Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Marit W. Vermunt"'
Autor:
Haoyue Zhang, Jessica Lam, Di Zhang, Yemin Lan, Marit W. Vermunt, Cheryl A. Keller, Belinda Giardine, Ross C. Hardison, Gerd A. Blobel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Higher-order chromatin structure is temporarily disrupted during mitosis. Here the authors show that loss of the architectural factor CTCF results in failure to form structural loops and leads to inappropriate cis-regulatory contacts and alterations
Externí odkaz:
https://doaj.org/article/08ba3d74d9e640238388f116decac99f
Autor:
Bas Castelijns, Mirna L. Baak, Ilia S. Timpanaro, Caroline R. M. Wiggers, Marit W. Vermunt, Peng Shang, Ivanela Kondova, Geert Geeven, Valerio Bianchi, Wouter de Laat, Niels Geijsen, Menno P. Creyghton
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
The understanding of the changes regulating gene expression relevant for the emergence of the human brain and its susceptibility to disease is limited. Here, the authors identified a set of regulatory elements that evolved in hominins affecting oligo
Externí odkaz:
https://doaj.org/article/82266434e4204259b6a7fa449dc212bd
Autor:
Jing Luan, Guanjue Xiang, Pablo Aurelio Gómez-García, Jacob M. Tome, Zhe Zhang, Marit W. Vermunt, Haoyue Zhang, Anran Huang, Cheryl A. Keller, Belinda M. Giardine, Yu Zhang, Yemin Lan, John T. Lis, Melike Lakadamyali, Ross C. Hardison, Gerd A. Blobel
Publikováno v:
Cell Reports, Vol 34, Iss 8, Pp 108783- (2021)
Summary: CCCTC-binding factor (CTCF) is a conserved zinc finger transcription factor implicated in a wide range of functions, including genome organization, transcription activation, and elongation. To explore the basis for CTCF functional diversity,
Externí odkaz:
https://doaj.org/article/043972196e1e41779878b3c99b1de8c7
Autor:
Marit W. Vermunt, Peter Reinink, Jeroen Korving, Ewart de Bruijn, Paul M. Creyghton, Onur Basak, Geert Geeven, Pim W. Toonen, Nico Lansu, Charles Meunier, Sebastiaan van Heesch, Hans Clevers, Wouter de Laat, Edwin Cuppen, Menno P. Creyghton
Publikováno v:
Cell Reports, Vol 9, Iss 2, Pp 767-779 (2014)
Understanding the complexity of the human brain and its functional diversity remain a major challenge. Distinct anatomical regions are involved in an array of processes, including organismal homeostasis, cognitive functions, and susceptibility to neu
Externí odkaz:
https://doaj.org/article/f2a52140da1e424a8aff2a3ac40ccfd4
Autor:
Guanjue Xiang, Xi He, Belinda M. Giardine, Kathryn J. Weaver, Dylan J. Taylor, Rajiv C. McCoy, Camden Jansen, Cheryl A. Keller, Alexander Q. Wixom, April Cockburn, Amber Miller, Qian Qi, Yanghua He, Yichao Li, Jens Lichtenberg, Elisabeth F. Heuston, Stacie M. Anderson, Jing Luan, Marit W. Vermunt, Feng Yue, Michael E.G. Sauria, Michael C. Schatz, James Taylor, Berthold Göttgens, Jim R. Hughes, Douglas R. Higgs, Mitchell J. Weiss, Yong Cheng, Gerd A. Blobel, David Bodine, Yu Zhang, Qunhua Li, Shaun Mahony, Ross C. Hardison
Knowledge of locations and activities ofcis-regulatory elements (CREs) is needed to decipher basic mechanisms of gene regulation and to understand the impact of genetic variants on complex traits. Previous studies identified candidate CREs (cCREs) us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef37c806f6c18c3930749db34dc396f5
https://doi.org/10.1101/2023.04.02.535219
https://doi.org/10.1101/2023.04.02.535219
Autor:
Pieterjan Dierickx, Kun Zhu, Bryce J. Carpenter, Chunjie Jiang, Marit W. Vermunt, Yang Xiao, Timothy S. Luongo, Tsunehisa Yamamoto, Íngrid Martí-Pàmies, Sobuj Mia, Mary Latimer, Abhinav Diwan, Juanjuan Zhao, Amy K. Hauck, Brianna Krusen, Hoang C. B. Nguyen, Gerd A. Blobel, Daniel P. Kelly, Liming Pei, Joseph A. Baur, Martin E. Young, Mitchell A. Lazar
Publikováno v:
Nature Cardiovascular Research. 1:45-58
Autor:
Jing Luan, Marit W. Vermunt, Camille M. Syrett, Allison Coté, Jacob M. Tome, Haoyue Zhang, Anran Huang, Jennifer M. Luppino, Cheryl A. Keller, Belinda M. Giardine, Shiping Zhang, Margaret C. Dunagin, Zhe Zhang, Eric F. Joyce, John T. Lis, Arjun Raj, Ross C. Hardison, Gerd A. Blobel
Publikováno v:
Nat Struct Mol Biol
Transcription at most promoters is divergent, initiating at closely spaced oppositely oriented core promoters to produce sense transcripts along with often unstable upstream antisense transcripts (uasTrx). How antisense transcription is regulated and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875560af4f05b41231d06865134f4090
https://europepmc.org/articles/PMC10015438/
https://europepmc.org/articles/PMC10015438/
Autor:
Marit W. Vermunt, Jing Luan, Zhe Zhang, A. Josephine Thrasher, Anran Huang, Megan S. Saari, Eugene Khandros, Robert A. Beagrie, Shiping Zhang, Pranay Vemulamada, Matilda Brilleman, Kiwon Lee, Jennifer A. Yano, Belinda M. Giardine, Cheryl A. Keller, Ross C. Hardison, Gerd A. Blobel
Publikováno v:
Molecular Cell. 83:715-730.e6
Autor:
John J. Ely, Alexey Kozlenkov, Michael Wegner, Marit W. Vermunt, Ke Hao, Patrick R. Hof, Eugene V. Koonin, Chet C. Sherwood, Jun-Hao Li, Eran A. Mukamel, Stella Dracheva, Pasha Apontes, Menno P. Creyghton
Publikováno v:
Proceedings of the National Academy of Sciences of the U.S.A., 117(45), 28422-28432. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 45
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 45
Proceedings of the National Academy of Sciences of the United States of America
Significance The cerebral cortex of the human brain is a highly complex, heterogeneous tissue that contains many cell types that are exquisitely regulated at the level of gene expression by noncoding regulatory elements, presumably in a cell-type–d
Autor:
Pieterjan, Dierickx, Kun, Zhu, Bryce J, Carpenter, Chunjie, Jiang, Marit W, Vermunt, Yang, Xiao, Timothy S, Luongo, Tsunehisa, Yamamoto, Íngrid, Martí-Pàmies, Sobuj, Mia, Mary, Latimer, Abhinav, Diwan, Juanjuan, Zhao, Amy K, Hauck, Brianna, Krusen, Hoang C B, Nguyen, Gerd A, Blobel, Daniel P, Kelly, Liming, Pei, Joseph A, Baur, Martin E, Young, Mitchell A, Lazar
Publikováno v:
Nature cardiovascular research. 1(1)
The heart is a highly metabolic organ that uses multiple energy sources to meet its demand for ATP production. Diurnal feeding-fasting cycles result in substrate availability fluctuations which, together with increased energetic demand during the act