GAF is essential for zygotic genome activation and chromatin accessibility in the early Drosophila embryo

Autor: Marissa M Gaskill, Tyler J Gibson, Elizabeth D Larson, Melissa M Harrison

Publikováno v: eLife, Vol 10 (2021)

Following fertilization, the genomes of the germ cells are reprogrammed to form the totipotent embryo. Pioneer transcription factors are essential for remodeling the chromatin and driving the initial wave of zygotic gene expression. In Drosophila mel

Externí odkaz: https://doaj.org/article/934df474a8e741bcb8e2dcf80fed6838

Localization of the pioneer factor GAF to subnuclear foci is driven by DNA binding and required to silence satellite repeat expression

Autor: Marissa. M. Gaskill, Isabella V. Soluri, Annemarie E. Branks, Alan P. Boka, Michael R. Stadler, Katherine Vietor, Hao-Yu S. Huang, Tyler J. Gibson, Mustafa Mir, Shelby A. Blythe, Melissa M. Harrison

/SummaryThe eukaryotic genome is organized to enable the precise regulation of gene expression required for development. This organization is established during early development when the embryo transitions from a fertilized germ cell to the totipote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f3267f26c9efa30151a8e471cae5ccc
https://doi.org/10.1101/2022.11.29.518380

The control of transcriptional memory by stable mitotic bookmarking

Autor: Mounia Lagha, Melissa M. Harrison, George Hunt, Jeremy Dufourt, Antonio Trullo, Maelle Bellec, Cyril Favard, Jean-Christophe Andrau, Ovidiu Radulescu, Mattias Mannervik, Hélène Lenden-Hasse, Marissa M Gaskill, Marie Lamarque, Heloïse Faure-Gautron, Amal Zine El Aabidine

To maintain cellular identities during development, gene expression profiles must be faithfully propagated through cell generations. The reestablishment of gene expression patterns upon mitotic exit is thought to be mediated, in part, by mitotic book

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16e2fe8fe379eef7b0a98169c3360992
https://hal.archives-ouvertes.fr/hal-03442288

GAF is essential for zygotic genome activation and chromatin accessibility in the early Drosophila embryo

Autor: Melissa Harrison, Tyler J. Gibson, Elizabeth D. Larson, Marissa M Gaskill

Publikováno v: eLife, Vol 10 (2021)
eLife

Following fertilization, the genomes of the germ cells are reprogrammed to form the totipotent embryo. Pioneer transcription factors are essential for remodeling the chromatin and driving the initial wave of zygotic gene expression. In Drosophila mel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e26aeef95c8887fa7c459559907484b
https://elifesciences.org/articles/66668

Tethering gene regulation to chromatin organization.

Autor: Gaskill M; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA., Harrison M; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2022 Feb 04; Vol. 375 (6580), pp. 491-492. Date of Electronic Publication: 2022 Feb 03.