Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Marissa S. Mattar"'
Autor:
Dylan A. Farnsworth, Yusuke Inoue, Fraser D. Johnson, Georgia de Rappard-Yuswack, Daniel Lu, Rocky Shi, Lok In Josephine Ma, Marissa S. Mattar, Romel Somwar, Marc Ladanyi, Arun M. Unni, William W. Lockwood
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-15 (2022)
Abstract MEK inhibitors (MEKi) have limited efficacy in KRAS mutant lung adenocarcinoma (LUAD) patients, and this is attributed to both intrinsic and adaptive mechanisms of drug resistance. While many studies have focused on the former, there remains
Externí odkaz:
https://doaj.org/article/d1bc38b675aa48b9b89c98c59ec5707a
Autor:
Romel Somwar, Nicolle E. Hofmann, Bryan Smith, Igor Odintsov, Morana Vojnic, Irina Linkov, Ashley Tam, Inna Khodos, Marissa S. Mattar, Elisa de Stanchina, Daniel Flynn, Marc Ladanyi, Alexander Drilon, Ujwal Shinde, Monika A. Davare
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Romel Somwar et al. find that cancer-causing NTRK gene fusions resistant to one form of inhibitor therapy can be resistant to other inhibitor types. Using molecular simulations, they show that some NTRK1 mutations resistant to the type I inhibitor la
Externí odkaz:
https://doaj.org/article/dc4dd666029c45298c0ddd64355c90c2
Autor:
Roger S. Smith, Igor Odintsov, Zebing Liu, Allan Jo-Weng Lui, Takuo Hayashi, Morana Vojnic, Yoshiyuki Suehara, Lukas Delasos, Marissa S. Mattar, Julija Hmeljak, Hillary A. Ramirez, Melissa Shaw, Gabrielle Bui, Alifiani B. Hartono, Eric Gladstone, Siddharth Kunte, Heather Magnan, Inna Khodos, Elisa De Stanchina, Michael P. La Quaglia, Jinjuan Yao, Marick Laé, Sean B. Lee, Lee Spraggon, Christine A. Pratilas, Marc Ladanyi, Romel Somwar
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 1 (2022)
Desmoplastic small round cell tumor (DSRCT) is characterized by the t(11;22)(p13;q12) translocation, which fuses the transcriptional regulatory domain of EWSR1 with the DNA-binding domain of WT1, resulting in the oncogenic EWSR1-WT1 fusion protein. T
Externí odkaz:
https://doaj.org/article/7b83f47a6c8e4d5eb829d9ab77a3d402
Autor:
Takuo Hayashi, Igor Odintsov, Roger S. Smith, Kota Ishizawa, Allan J. W. Liu, Lukas Delasos, Christopher Kurzatkowski, Huichun Tai, Eric Gladstone, Morana Vojnic, Shinji Kohsaka, Ken Suzawa, Zebing Liu, Siddharth Kunte, Marissa S. Mattar, Inna Khodos, Monika A. Davare, Alexander Drilon, Emily Cheng, Elisa de Stanchina, Marc Ladanyi, Romel Somwar
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 2 (2021)
Multi-kinase RET inhibitors, such as cabozantinib and RXDX-105, are active in lung cancer patients with RET fusions; however, the overall response rates to these two drugs are unsatisfactory compared to other targeted therapy paradigms. Moreover, the
Externí odkaz:
https://doaj.org/article/2e7e848718f248f5b1b70bad579df39d
Autor:
Romel Somwar, Alexander Drilon, Marc Ladanyi, Eileen M. O'Reilly, Elisa de Stanchina, Ernesto Wasserman, Jeroen J. Lammerts van Bueren, Ron C.J. Schackmann, Cecile A.W. Geuijen, Marie N. O'Connor, Jim Ford, Jean Torrisi, Thrusha Chauhan, Sara H. Shameem, Morana Vojnic, Allan J.W. Lui, Marissa S. Mattar, Whitney J. Sisso, Inna Khodos, Madelyn Espinosa-Cotton, Igor Odintsov, Alison M. Schram
