Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Marius C. Hoener"'
Autor:
Jan Thomann, Karolina E. Kolaczynska, Oliver V. Stoeckmann, Deborah Rudin, Patrick Vizeli, Marius C. Hoener, Christopher R. Pryce, Franz X. Vollenweider, Matthias E. Liechti, Urs Duthaler
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
In vivo, psilocybin is rapidly dephosphorylated to psilocin which induces psychedelic effects by interacting with the 5-HT2A receptor. Psilocin primarily undergoes glucuronidation or conversion to 4-hydroxyindole-3-acetic acid (4-HIAA). Herein, we in
Externí odkaz:
https://doaj.org/article/4de9dedd97a84c36b079001eb96b0419
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
3,4,5-Trimethoxyphenethylamine (mescaline) is a psychedelic alkaloid found in peyote cactus. Related 4-alkoxy-3,5-dimethoxy-substituted phenethylamines (scalines) and amphetamines (3C-scalines) are reported to induce similarly potent psychedelic effe
Externí odkaz:
https://doaj.org/article/3e599d3cf5364048a1598b0c753ccd96
Autor:
Claudia Milazzo, Edwin J. Mientjes, Ilse Wallaard, Søren Vestergaard Rasmussen, Kamille Dumong Erichsen, Tejaswini Kakunuri, A.S. Elise van der Sman, Thomas Kremer, Meghan T. Miller, Marius C. Hoener, Ype Elgersma
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
Angelman syndrome (AS) is a severe neurodevelopmental disorder for which only symptomatic treatment with limited benefits is available. AS is caused by mutations affecting the maternally inherited ubiquitin protein ligase E3A (UBE3A) gene. Previous s
Externí odkaz:
https://doaj.org/article/4d87e9763e67445f825996968575d00d
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Background: 2,4,5-Trimethoxyamphetamine (TMA-2) is a potent psychedelic compound. Structurally related 4-alkyloxy-substituted 2,5-dimethoxyamphetamines and phenethylamine congeners (2C-O derivatives) have been described but their pharmacology is most
Externí odkaz:
https://doaj.org/article/965eba4a72d04f698a20b8ae9a20371b
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11576 (2021)
TAAR1 is a neuroregulator with emerging evidence suggesting a role in immunomodulation. Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system. Here, we investigate TAAR1 expression in human primary monocyte
Externí odkaz:
https://doaj.org/article/400c40f3545e4f048a4d3ac2d8e6195f
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8277 (2021)
Pyrovalerone cathinones are potent psychoactive substances that possess a pyrrolidine moiety. Pyrovalerone-type novel psychoactive substances (NPS) are continuously detected but their pharmacology and toxicology are largely unknown. We assessed sever
Externí odkaz:
https://doaj.org/article/2dcd838114b24936a4b25fbc4063e619
Autor:
Susanne Raab, Haiyan Wang, Sabine Uhles, Nadine Cole, Ruben Alvarez-Sanchez, Basil Künnecke, Christoph Ullmer, Hugues Matile, Marc Bedoucha, Roger D. Norcross, Nickki Ottaway-Parker, Diego Perez-Tilve, Karin Conde Knape, Matthias H. Tschöp, Marius C. Hoener, Sabine Sewing
Publikováno v:
Molecular Metabolism, Vol 5, Iss 1, Pp 47-56 (2016)
Objective: Type 2 diabetes and obesity are emerging pandemics in the 21st century creating worldwide urgency for the development of novel and safe therapies. We investigated trace amine-associated receptor 1 (TAAR1) as a novel target contributing to
Externí odkaz:
https://doaj.org/article/ad2d43af62f34cb681ec8b5659f0cd52
Autor:
Anja Harmeier, Claas A. Meyer, Andreas Staempfli, Fabio Casagrande, Marija M. Petrinovic, Yan-Ping Zhang, Basil Künnecke, Antonio Iglesias, Oliver P. Höner, Marius C. Hoener
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Individuals of many species rely on odors to communicate, find breeding partners, locate resources and sense dangers. In vertebrates, odorants are detected by chemosensory receptors of the olfactory system. One class of these receptors, the trace ami
Externí odkaz:
https://doaj.org/article/505beaa63f0949768bb83ccb46262d21
Autor:
Michael D. Schwartz, Jeremiah B. Palmerston, Diana L. Lee, Marius C. Hoener, Thomas S. Kilduff
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Trace amines (TAs), endogenous amino acid metabolites that are structurally similar to the biogenic amines, are endogenous ligands for trace amine-associated receptor 1 (TAAR1), a GPCR that modulates dopaminergic, serotonergic, and glutamatergic acti
Externí odkaz:
https://doaj.org/article/8a8a0908edad4bb8b16204fd76ad1b61
Autor:
Karolina E. Kolaczynska, Paula Ducret, Daniel Trachsel, Marius C. Hoener, Matthias E. Liechti, Dino Luethi
Publikováno v:
European Neuropsychopharmacology. 59:9-22
3,4-methylenedioxyamphetamine (MDA) is a psychoactive compound chemically related to the entactogen MDMA. MDA shares some of the entactogenic effects of MDMA but also exerts stimulant effects and psychedelic properties at higher doses. Here, we exami