Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Marita Chakhtoura"'
Autor:
Massimiliano Bissa, Sohyoung Kim, Veronica Galli, Slim Fourati, Sarkis Sarkis, Anush Arakelyan, Isabela Silva de Castro, Mohammad Arif Rahman, Saori Fujiwara, Monica Vaccari, Jeffrey A. Tomalka, James D. Stamos, Luca Schifanella, Giacomo Gorini, Ramona Moles, Anna Gutowska, Guido Ferrari, Alexei Lobanov, David C. Montefiori, George W. Nelson, Margaret C. Cam, Marita Chakhtoura, Elias K. Haddad, Melvin N. Doster, Katherine McKinnon, Sophia Brown, David J. Venzon, Hyoyoung Choo-Wosoba, Matthew W. Breed, Kristin E. Killoran, Joshua Kramer, Leonid Margolis, Rafick P. Sekaly, Gordon L. Hager, Genoveffa Franchini
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
HIV vaccine development can be aided by knowledge of correlates of protection. Here the authors identify engagement and reprogramming of tolerogenic CD14+ myeloid cells mediating a spatiotemporal balance of pro- and anti-inflammatory responses, as co
Externí odkaz:
https://doaj.org/article/f273918f9336463f8dcd9cedb0b73046
Autor:
Margaret H. O’Connor, Roshell Muir, Marita Chakhtoura, Michael Fang, Eirini Moysi, Susan Moir, Alison J. Carey, Alyssa Terk, Carmen N. Nichols, Talibah Metcalf, Constantinos Petrovas, Mark J. Cameron, Virginie Tardif, Elias K. Haddad
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Margaret O’Connor et al. report a new Innate Lymphoid Cell population in human tonsils and lymph nodes that inhibit the functional interaction of follicular helper T cells and germinal center B cells. They show that this cell population is expanded
Externí odkaz:
https://doaj.org/article/a866230b1fdc4b2fb508ecc62a24397c
Autor:
Marita Chakhtoura, Mike Fang, Rafael Cubas, Margaret H O'Connor, Carmen N Nichols, Brian Richardson, Aarthi Talla, Susan Moir, Mark J Cameron, Virginie Tardif, Elias K Haddad
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009732 (2021)
We have recently demonstrated that the function of T follicular helper (Tfh) cells from lymph nodes (LN) of HIV-infected individuals is impaired. We found that these cells were unable to provide proper help to germinal center (GC)-B cells, as observe
Externí odkaz:
https://doaj.org/article/291573c3b8f04ece8dfdb7a54f6e1523
Autor:
Virginie Tardif, Roshell Muir, Rafael Cubas, Marita Chakhtoura, Peter Wilkinson, Talibah Metcalf, Rana Herro, Elias K. Haddad
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Follicular helper T cells are critical in the generation of the antibody response. Here the authors show that adenosine deaminase is involved in the Tfh program and ensuring the provision of B cell help.
Externí odkaz:
https://doaj.org/article/628425c3aec1481fb1851b02fede3b99
Autor:
Jinu Abraham, Sara Botto, Nobuyo Mizuno, Kara Pryke, Bryan Gall, Dylan Boehm, Tina M. Sali, Haihong Jin, Aaron Nilsen, Michael Gough, Jason Baird, Marita Chakhtoura, Caroline Subra, Lydie Trautmann, Elias K. Haddad, Victor R. DeFilippis
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The innate immune response to cytosolic DNA involves transcriptional activation of type I interferons (IFN-I) and proinflammatory cytokines. This represents the culmination of intracellular signaling pathways that are initiated by pattern recognition
Externí odkaz:
https://doaj.org/article/31d8bd92b5c644bc9bd8223516f664ff
Autor:
Marita Chakhtoura, Robert W. Chain, Priscila Y. Sato, Connie C. Qiu, Michael H. Lee, Joseph J. Meissler, Toby K. Eisenstein, Walter J. Koch, Roberto Caricchio, Stefania Gallucci
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Attenuating the innate immunity activation could ameliorate inflammation and disease in settings such as transplant rejection or autoimmunity. Recently, a pivotal role for metabolic re-programming in TLR-induced dendritic cell (DC) activation has eme
Externí odkaz:
https://doaj.org/article/1b1c991004284f68a051fbce56f145af
Autor:
Mohamad A Bitar, Charbel Rameh, Nour F Ataya, Alik Najarian, Marita Chakhtoura, Alexander Abdelnoor
Publikováno v:
Journal of Pediatrics Review, Vol 4, Iss 2, Pp 19-30 (2016)
Background: The palatine tonsils are secondary lymphoid organs, important in sampling antigens directly from the epithelial surfaces. They produce antibodies locally and distally through their migrating B cells. Objectives: The aim of this study w
Externí odkaz:
https://doaj.org/article/141101f275aa44cd8c44da934b1514d2
Publikováno v:
Journal of Immunology Research, Vol 2018 (2018)
Type I interferons (IFN) are pathogenic in systemic lupus erythematosus (SLE) and were proposed to control the immunometabolism of dendritic cells (DCs). We previously reported that DCs from female lupus-prone mice constitutively overexpress IFN-resp
Externí odkaz:
https://doaj.org/article/b8c3904f5bd74243b490b9b361f3a2c9
Autor:
Kara M. Pryke, Jinu Abraham, Tina M. Sali, Bryan J. Gall, Iris Archer, Andrew Liu, Shelly Bambina, Jason Baird, Michael Gough, Marita Chakhtoura, Elias K. Haddad, Ilsa T. Kirby, Aaron Nilsen, Daniel N. Streblow, Alec J. Hirsch, Jessica L. Smith, Victor R. DeFilippis
Publikováno v:
mBio, Vol 8, Iss 3 (2017)
ABSTRACT The ongoing concurrent outbreaks of Zika, Chikungunya, and dengue viruses in Latin America and the Caribbean highlight the need for development of broad-spectrum antiviral treatments. The type I interferon (IFN) system has evolved in vertebr
Externí odkaz:
https://doaj.org/article/09f2dc17e4774d63a4c91dc285882276
Autor:
Marita Chakhtoura, Uma Sriram, Michelle Heayn, Joshua Wonsidler, Christopher Doyle, Joudy-Ann Dinnall, Stefania Gallucci, Rebecca A. Roberts
Publikováno v:
Mediators of Inflammation, Vol 2017 (2017)
Sex hormones affect immune responses and might promote autoimmunity. Endocrine disrupting chemicals such as bisphenol A (BPA) may mimic their immune effects. Conventional dendritic cells (cDCs) are pivotal initiators of immune responses upon activati
Externí odkaz:
https://doaj.org/article/f49cf92498754be8a6da1ab4604a4c1f