Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Marius C, van den Heuvel"'
Autor:
Thomas A. Kluiver, Yuyan Lu, Stephanie A. Schubert, Lianne J. Kraaier, Femke Ringnalda, Philip Lijnzaad, Jeff DeMartino, Wouter L. Megchelenbrink, Vicky Amo-Addae, Selma Eising, Flavia W. de Faria, Daniel Münter, Marc van de Wetering, Kornelius Kerl, Evelien Duiker, Marius C. van den Heuvel, Vincent E. de Meijer, Ruben H. de Kleine, Jan J. Molenaar, Thanasis Margaritis, Hendrik G. Stunnenberg, Ronald R. de Krijger, József Zsiros, Hans Clevers, Weng Chuan Peng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Hepatoblastoma, the most prevalent pediatric liver cancer, almost always carries a WNT-activating CTNNB1 mutation, yet exhibits notable molecular heterogeneity. To characterize this heterogeneity and identify novel targeted therapies, we per
Externí odkaz:
https://doaj.org/article/e9c310a9ac5d476ba9c8f3c8d25d32c8
Autor:
Tobias M. Huijink, MD, Cor J. van ‘t Hof, BSc, L. Annick van Furth, BSc, Nora A. de Haan, BAS, Hanno Maassen, MD, Leonie H. Venema, PhD, Rosa G.M. Lammerts, MD, PhD, Marius C. van den Heuvel, MD, Jan-Luuk Hillebrands, PhD, Jacob van den Born, PhD, Stefan P. Berger, MD, PhD, Henri G.D. Leuvenink, PhD
Publikováno v:
Transplantation Direct, Vol 9, Iss 8, p e1507 (2023)
Background. Normothermic machine perfusion (NMP) is a promising modality for marginal donor kidneys. However, little is known about the effects of NMP on causing endothelial glycocalyx (eGC) injury. This study aims to evaluate the effects of NMP on e
Externí odkaz:
https://doaj.org/article/a61119e044b044dfaaa8e082a8b2f83c
Human precision-cut cystic duct and gallbladder slices: a novel method for studying cholangiopathies
Autor:
Jeske Fridrichs, Bart Hamel, Wendy Kelder, Ewoud van den Hoed, Marius C. van den Heuvel, Jan B. F. Hulscher, Peter Olinga
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
Background and aimsPrecision-cut tissue slices (PCTS) are widely used as an ex vivo culture tissue culture technique to study pathogeneses of diseases and drug activities in organs in vitro. A novel application of the PCTS model may be in the field o
Externí odkaz:
https://doaj.org/article/34ad282979d94046bbf1cd2d1f717ab6
Autor:
Tamar A. J. van den Berg, Marius C. van den Heuvel, Janneke Wiersema-Buist, Jelle Adelmeijer, Gertrude J. Nieuwenhuijs-Moeke, Ton Lisman, Stephan J. L. Bakker, Harry van Goor, TransplantLines Investigators, Robert A. Pol
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract In kidney transplantation, microthrombi and fibrin deposition may lead to local perfusion disorders and subsequently poor initial graft function. Microthrombi are often regarded as donor-derived. However, the incidence, time of development,
Externí odkaz:
https://doaj.org/article/4cce22d773de45a3b5f7036933a321cc
Autor:
Meint Volbeda, Daniela Jou-Valencia, Marius C. van den Heuvel, Marjolein Knoester, Peter J. Zwiers, Janesh Pillay, Stefan P. Berger, Peter H. J. van der Voort, Jan G. Zijlstra, Matijs van Meurs, Jill Moser
Publikováno v:
Critical Care, Vol 25, Iss 1, Pp 1-12 (2021)
Abstract Background The mechanisms driving acute kidney injury (AKI) in critically ill COVID-19 patients are unclear. We collected kidney biopsies from COVID-19 AKI patients within 30 min after death in order to examine the histopathology and perform
Externí odkaz:
https://doaj.org/article/35ae7b7010c54d14b1f449e34df479d8