Supplementary Figure from Zenocutuzumab, a HER2xHER3 Bispecific Antibody, Is Effective Therapy for Tumors Driven by NRG1 Gene Rearrangements
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957edba211dae8e33116bb0bbf5e53e7
https://doi.org/10.1158/2159-8290.22541186.v1
https://doi.org/10.1158/2159-8290.22541186.v1
Autor:
Romel Somwar, Alexander Drilon, Marc Ladanyi, Eileen M. O'Reilly, Elisa de Stanchina, Ernesto Wasserman, Jeroen J. Lammerts van Bueren, Ron C.J. Schackmann, Cecile A.W. Geuijen, Marie N. O'Connor, Jim Ford, Jean Torrisi, Thrusha Chauhan, Sara H. Shameem, Morana Vojnic, Allan J.W. Lui, Marissa S. Mattar, Whitney J. Sisso, Inna Khodos, Madelyn Espinosa-Cotton, Igor Odintsov, Alison M. Schram
NRG1 rearrangements are recurrent oncogenic drivers in solid tumors. NRG1 binds to HER3, leading to heterodimerization with other HER/ERBB kinases, increased downstream signaling, and tumorigenesis. Targeting ERBBs, therefore, represents a therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ad90ec0c5517efbc60698dfdb31aea
https://doi.org/10.1158/2159-8290.c.6549563.v1
https://doi.org/10.1158/2159-8290.c.6549563.v1
Autor:
Monika A. Davare, Romel Somwar, Marc Ladanyi, Gregory J. Riely, Alexander Drilon, Inna Khodos, Elisa de Stanchina, Marissa S. Mattar, Evan Siau, Adam J. Schoenfeld, Igor Odintsov, Sudarshan R. Iyer
Supplementary Figure from MYC Promotes Tyrosine Kinase Inhibitor Resistance in ROS1-Fusion-Positive Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14cd1cbc3ae3a642d3da55c2f8fffbf3
https://doi.org/10.1158/1541-7786.22527461.v1
https://doi.org/10.1158/1541-7786.22527461.v1
Autor:
Monika A. Davare, Romel Somwar, Marc Ladanyi, Gregory J. Riely, Alexander Drilon, Inna Khodos, Elisa de Stanchina, Marissa S. Mattar, Evan Siau, Adam J. Schoenfeld, Igor Odintsov, Sudarshan R. Iyer
Supplementary Data from MYC Promotes Tyrosine Kinase Inhibitor Resistance in ROS1-Fusion-Positive Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022a965ac8a56c0d552f81232d4c5fa9
https://doi.org/10.1158/1541-7786.22527473
https://doi.org/10.1158/1541-7786.22527473
Autor:
Romel Somwar, Marc Ladanyi, Julia L. Glade Bender, Elisa de Stanchina, Shinji Kohsaka, Allan J.W. Lui, Marissa S. Mattar, Inna Khodos, Michael V. Ortiz, Igor Odintsov
Supplementary Figure from CIC-Mediated Modulation of MAPK Signaling Opposes Receptor Tyrosine Kinase Inhibitor Response in Kinase-Addicted Sarcoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bcc6718e6b29150fd530d2bb46f5c42
https://doi.org/10.1158/0008-5472.22431420
https://doi.org/10.1158/0008-5472.22431420
Autor:
Marc Ladanyi, Lee Spraggon, Sean Bong Lee, Christine A. Pratilas, Emily Slotkin, Michael P. LaQuaglia, Alifiani B. Hartono, Igor Odintsov, Marina Asher, Achim Jungbluth, Elisa de Stanchina, Inna Khodos, Marissa S. Mattar, Anita S. Bowman, Amir Momeni Boroujeni, Ryma Benayed, Heather Magnan, Julija Hmeljak, Romel Somwar, Koichi Ogura
Supplementary Table 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e945237e14caf95f561f8f08c739da
https://doi.org/10.1158/1078-0432.22478247.v1
https://doi.org/10.1158/1078-0432.22478247.v1