Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Marius, Wernig"'
Autor:
Gernot Neumayer, Jessica L. Torkelson, Shengdi Li, Kelly McCarthy, Hanson H. Zhen, Madhuri Vangipuram, Marius M. Mader, Gulilat Gebeyehu, Taysir M. Jaouni, Joanna Jacków-Malinowska, Avina Rami, Corey Hansen, Zongyou Guo, Sadhana Gaddam, Keri M. Tate, Alberto Pappalardo, Lingjie Li, Grace M. Chow, Kevin R. Roy, Thuylinh Michelle Nguyen, Koji Tanabe, Patrick S. McGrath, Amber Cramer, Anna Bruckner, Ganna Bilousova, Dennis Roop, Jean Y. Tang, Angela Christiano, Lars M. Steinmetz, Marius Wernig, Anthony E. Oro
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract We present Dystrophic Epidermolysis Bullosa Cell Therapy (DEBCT), a scalable platform producing autologous organotypic iPS cell-derived induced skin composite (iSC) grafts for definitive treatment. Clinical-grade manufacturing integrates CRI
Externí odkaz:
https://doaj.org/article/beaa5273b9ae4861a2bf161a05a28b1a
Autor:
Gintautas Vainorius, Maria Novatchkova, Georg Michlits, Juliane Christina Baar, Cecilia Raupach, Joonsun Lee, Ramesh Yelagandula, Marius Wernig, Ulrich Elling
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Ascl1 and Ngn2, closely related proneural transcription factors, are able to convert mouse embryonic stem cells into induced neurons. Despite their similarities, these factors elicit only partially overlapping transcriptional programs, and i
Externí odkaz:
https://doaj.org/article/be3b505e9315435b88d215c8c6ad0e64
Autor:
Bahareh Haddad Derafshi, Tamas Danko, Soham Chanda, Pedro J. Batista, Ulrike Litzenburger, Qian Yi Lee, Yi Han Ng, Anu Sebin, Howard Y. Chang, Thomas C. Südhof, Marius Wernig
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-28 (2022)
Abstract The chromodomain helicase DNA-binding protein CHD8 is the most frequently mutated gene in autism spectrum disorder. Despite its prominent disease involvement, little is known about its molecular function in the human brain. CHD8 is a chromat
Externí odkaz:
https://doaj.org/article/f6144c8eb12747dd9d2726213f094bb0
Publikováno v:
Cold Spring Harbor perspectives in biology. 14(10)
Embryonic development and cell specification have been viewed as an epigenetically rigid process. Through accumulation of irreversible epigenetic marks, the differentiation process has been considered unidirectional, and once completed cell specifica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ca857fc5f4ff5d4ba446e7280385cb
https://pubmed.ncbi.nlm.nih.gov/34872969
https://pubmed.ncbi.nlm.nih.gov/34872969
Autor:
Markus Wöhr, Wendy M. Fong, Justyna A. Janas, Moritz Mall, Christian Thome, Madhuri Vangipuram, Lingjun Meng, Thomas C. Südhof, Marius Wernig
Publikováno v:
Molecular Autism, Vol 13, Iss 1, Pp 1-28 (2022)
Abstract Background The zinc finger domain containing transcription factor Myt1l is tightly associated with neuronal identity and is the only transcription factor known that is both neuron-specific and expressed in all neuronal subtypes. We identifie
Externí odkaz:
https://doaj.org/article/b7ff67c9372c446f969eb6ed5f640478
Autor:
Nisha Raj, Zachary T. McEachin, William Harousseau, Ying Zhou, Feiran Zhang, Megan E. Merritt-Garza, J. Matthew Taliaferro, Magdalena Kalinowska, Samuele G. Marro, Chadwick M. Hales, Elizabeth Berry-Kravis, Marisol W. Wolf-Ochoa, Veronica Martinez-Cerdeño, Marius Wernig, Lu Chen, Eric Klann, Stephen T. Warren, Peng Jin, Zhexing Wen, Gary J. Bassell
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108991- (2021)
Summary: Transcriptional silencing of the FMR1 gene in fragile X syndrome (FXS) leads to the loss of the RNA-binding protein FMRP. In addition to regulating mRNA translation and protein synthesis, emerging evidence suggests that FMRP acts to coordina
Externí odkaz:
https://doaj.org/article/76c647a47e0f490d9394ecbde774aa77
Autor:
Orly L. Wapinski, Qian Yi Lee, Albert C. Chen, Rui Li, M. Ryan Corces, Cheen Euong Ang, Barbara Treutlein, Chaomei Xiang, Valérie Baubet, Fabian Patrik Suchy, Venkat Sankar, Sopheak Sim, Stephen R. Quake, Nadia Dahmane, Marius Wernig, Howard Y. Chang
Publikováno v:
Cell Reports, Vol 20, Iss 13, Pp 3236-3247 (2017)
How transcription factors (TFs) reprogram one cell lineage to another remains unclear. Here, we define chromatin accessibility changes induced by the proneural TF Ascl1 throughout conversion of fibroblasts into induced neuronal (iN) cells. Thousands
Externí odkaz:
https://doaj.org/article/f94ed8fb92644ec5875519ed63f8a4eb
Autor:
Nathaniel W. Mabe, Min Huang, Guillermo N. Dalton, Gabriela Alexe, Daniel A. Schaefer, Anna C. Geraghty, Amanda L. Robichaud, Amy S. Conway, Delan Khalid, Marius M. Mader, Julia A. Belk, Kenneth N. Ross, Michal Sheffer, Miles H. Linde, Nghi Ly, Winnie Yao, Maria Caterina Rotiroti, Benjamin A. H. Smith, Marius Wernig, Carolyn R. Bertozzi, Michelle Monje, Constantine S. Mitsiades, Ravindra Majeti, Ansuman T. Satpathy, Kimberly Stegmaier, Robbie G. Majzner
Publikováno v:
Nature Cancer. 3:976-993
Immunotherapy with anti-GD2 antibodies has advanced the treatment of children with high-risk neuroblastoma, but nearly half of patients relapse, and little is known about mechanisms of resistance to anti-GD2 therapy. Here, we show that reduced GD2 ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c9eabc77d406c8f3cf09781745ec5a
https://doi.org/10.1038/s43018-022-00405-x
https://doi.org/10.1038/s43018-022-00405-x
Publikováno v:
Neurobiology of Disease, Vol 130, Iss , Pp 104503- (2019)
One in three people will develop Alzheimer’s disease (AD) or another dementia and, despite intense research efforts, treatment options remain inadequate. Understanding the mechanisms of AD pathogenesis remains our principal hurdle to developing eff
Externí odkaz:
https://doaj.org/article/9f97758ed94d46c58bace49776008618
Autor:
Cheen Euong Ang, Qing Ma, Orly L Wapinski, ShengHua Fan, Ryan A Flynn, Qian Yi Lee, Bradley Coe, Masahiro Onoguchi, Victor Hipolito Olmos, Brian T Do, Lynn Dukes-Rimsky, Jin Xu, Koji Tanabe, LiangJiang Wang, Ulrich Elling, Josef M Penninger, Yang Zhao, Kun Qu, Evan E Eichler, Anand Srivastava, Marius Wernig, Howard Y Chang
Publikováno v:
eLife, Vol 8 (2019)
Long noncoding RNAs (lncRNAs) have been shown to act as important cell biological regulators including cell fate decisions but are often ignored in human genetics. Combining differential lncRNA expression during neuronal lineage induction with copy n
Externí odkaz:
https://doaj.org/article/60e20b5e18eb47a88838b2322084fb91