GATA3 expression is decreased in psoriasis and during epidermal regeneration; induction by narrow-band UVB and IL-4.

Autor: Emoke Rácz, Dorota Kurek, Marius Kant, Ewout M Baerveldt, Edwin Florencia, Sabine Mourits, Dick de Ridder, Jon D Laman, Leslie van der Fits, Errol P Prens

Publikováno v: PLoS ONE, Vol 6, Iss 5, p e19806 (2011)

Psoriasis is characterized by hyperproliferation of keratinocytes and by infiltration of activated Th1 and Th17 cells in the (epi)dermis. By expression microarray, we previously found the GATA3 transcription factor significantly downregulated in lesi

Externí odkaz: https://doaj.org/article/29378433bed34f2687c5267b85d2c84f

Ustekinumab improves psoriasis-related gene expression in noninvolved psoriatic skin without inhibition of the antimicrobial response

Autor: Ewout M. Baerveldt, D. Kurek, J.W.J. van Kilsdonk, Arne S. IJpma, Jon D. Laman, Patrick A. M. Jansen, Errol P. Prens, Armanda J. Onderdijk, Edwin Florencia, Marius Kant, Jeroen Bastiaans, P.J. van der Spek

Publikováno v: British Journal of Dermatology. 168:990-998

BACKGROUND: Ustekinumab is a fully human anti-p40 monoclonal antibody which neutralizes interleukin (IL)-12 and IL-23, thereby interfering with T-helper (Th)1/Th17 pathways and keratinocyte activation, and is highly effective in the treatment of psor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4cc43f47a8e1fac1a45397c3c42087a4
https://doi.org/10.1111/bjd.12175

Narrowband ultraviolet B inhibits innate cytosolic double-stranded RNA receptors in psoriatic skin and keratinocytes

Autor: Marius Kant, Emöke Rácz, Edwin Florencia, Nicolaas G. J. Jaspers, Errol P. Prens, Denise T. D. de Ridder, L. van der Fits, Jon D. Laman

Publikováno v: British Journal of Dermatology. 164:838-847

Summary Background The mode of action of narrowband ultraviolet B (NB-UVB) therapy in clearing psoriasis is incompletely understood, and in vivo studies at the molecular level in patients undergoing NB-UVB therapy are limited. We previously demonstra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c782e1eabc757f0aa84cd51e51eae7d0
https://doi.org/10.1111/j.1365-2133.2010.10169.x

Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis

Autor: Louis Boon, Jane S. A. Voerman, Leslie van der Fits, Ferry Cornelissen, Anne-Marie Mus, Sabine Mourits, Marius Kant, Jon D. Laman, Erik Lubberts, Edwin Florencia, Errol P. Prens

Publikováno v: Journal of Immunology, 182, 5836-5845. American Association of Immunologists

Topical application of imiquimod (IMQ), a TLR7/8 ligand and potent immune activator, can induce and exacerbate psoriasis, a chronic inflammatory skin disorder. Recently, a crucial role was proposed for the IL-23/IL-17 axis in psoriasis. We hypothesiz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a59b4574a04df88214c1208155b651
https://doi.org/10.4049/jimmunol.0802999

Langerinneg conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice

Autor: Heike Weighardt, Boris Reizis, Errol P. Prens, Bernhard Holzmann, Stanislav Pantelyushin, Christian Wohn, Burkhard Becher, Cheolho Cheong, Stefan Haak, Björn E. Clausen, Sabina Onderwater, Julia L. Ober-Blöbaum, Sonja Zahner, Marius Kant

Publikováno v: Proc. Natl. Acad. Sci. U.S.A. 110, 10723-10728 (2013)
Proceedings of the National Academy of Sciences of the United States of America
Europe PubMed Central
Proceedings of the National Academy of Sciences of the U.S.A., 110(26), 10723-10728. National Academy of Sciences

Psoriasis is an autoinflammatory skin disease of unknown etiology. Topical application of Aldara cream containing the Toll-like receptor (TLR)7 agonist Imiquimod (IMQ) onto patients induces flares of psoriasis. Likewise, in mice IMQ triggers patholog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce5f15076c8f58c6f1d6a41b7b43b9d8
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=26262