Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Marissa Vavrek"'
Autor:
Manuel de Lera Ruiz, Paola Favuzza, Zhuyan Guo, Lianyun Zhao, Bin Hu, Zhiyu Lei, Dongmei Zhan, Nicholas Murgolo, Christopher W. Boyce, Marissa Vavrek, Jennifer Thompson, Anna Ngo, Kate E. Jarman, Johnathan Robbins, Justin Boddey, Brad E. Sleebs, Kym N. Lowes, Alan F. Cowman, David B. Olsen, John A. McCauley
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1745-1754
Drug resistance to first-line antimalarials-including artemisinin-is increasing, resulting in a critical need for the discovery of new agents with novel mechanisms of action. In collaboration with the Walter and Eliza Hall Institute and with funding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5c87b18003c3926bf80d926fcdff26
https://doi.org/10.1021/acsmedchemlett.2c00355
https://doi.org/10.1021/acsmedchemlett.2c00355
Autor:
Gregory L. Adams, Parul S. Pall, Steven M. Grauer, Xiaoping Zhou, Jeanine E. Ballard, Marissa Vavrek, Richard L. Kraus, Pierre Morissette, Nianyu Li, Stefania Colarusso, Elisabetta Bianchi, Anandan Palani, Rebecca Klein, Christopher T. John, Deping Wang, Matthew Tudor, Andrew F. Nolting, Mirlinda Biba, Timothy Nowak, Alexey A. Makarov, Mikhail Reibarkh, Alexei V. Buevich, Wendy Zhong, Erik L. Regalado, Xiao Wang, Qi Gao, Aurash Shahripour, Yuping Zhu, Daniele de Simone, Tommaso Frattarelli, Nicolo’ Maria Pasquini, Paola Magotti, Roberto Iaccarino, Yuxing Li, Kelli Solly, Keun-Joong Lee, Weixun Wang, Feifei Chen, Haoyu Zeng, Jixin Wang, Hilary Regan, Rupesh P. Amin, Christopher P. Regan, Christopher S. Burgey, Darrell A. Henze, Chengzao Sun, David M. Tellers
Publikováno v:
Journal of Medicinal Chemistry. 65:485-496
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ecd04283fe1d38ba43c9ca77818a20e
https://doi.org/10.1021/acs.jmedchem.1c01570
https://doi.org/10.1021/acs.jmedchem.1c01570
Publikováno v:
Analytica Chimica Acta. 1125:279-287
Peptides have become a fast-growing segment of the pharmaceutical industry over the past few decades. It is essential to develop cutting edge analytical techniques to support the discovery and development of peptide therapeutics, especially to examin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450c62b61bb400ff684ac27e1d425829
https://doi.org/10.1016/j.aca.2020.05.050
https://doi.org/10.1016/j.aca.2020.05.050
Publikováno v:
Journal of the American Society for Mass Spectrometry. 31:2558-2562
dropletProbe mass spectrometry (MS) is an emerging tool for the rapid ex vivo analysis of drugs in tissues and whole-body sections. Its use has been demonstrated to better understand a drug's absorption, distribution, metabolism, and excretion (ADME)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc4a0757321a2275c297267e62d2f412
https://doi.org/10.1021/jasms.0c00168
https://doi.org/10.1021/jasms.0c00168
Autor:
Gregory L, Adams, Parul S, Pall, Steven M, Grauer, Xiaoping, Zhou, Jeanine E, Ballard, Marissa, Vavrek, Richard L, Kraus, Pierre, Morissette, Nianyu, Li, Stefania, Colarusso, Elisabetta, Bianchi, Anandan, Palani, Rebecca, Klein, Christopher T, John, Deping, Wang, Matthew, Tudor, Andrew F, Nolting, Mirlinda, Biba, Timothy, Nowak, Alexey A, Makarov, Mikhail, Reibarkh, Alexei V, Buevich, Wendy, Zhong, Erik L, Regalado, Xiao, Wang, Qi, Gao, Aurash, Shahripour, Yuping, Zhu, Daniele, de Simone, Tommaso, Frattarelli, Nicolo' Maria, Pasquini, Paola, Magotti, Roberto, Iaccarino, Yuxing, Li, Kelli, Solly, Keun-Joong, Lee, Weixun, Wang, Feifei, Chen, Haoyu, Zeng, Jixin, Wang, Hilary, Regan, Rupesh P, Amin, Christopher P, Regan, Christopher S, Burgey, Darrell A, Henze, Chengzao, Sun, David M, Tellers
Publikováno v:
Journal of medicinal chemistry. 65(1)
Inhibitor cystine knot peptides, derived from venom, have evolved to block ion channel function but are often toxic when dosed at pharmacologically relevant levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f03f2c5f5119ec1a76291dcc4081ccf8
https://pubmed.ncbi.nlm.nih.gov/34931831
https://pubmed.ncbi.nlm.nih.gov/34931831
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2437
dropletProbe mass spectrometry is a novel technique for molecular characterization of surfaces. It can be used for rapid ex vivo analysis of therapeutics from thin animal tissue sections and has been shown to improve understanding of a drug's absorpt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16dacfaaafddd33c4f17eefc0cc504a9
https://pubmed.ncbi.nlm.nih.gov/34902148
https://pubmed.ncbi.nlm.nih.gov/34902148
Autor:
Marissa Vavrek, Bingming Chen, Charles Collier, Vilmos Kertesz, John F. Cahill, Bernadeta R. Srijanto
Publikováno v:
Rapid Communications in Mass Spectrometry. 35
RATIONALE Spatially resolved and accurate quantitation of drug-related compounds in tissue is a much-needed capability in drug discovery research. Here, application of an integrated laser ablation-dropletProbe-mass spectrometry surface sampling syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f4149ddeb86b1a0f25e07d67be4cb4a
https://doi.org/10.1002/rcm.9202
https://doi.org/10.1002/rcm.9202
Publikováno v:
International Journal of Mass Spectrometry. 437:17-22
The application of a fully automated autosampler/HPLC-ESI–MS/MS system for spatially resolved quantitative droplet-based liquid extraction surface sampling/profiling of stapled α–helical peptide ATSP-7041 in mouse whole-body thin tissue sections
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f3c9b3ce22e5918237892d5bd717799
https://doi.org/10.1016/j.ijms.2018.01.005
https://doi.org/10.1016/j.ijms.2018.01.005
Autor:
Baojen Shyong, Fangbiao Li, Daniela Mesa Sanchez, Ruichuan Yin, Mark T. Cancilla, Rena Zhang, Hilary Brown, Marissa Vavrek, Julia Laskin, Bingming Chen, Wendy Zhong
Glucuronidation is a common phase II metabolic process for drugs and xenobiotics which increases their solubility for excretion. Acyl glucuronides (glucuronides of carboxylic acids) present concerns of toxicity as they have been implicated in gastroi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe95ebea93fa9e442bb505ae64ac880
https://doi.org/10.26434/chemrxiv.13194422
https://doi.org/10.26434/chemrxiv.13194422
