Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Marita Högberg"'
Autor:
Marita Högberg, Linda Rickardson, Marko J. Kallio, Emma Kutvonen, Stefan Rehnmark, Satu Orasniemi
Publikováno v:
Drug Design, Development and Therapy
Linda Rickardson,1 Emma Kutvonen,2 Satu Orasniemi,2 Marita Högberg,1 Marko J Kallio,2,3 Stefan Rehnmark1 1Noviga Research AB, Södertälje, Sweden; 2Department of Physiology, Institute of Biomedicine, University of Turku, 3Centre for Biotechnology,
Autor:
Iain Morrison, Marita Högberg
Publikováno v:
Expert Opinion on Therapeutic Patents. 10:1189-1199
Two classes of anti-HIV drugs are currently marketed which target the HIV-1 reverse transcriptase (RT). The first explored class was the nucleoside RT inhibitors (NRTIs), such as AZT, ddI, ddC, 3TC, D4T and abacavir, whereas the more recently launche
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:265-268
Bioisosteric substitution of the thiourea ( 3, 5, 7, 9 Download : Download high-res image (26KB) Download : Download full-size image Scheme 3 . ) and urea (10) moiety of PETT compounds with sulfamide ( 1 Download : Download high-res image (32KB) Down
Autor:
Mark A. Muesing, Robert Theodore Vasileff, Sahlberg C, Robert J. Ternansky, Cantrell As, C. L. Jordan, Jaskunas, L. Vrang, P. Engelhardt, Peter Thomas Lind, H. Zhang, Kinnick, R. Noreen, West Sj, Marita Högberg, Pranc P, J. Kangasmetsa, B. Oberg, N. G. Johansson, J. M. Jun. Morin
Publikováno v:
Journal of Medicinal Chemistry. 39:4261-4274
Phenylethylthiazolylthiourea (PETT) derivatives have been identified as a new series of non-nucleoside inhibitors of HIV-1 RT. Structure-activity relationship studies of this class of compounds resulted in the identification of N-[2-(2-pyridyl)ethyl]
Autor:
Johansson Nils Gunnar, F W Bell, Marita Högberg, Rolf Noreen, Jaskunas, C. L. Jordan, Cantrell As, Peter Thomas Lind, J. M. Jun. Morin, Kinnick
Publikováno v:
Journal of Medicinal Chemistry. 38:4929-4936
A novel series of potent specific HIV-1 inhibitory compounds is described. The lead compound in the series, N-(2-phenethyl)-N'-(2-thiazolyl)thiourea (1), inhibits HIV-1 RT using rCdG as the template with an IC50 of 0.9 microM. In MT-4 cells, compound
Autor:
Veli-Matti Mukkala, Marita Högberg, Marek Kwiatkowski, Jouko Kankare, Harri Takalo, Christian Sund, Paavo Pasanen
Publikováno v:
Helvetica Chimica Acta. 75:1621-1632
Twelve heteroaromatic complexing agents 9a–I were synthesized with the purpose to develop suitable labels for time-resolved luminescence-based bioaffinity assays. The relative luminescence yields, excitation maxima, and emission decay constants of
Autor:
Weimin Tong, Samir Abdurahman, Anders Vahlne, Ákos Végvári, Marita Högberg, Ivan Romero, Jan Balzarini, Stefan Höglund, Michael Levi
Publikováno v:
Retrovirology
Retrovirology; 6(34) (2009)
Retrovirology, Vol 6, Iss 1, p 34 (2009)
Retrovirology; 6(34) (2009)
Retrovirology, Vol 6, Iss 1, p 34 (2009)
Background Formation of an HIV-1 particle with a conical core structure is a prerequisite for the subsequent infectivity of the virus particle. We have previously described that glycineamide (G-NH2) when added to the culture medium of infected cells
Autor:
Samir Abdurahman, Anders Vahlne, Akos Vegvaris, Michael Levi, Alenca Jejcic, Peter Horal, Marita Högberg, Jan Balzarini, Elin Andersson, Stefan Höglund, Bo Svennerholm
Publikováno v:
Retrovirology. 2
Background We have previously shown that the tripeptide glycyl-prolyl-glycine-amide (GPG-amide) inhibits HIV-1 replication in vitro by affecting proper capsid assembly of HIV-1. However, GPG-amide failed in a phase II clinical trial on HIV-infected i
Autor:
Tommy Johansson, Ivan Romero, Emma Dahlstedt, Mikael Gillner, Linda Rickardson, Marita Högberg, Olof Smitt
Publikováno v:
Molecular Cancer Therapeutics. 12:A298-A298
Purpose: Microtubule targeting agents, represented by vinca alkaloids and taxanes, are extensively used in the clinic with good effects. However, these large molecules can only be administered by intravenous injections to the patient and they are als
Autor:
Bo Öberg, Peter Thomas Lind, N.-G. Johansson, Christer Sahlberg, Lotta Vrang, C. Lopez, J. Kangasmetä, Björn Classon, Marita Högberg, J. Munroe, Rolf Noreen, Hong Zhang, S. Mauldin, Robert J. Ternansky, J. M. Jun. Morin, P. Engelhardt
Publikováno v:
Antiviral Research. 26:A257