Cholesterol Embolization Syndrome After Kidney Transplantation: A Case Series and Systematic Review

Autor: Marith I. Francke, BSc, Marian C. Clahsen-van Groningen, MD, PhD, Thierry P. P. van den Bosch, PhD, Jan U. Becker, MD, PhD, Dennis A. Hesselink, MD, PhD

Publikováno v: Transplantation Direct, Vol 7, Iss 7, p e717 (2021)

Background. Cholesterol embolization syndrome (CES) is an uncommon but well-known cause of renal failure in native kidneys, but little is known about CES in kidney transplant recipients. The aim of this study was to determine the incidence, clinical

Externí odkaz: https://doaj.org/article/5ae0cc1c09cb4cd2aaddd133876cda02

Association Between the Intracellular Tacrolimus Concentration in CD3+ T Lymphocytes and CD14+ Monocytes and Acute Kidney Transplant Rejection

Autor: Suwasin Udomkarnjananun, Marith I. Francke, Marjolein Dieterich, Daan van de Velde, Jeroen G. H. P. Verhoeven, Karin Boer, Marian C. Clahsen-Van Groningen, Brenda C. M. De Winter, Carla C. Baan, Dennis A. Hesselink

Publikováno v: Therapeutic Drug Monitoring, 44(5), 625-632. Lippincott Williams & Wilkins

Background:Intracellular tacrolimus concentration in peripheral blood mononuclear cells (PBMCs) (TAC [PBMC]) has been proposed to better represent its active concentration than its whole blood concentration. As tacrolimus acts on T lymphocytes and ot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ad8249311065b06bf9a37354a8d83e0
https://pure.eur.nl/en/publications/94bf1fad-3bf4-4a46-9083-e6b7cd5726cf

The use of freeze-dried blood samples affects the results of a dried blood spot analysis

Autor: Marith I. Francke, Bart van Domburg, Daan van de Velde, Dennis A. Hesselink, Brenda C.M. de Winter

Publikováno v: Clinical Biochemistry, 104, 70-73. Elsevier Inc.

Dried blood spot (DBS) microsampling has several advantages over venous blood sampling. In a clinical validation study of tacrolimus microsampling it was noted that tacrolimus DBS concentrations ([Tac]DBS) were systematically higher than tacrolimus w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8279bd8ede4430bd84f139f04891035c
https://doi.org/10.1016/j.clinbiochem.2022.03.007

Best Practices to Implement Dried Blood Spot Sampling for Therapeutic Drug Monitoring in Clinical Practice

Autor: Marith I. Francke, Laura E. J. Peeters, Dennis A. Hesselink, Sanne M. Kloosterboer, Birgit C. P. Koch, Herman Veenhof, Brenda C. M. de Winter

Publikováno v: Therapeutic Drug Monitoring, 44(5), 696-700. LIPPINCOTT WILLIAMS & WILKINS
Therapeutic Drug Monitoring, 44(5), 696-700. Lippincott Williams & Wilkins

BACKGROUND: Sampling of blood at home to determine the concentration of drugs or other compounds can be effective in limiting hospital-based sampling. This could lower hospital visits and patient burden, improve the quality of life, and reduce health

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4b5f4b2672cd75a3157268eabe7a5e
https://research.rug.nl/en/publications/daa2af3a-2498-4ee7-bf91-23acfcc991c3

Avoiding Tacrolimus Underexposure and Overexposure with a Dosing Algorithm for Renal Transplant Recipients: A Single Arm Prospective Intervention Trial

Autor: Dennis A. Hesselink, Louise M. Andrews, Marian C. Clahsen-van Groningen, Brenda C. M. de Winter, Teun van Gelder, Jacqueline van de Wetering, Bronno van der Holt, Ron H.N. van Schaik, Marith I. Francke, Hoang Lan Le

Publikováno v: Clinical Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics, 110(1), 169-178. Wiley-Blackwell
Clinical Pharmacology and Therapeutics, 110(1), 169-178. WILEY

Bodyweight-based tacrolimus dosing followed by therapeutic drug monitoring is standard clinical care after renal transplantation. However, after transplantation, a meager 38% of patients are on target at first steady-state and it can take up to 3 wee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4da3e4d079809c47d6968b7f8d8e8c5
https://doi.org/10.1002/cpt.2163