Autor:
Nienke E. Vuurberg, Ilsalien Bakker, Anne Loes van den Boom, Robbert J. de Haas, Evelien W. Duiker, Marius C. van den Heuvel, Joost M. Klaase
Publikováno v:
Case Reports in Gastroenterology, Vol 14, Iss 3, Pp 695-701 (2020)
A patient with cystic fibrosis (CF) with pancreatic insufficiency presented with jaundice due to an ampullary tumour. CF is known for a higher incidence of gastrointestinal malignancies. The patient suffered from pancreatic insufficiency. At computed
Externí odkaz:
https://doaj.org/article/0e566f4e468a46feac023890d7f8b6a7
Autor:
Gesa Tiller, Rosa G. M. Lammerts, Jessy J. Karijosemito, Firas F. Alkaff, Arjan Diepstra, Robert A. Pol, Anita H. Meter-Arkema, Marc. A. Seelen, Marius C. van den Heuvel, Bouke G. Hepkema, Mohamed R. Daha, Jacob van den Born, Stefan P. Berger
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundThe role of the complement system in antibody-mediated rejection (ABMR) is insufficiently understood. We aimed to investigate the role of local and systemic complement activation in active (aABMR). We quantified complement activation marker
Externí odkaz:
https://doaj.org/article/0374bcdd6fcd4646a75af8dead091dd3
Autor:
Núria Lluís, Mario Serradilla-Martín, Mar Achalandabaso, François Jehaes, Bobby V.M. Dasari, Sara Mambrilla-Herrero, Ernesto Sparrelid, Anita Balakrishnan, Frederik J.H. Hoogwater, Maria J. Amaral, Bodil Andersson, Frederik Berrevoet, Alexandre Doussot, Víctor López-López, Mohammedsuror Alsammani, Olivier Detry, Carlos Domingo-del Pozo, Nikolaos Machairas, Damján Pekli, Cándido F. Alcázar-López, Horacio Asbun, Bergthor Björnsson, Thalis Christophides, Alberto Díez-Caballero, David Francart, Colin B. Noel, Donzília Sousa-Silva, Enrique Toledo-Martínez, George N. Tzimas, Sheraz Yaqub, François Cauchy, Mikel Prieto-Calvo, Melroy A. D’Souza, Harry V.M. Spiers, Marius C. van den Heuvel, Ramón Charco, Mickaël Lesurtel, José M. Ramia
Publikováno v:
International Journal of Surgery. 109:760-771
BACKGROUND/PURPOSE: Intraductal papillary neoplasm of the bile duct (IPNB) is a rare disease in Western countries. The main aim of this study was to characterize current surgical strategies and outcomes in the mainly European participating centers.ME
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099dc7226004f7c67a136389e5432974
https://doi.org/10.1097/js9.0000000000000280
https://doi.org/10.1097/js9.0000000000000280
Autor:
Merel B F Pool, Tim L Hamelink, Harry van Goor, Marius C van den Heuvel, Henri G D Leuvenink, Cyril Moers
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251595 (2021)
Normothermic machine perfusion (NMP) of donor kidneys provides the opportunity for improved graft preservation and objective pre-transplant ex-vivo organ assessment. Currently, a multitude of perfusion solutions exist for renal NMP. This study aimed
Externí odkaz:
https://doaj.org/article/e42573aac7ab4b489296dc1f21abb734
Autor:
Marloes Sol, Jan A. A. M. Kamps, Jacob van den Born, Marius C. van den Heuvel, Johan van der Vlag, Guido Krenning, Jan-Luuk Hillebrands
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Glomerular endothelial cell (GEnC) dysfunction is important in the pathogenesis of glomerular sclerotic diseases, including Focal Segmental Glomerulosclerosis (FSGS) and overt diabetic nephropathy (DN). GEnCs form the first cellular barrier in direct
Externí odkaz:
https://doaj.org/article/3961ebeb2c414abca1447b7eed969083