Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Marita Overhoff"'
Autor:
Marita Overhoff
Publikováno v:
Chemie in unserer Zeit. 41:436-439
Die in den letzten Jahren entdeckten kleinen nicht kodierenden RNAs, wie siRNAs, miRNAs und rasiRNAs, regulieren auf unterschiedliche Art und Weise zellulare Ereignisse, wie z.B. die Differenzierung einer Zelle. Obwohl sie an sehr vielen Prozessen be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f283a89fd73187e1f3d1929783a309ab
https://doi.org/10.1002/ciuz.200700400
https://doi.org/10.1002/ciuz.200700400
Autor:
Miriam Mende, Anke Detzer, Marita Overhoff, Anne Hopert, Georg Sczakiel, Holger Kirchner, Kirsten Börngen, Peter Schlenke, Winfried Wünsche
Publikováno v:
Immunology. 120:261-272
Summary The relationship between immunostimulation of human B cells by cytosine–phosphate–guanosine (CpG) -containing oligonucleotides and their physical cellular uptake is of mechanistic interest and a prerequisite for rational improvements of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce238920a4abfb45eb927ba21d9c1ab
https://doi.org/10.1111/j.1365-2567.2006.02497.x
https://doi.org/10.1111/j.1365-2567.2006.02497.x
Autor:
Marc Lemaitre, Ian Robbins, Marita Overhoff, Georg Sczakiel, Rosel Kretschmer-Kazemi Far, Bernard Lebleu, Martina Alken
Publikováno v:
Journal of Molecular Biology. 348:871-881
The efficiency with which small interfering RNAs (siRNAs) down-regulate specific gene expression in living cells is variable and a number of sequence-governed, biochemical parameters of the siRNA duplex have been proposed for the design of an efficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968e257f661ca3bf49c8ff8e71a6f316
https://doi.org/10.1016/j.jmb.2005.03.012
https://doi.org/10.1016/j.jmb.2005.03.012
Increased RNAi is related to intracellular release of siRNA via a covalently attached signal peptide
Autor:
Michael J. Gait, Georg Sczakiel, Gabriela D. Ivanova, John J. Turner, Winfried Wünsche, Marita Overhoff, Maria Rompf, Anke Detzer
Publikováno v:
RNA (New York, N.Y.). 15(4)
In the last decade short interfering RNA (siRNA) became an important means for functional genomics and the development of gene-specific drugs. However, major technical hurdles in the application of siRNA include its cellular delivery followed by its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa9f9196707917cbb78f1952c6b8e15
https://pubmed.ncbi.nlm.nih.gov/19228587
https://pubmed.ncbi.nlm.nih.gov/19228587
Autor:
Marita Overhoff, Georg Sczakiel, Maria Wecke, Winfried Wünsche, Anke Detzer, Alessandra Mescalchin
Publikováno v:
Expert opinion on biological therapy. 7(10)
The cellular uptake of oligomeric nucleic acid-based tools and drugs including small-interfering RNA (siRNA) represents a major technical hurdle for the biologic effectiveness and therapeutic success in vivo. Subsequent to cellular delivery it is cru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea2a63b0d8cccf0492be3359d4e8a2e1
https://pubmed.ncbi.nlm.nih.gov/17916045
https://pubmed.ncbi.nlm.nih.gov/17916045
Autor:
Anke Detzer, Mike Gait, John J. Turner, Winfried Wünsche, Georg Sczakiel, Marita Overhoff, Maria Wecke
Publikováno v:
GBM Fall meeting Hamburg 2007. 2007
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd64840e1a2693de8ac5e4389497906c
https://doi.org/10.1240/sav_gbm_2007_h_001967
https://doi.org/10.1240/sav_gbm_2007_h_001967
Autor:
Marita Overhoff, Georg Sczakiel
Publikováno v:
EMBO reports. 6(12)
The cellular delivery of short interfering RNA (siRNA) is a main hurdle in therapeutic drug development. Here, we describe that phosphorothioate (PTO)-derived oligonucleotides stimulate the physical cellular uptake of siRNA in trans in human cells. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc12f0e80c342640987a86ca76c2df9
https://pubmed.ncbi.nlm.nih.gov/16170302
https://pubmed.ncbi.nlm.nih.gov/16170302
The quantitative detection of oligomeric nucleic acids including short double-stranded RNA in cells and tissues becomes increasingly important. Here, we describe a method for the detection of siRNA in extracts prepared from mammalian cells, which is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec4f9e92e5e8a6fc9ebe05f7dbdef0c9
https://europepmc.org/articles/PMC535697/
https://europepmc.org/articles/PMC535697/
