Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Marius Kostelic"'
Charge detection mass spectrometry (CDMS) enables the direct mass measurement of heterogenous samples on the megadalton scale, as the charge state for a single ion is determined simultaneously with mass to charge ratio (m/z). Surface-induced dissocia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18fc12598385ef96e326b21169193b9d
https://doi.org/10.26434/chemrxiv-2023-hjr08
https://doi.org/10.26434/chemrxiv-2023-hjr08
Autor:
Henry Sanders, Farzaneh Chalyavi, Caitlyn Fields, Marius Kostelic, Ming-Hao Li, Daniel Raleigh, Martin Zanni, Michael Marty
The aggregation of islet amyloid polypeptide (IAPP) is associated with beta-cell dysfunction in type 2 diabetes (T2D) in humans. One possible mechanism of toxicity is the interaction of IAPP oligomers with lipid membranes to disrupt bilayer integrity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::892e681763e29b110f9d276728b18be2
https://doi.org/10.26434/chemrxiv-2023-cbs7n
https://doi.org/10.26434/chemrxiv-2023-cbs7n
Autor:
Marius Kostelic, Chih-Chieh Hsieh, Ciara Zak, Jack Ryan, Erin Baker, Craig Aspinwall, Michael Marty
Native mass spectrometry (MS) and charge detection-mass spectrometry (CD-MS) have become versatile tools for characterizing a wide range of proteins and macromolecular complexes. Both commonly use nano-electrospray ionization (nESI) from pulled boros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc5a7536cbd6440c5a5b845d2a8bb917
https://doi.org/10.26434/chemrxiv-2022-5jwkz
https://doi.org/10.26434/chemrxiv-2022-5jwkz
Lipid membranes have recently been implicated in protein misfolding and disease etiology, including for α-synuclein and Parkinson’s Disease. However, it is challenging to study the intersection of protein complex formation, membrane interactions,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c76c01510accb536e6573099edc3d84
https://doi.org/10.26434/chemrxiv-2022-1gcs5
https://doi.org/10.26434/chemrxiv-2022-1gcs5
Antimicrobial peptides (AMPs) are an important part of the innate immune system and demonstrate promising applications in the fight against antibiotic resistant infections due to their unique mechanism of targeting bacterial membranes. However, it is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d1f1a57ad9e9ab783b92c7aa34eff87
https://doi.org/10.26434/chemrxiv-2021-m6mjj
https://doi.org/10.26434/chemrxiv-2021-m6mjj
Native mass spectrometry (MS) with nanodiscs is a promising technique for characterizing membrane protein and peptide interactions in lipid bilayers. However, prior studies have used nanodiscs made of only one or two lipids, which lack the complexity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::425628bafaa2e037460c970415f6bce0
https://doi.org/10.26434/chemrxiv.13954415
https://doi.org/10.26434/chemrxiv.13954415
Autor:
Michael Marty, Marius Kostelic
Intact protein, top-down, and native mass spectrometry (MS) generally require the deconvolution of electrospray ionization (ESI) mass spectra to assign the mass of components from their charge state distribution. For small, well-resolved proteins, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de819d37f38a6a97e0ce33184bd1d081
https://doi.org/10.26434/chemrxiv.13417118
https://doi.org/10.26434/chemrxiv.13417118