Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Marit E. Geijer"'
Autor:
Barbara Steurer, Roel C. Janssens, Marit E. Geijer, Fernando Aprile-Garcia, Bart Geverts, Arjan F. Theil, Barbara Hummel, Martin E. van Royen, Bastiaan Evers, René Bernards, Adriaan B. Houtsmuller, Ritwick Sawarkar, Jurgen Marteijn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
DNA damage inhibits elongating RNA polymerase II, but also initiates genome-wide transcriptional responses. Here the authors reveal that particularly promoter-bound Pol II is degraded upon DNA damage in a GSK3 signaling-mediated response.
Externí odkaz:
https://doaj.org/article/8ae0ddc4ec8841d3a8a8b7435095a252
Autor:
Marit E Geijer, Nynke Moelijker, Gaonan Zhang, Remco Derr, Torben Osterlund, Giel Hendriks, Inger Brandsma
Publikováno v:
Toxicological Sciences. 186:288-297
Aneuploidy is characterized by the presence of an abnormal number of chromosomes and is a common hallmark of cancer. However, exposure to aneugenic compounds does not necessarily lead to cancer. Aneugenic compounds are mainly identified using the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800e6cbbaf1901026fe5d00d7280835f
https://doi.org/10.1093/toxsci/kfac008
https://doi.org/10.1093/toxsci/kfac008
Autor:
Wenzhi Gong, Richard Mitter, Wim Vermeulen, Dalton A Plummer, Chirantani Mukherjee, Marvin van Toorn, Karel Bezstarosti, Jesper Q. Svejstrup, Arjan F. Theil, Arnab Ray Chaudhuri, Anja Raams, Melanie van der Woude, John J. Wyrick, René Bernards, Yannick P Kok, Marcel A. T. M. van Vugt, Jurgen A. Marteijn, Barbara Steurer, Simona Cugusi, Adriaan B Houtsmuller, Jeroen Demmers, Shisheng Li, Joyce H.G. Lebbink, Kathiresan Selvam, Bart Geverts, Hannes Lans, Roel C. Janssens, Marit E. Geijer, Di Zhou, Bastiaan Evers, Calvin Shun Yu Lo
Publikováno v:
Nature Cell Biology, 23(6), 608-619. Nature Publishing Group
Nature cell biology
Nat Cell Biol
Nature cell biology
Nat Cell Biol
Correct transcription is crucial for life. However, DNA damage severely impedes elongating RNA polymerase II, causing transcription inhibition and transcription-replication conflicts. Cells are equipped with intricate mechanisms to counteract the sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8be2132ea5385e582a7d0be3b3d819
https://doi.org/10.1038/s41556-021-00692-z
https://doi.org/10.1038/s41556-021-00692-z
Autor:
René Bernards, Anja Raams, Jurgen A. Marteijn, Jesper Q. Svejstrup, Di Zhou, Arnab Ray Chaudhuri, Chirantani Mukherjee, Marvin van Toorn, Melanie van der Woude, Barbara Steurer, Arjan F. Theil, Wim Vermeulen, Joyce H.G. Lebbink, Kathiresan Selvam, Simona Cugusi, Adriaan B. Houtsmuller, Bart Geverts, Shisheng Li, Marit E. Geijer, Karel Bezstarosti, Bastiaan Evers, Hannes Lans, Jeroen Demmers, Roel C. Janssens, John J. Wyrick, Wenzhi Gong, Richard Mitter, Dalton A Plummer
Correct transcription is crucial for life. However, DNA damage severely impedes elongating RNA Polymerase II (Pol II), causing transcription inhibition and transcription-replication conflicts. Cells are equipped with intricate mechanisms to counterac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cae2bdda9091fcb8bbddab66b9eb692
https://doi.org/10.1101/2021.05.11.443558
https://doi.org/10.1101/2021.05.11.443558
Autor:
Marit E. Geijer, Jurgen A. Marteijn
Publikováno v:
DNA Repair, 71, 56-68. Elsevier
Unperturbed transcription of eukaryotic genes by RNA polymerase II (Pol II) is crucial for proper cell function and tissue homeostasis. However, the DNA template of Pol II is continuously challenged by damaging agents that can result in transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47aab839f0e79107a3343c44b2658495
https://doi.org/10.1016/j.dnarep.2018.08.007
https://doi.org/10.1016/j.dnarep.2018.08.007
Autor:
René Bernards, Bastiaan Evers, Calvin Shun Yu Lo, Joyce H.G. Lebbink, Simona Cugusi, Arnab Ray Chaudhuri, Anja Raams, John J. Wyrick, Bart Geverts, Marit E. Geijer, Wenzhi Gong, Wim Vermeulen, Jesper Q. Svejstrup, Hannes Lans, Melanie van der Woude, Marvin van Toorn, Shisheng Li, Roel C. Janssens, Marcel A. T. M. van Vugt, Chirantani Mukherjee, Karel Bezstarosti, Richard Mitter, Dalton A Plummer, Arjan F. Theil, Barbara Steurer, Kathiresan Selvam, Yannick P Kok, Adriaan B Houtsmuller, Di Zhou, Jurgen A. Marteijn, Jeroen Demmers
Publikováno v:
Nature Cell Biology. 23:809-809
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1acba5da39cdf888ee317c770a6b5f0
https://doi.org/10.1038/s41556-021-00720-y
https://doi.org/10.1038/s41556-021-00720-y
Autor:
Barbara Steurer, Shannon Dealy, Roel C. Janssens, Franziska Wienholz, Arjan F. Theil, Marit E. Geijer, Wiggert A. van Cappellen, Bart Geverts, Adriaan B. Houtsmuller, Jiang Chang, Jurgen A. Marteijn, Joris Pothof
Publikováno v:
Proceedings of the National Academy of Sciences of the U.S.A., 115(19), E4368-E4376. National Academy of Sciences
Initiation and promoter-proximal pausing are key regulatory steps of RNA Polymerase II (Pol II) transcription. To study the in vivo dynamics of endogenous Pol II during these steps, we generated fully functional GFP-RPB1 knockin cells. GFP-RPB1 photo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d4a4418bae411475f1d7424301ea803
https://pubmed.ncbi.nlm.nih.gov/29691322
https://pubmed.ncbi.nlm.nih.gov/29691322