
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:1016-1028
The inhibition of the UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase (LpxC) represents a promising strategy to combat infections caused by multidrug-resistant Gram-negative bacteria. In order to elucidate the functional groups being
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ec9dabc4e30589b978c74080f99131
https://doi.org/10.1016/j.bmc.2013.12.057
https://doi.org/10.1016/j.bmc.2013.12.057
Publikováno v:
Tetrahedron. 69:9434-9442
The Zn2+-dependent deacetylase LpxC plays an important role in the biosynthesis of the cell wall of Gram-negative bacteria and therefore represents an interesting target for the development of novel antibiotics. In a 10-step, chiral pool synthesis st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96440d08d21e8163fead7e998d0f17bc
https://doi.org/10.1016/j.tet.2013.08.074
https://doi.org/10.1016/j.tet.2013.08.074
Autor:
Ralph Holl, Hannes Müller, Carla Pulina, Alberto Oddo, Mark G. Teese, Marius Löppenberg, Joachim Jose
Publikováno v:
Organicbiomolecular chemistry. 11(36)
Inhibitors of the UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase (LpxC) represent promising candidates for the development of antibiotics possessing a so far unexploited mechanism of action. In a chiral pool synthesis, starting from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0292d90ef1ab490822831a79acc729cb
https://pubmed.ncbi.nlm.nih.gov/23917427
https://pubmed.ncbi.nlm.nih.gov/23917427