Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Marissa Mock"'
Autor:
Emily K. Makowski, Hsin-Ting Chen, Tiexin Wang, Lina Wu, Jie Huang, Marissa Mock, Patrick Underhill, Emma Pelegri-O’Day, Erick Maglalang, Dwight Winters, Peter M. Tessier
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTEarly identification of antibody candidates with drug-like properties is essential for simplifying the development of safe and effective antibody therapeutics. For subcutaneous administration, it is important to identify candidates with low s
Externí odkaz:
https://doaj.org/article/36271266403a4691a2dd72e35b369f74
Autor:
Shufang Liu, Sara C. Humphreys, Kevin D. Cook, Kip P. Conner, Ana R. Correia, Alex W. Jacobitz, Melissa Yang, Ronya Primack, Marcus Soto, Rupa Padaki, Mariusz Lubomirski, Richard Smith, Marissa Mock, Veena A. Thomas
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTIn this investigation, we tested the hypothesis that a physiologically based pharmacokinetic (PBPK) model incorporating measured in vitro metrics of off-target binding can largely explain the inter-antibody variability in monoclonal antibody
Externí odkaz:
https://doaj.org/article/ba5447ad553b4a998a1ea0915308c3b4
Autor:
Marissa Mock, Alex W. Jacobitz, Christopher James Langmead, Athena Sudom, Daniel Yoo, Sara C. Humphreys, Mai Alday, Larysa Alekseychyk, Nicolas Angell, Vivian Bi, Hannah Catterall, Chen-Chun Chen, Hui-Ting Chou, Kip P. Conner, Kevin D. Cook, Ana R. Correia, Andrew Dykstra, Sudipa Ghimire-Rijal, Kevin Graham, Peter Grandsard, Joon Huh, John O. Hui, Mani Jain, Victoria Jann, Lei Jia, Sheree Johnstone, Neelam Khanal, Carl Kolvenbach, Linda Narhi, Rupa Padaki, Emma M. Pelegri-O’Day, Wei Qi, Vladimir Razinkov, Austin J. Rice, Richard Smith, Christopher Spahr, Jennitte Stevens, Yax Sun, Veena A. Thomas, Sarah van Driesche, Robert Vernon, Victoria Wagner, Kenneth W. Walker, Yangjie Wei, Dwight Winters, Melissa Yang, Iain D. G. Campuzano
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTBiologic drug discovery pipelines are designed to deliver protein therapeutics that have exquisite functional potency and selectivity while also manifesting biophysical characteristics suitable for manufacturing, storage, and convenient admin
Externí odkaz:
https://doaj.org/article/c7e86c82a6684b888888da7d561e8891
Autor:
Riti Biswas, Ed Belouski, Kevin Graham, Michelle Hortter, Marissa Mock, Christine E. Tinberg, Alan J. Russell
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTWe are entering an era in which therapeutic proteins are assembled using building block-like strategies, with no standardized schema to discuss these formats. Existing nomenclatures, like AbML, sacrifice human readability for precision. There
Externí odkaz:
https://doaj.org/article/a742f5fea5fa4f1dba7e11771a364ca2
Autor:
Ruoyu Jiang, Paul Yoo, Abhinand M. Sudarshana, Emma Pelegri-O'Day, Sandeep Chhabra, Marissa Mock, Abraham P. Lee
Publikováno v:
Lab on a Chip.
We introduce μVAST, a high-throughput acoustic microstreaming platform using second-order microstreaming to induce fluid transport and measure the viscosity of 16 samples, automating process flows in drug development, materials manufacturing and pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d38fa26c68e1a60c853f2925145899ef
https://doi.org/10.1039/d3lc00101f
https://doi.org/10.1039/d3lc00101f
Autor:
Les P. Miranda, Ching Chen, Irwin Chen, Philip Jess, Aaron George Winters, Christopher Tan, Ming C. Wu, Philip Tagari, Fen-Fen Lin, Agi Hamburger, Jennitte Stevens, Marissa Mock, J. Tanner Nevill, Trent P. Munro, Su Chong, Kim Le, Marsela Jorgolli, Han Xu
Publikováno v:
Biotechnology and bioengineering, vol 116, iss 9
Biotechnology and Bioengineering
Biotechnology and Bioengineering
The new and rapid advancement in the complexity of biologics drug discovery has been driven by a deeper understanding of biological systems combined with innovative new therapeutic modalities, paving the way to breakthrough therapies for previously i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e07e72f8576073b9d8d46772f87032
https://doi.org/10.1002/bit.27024
https://doi.org/10.1002/bit.27024
Autor:
René Hubert, Cai Guo, Fuyi Chen, Hannah B Catterall, Zhulun Wang, John H. Robinson, Qiang Xiao, Marissa Mock
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 118(10)
Multispecific antibodies, often composed of three to five polypeptide chains, have become increasingly relevant in the development of biotherapeutics. These molecules have mechanisms of action that include redirecting T cells to tumors and blocking m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e4b1de825a7b4a430d2246b926041d
https://pubmed.ncbi.nlm.nih.gov/34110008
https://pubmed.ncbi.nlm.nih.gov/34110008
Autor:
Marsela Jorgolli, Tanner Nevill, Aaron Winters, Irwin Chen, Su Chong, Fen‐Fen Lin, Marissa Mock, Ching Chen, Kim Le, Christopher Tan, Philip Jess, Han Xu, Agi Hamburger, Jennitte Stevens, Trent Munro, Ming Wu, Philip Tagari, Les P. Miranda
Publikováno v:
Biotechnology and Bioengineering. 116
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf8c50029c5ce7b02bf8e0f36705a5b5
https://doi.org/10.1002/bit.26764
https://doi.org/10.1002/bit.26764
Publikováno v:
Journal of Macromolecular Science, Part B. 38:403-417
Oxidation reactions are one of the main reasons for the failure of polymeric materials. Antioxidants, compounds designed to protect against oxidation, must meet three main requirements for success: (1) an efficient antioxidative mechanism, (2) compat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29445cd8808669022cd65662888e87c1
https://doi.org/10.1080/00222349908212440
https://doi.org/10.1080/00222349908212440
Publikováno v:
Nature. 451(7174)
Aminoacyl-tRNA synthetases attach amino acids to tRNAs. Occasionally, an incorrect amino acid will attached to the wrong tRNA, and this must be reversed, or edited, to prevent the wrong amino acid from being incorporated into protein. This paper show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36363ecf0dfea7fc01c44eb1374414e9
https://pubmed.ncbi.nlm.nih.gov/18172502
https://pubmed.ncbi.nlm.nih.gov/18172502