Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Marissa Leonard"'
Autor:
Yongguang Yang, Marissa Leonard, Zhenhua Luo, Syn Yeo, Gregory Bick, Mingang Hao, Chunmiao Cai, Mahmoud Charif, Jiang Wang, Jun-Lin Guan, Elyse E. Lower, Xiaoting Zhang
Publikováno v:
Cell Reports, Vol 34, Iss 10, Pp 108822- (2021)
Summary: MED1 (mediator subunit 1) co-amplifies with HER2, but its role in HER2-driven mammary tumorigenesis is still unknown. Here, we generate MED1 mammary-specific overexpression mice and cross them with mouse mammary tumor virus (MMTV)-HER2 mice.
Externí odkaz:
https://doaj.org/article/7c097196109c4077a33168b50f10e347
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70641 (2013)
Pure anti-estrogen fulvestrant has been shown to be a promising ER antagonist for locally advanced and metastatic breast cancer. Unfortunately, a significant proportion of patients developed resistance to this type of endocrine therapy but the molecu
Externí odkaz:
https://doaj.org/article/18c2394374ba44ebac735d45666446d3
Autor:
Xiaoting Zhang, Elyse E. Lower, Jiang Wang, Shugufta Khan, Charif Mahmoud, Dan Zhao, Yijuan Zhang, Marissa Leonard, Yongguang Yang
Studies of the estrogen receptor (ER) coactivator protein Mediator subunit 1 (MED1) have revealed its specific roles in pubertal mammary gland development and potential contributions to breast tumorigenesis, based on coamplification of MED1 and HER2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3994d725d906c9285af021e262b06035
https://doi.org/10.1158/0008-5472.c.6509763
https://doi.org/10.1158/0008-5472.c.6509763
Autor:
Xiaoting Zhang, Elyse E. Lower, Jiang Wang, Shugufta Khan, Charif Mahmoud, Dan Zhao, Yijuan Zhang, Marissa Leonard, Yongguang Yang
Supplementary Information - This file contains Supplemental Procedures, Supplemental References, Supplemental Table1, Supplementary Figure Legends, and Supplementary Figures. Supplemental Procedure describes the methods and PCR primers used in this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad1c6ca7fdf4f39333d7fb651b6c27c
https://doi.org/10.1158/0008-5472.22417173.v1
https://doi.org/10.1158/0008-5472.22417173.v1
Autor:
Elyse E. Lower, Jiang Wang, Gregory Bick, Chunmiao Cai, Syn Kok Yeo, Mingang Hao, Yongguang Yang, Zhenhua Luo, Marissa Leonard, Mahmoud Charif, Xiaoting Zhang, Jun-Lin Guan
Publikováno v:
Cell reports
Cell Reports, Vol 34, Iss 10, Pp 108822-(2021)
Cell Reports, Vol 34, Iss 10, Pp 108822-(2021)
SUMMARY MED1 (mediator subunit 1)co-amplifies with HER2, but its role in HER2-driven mammary tumorigenesis is still unknown. Here, we generate MED1 mammary-specific overexpression mice and cross them with mouse mammary tumor virus (MMTV)-HER2 mice. W
Autor:
Marissa Leonard, Xiaoting Zhang, Charif Mahmoud, Elyse E. Lower, Dan Zhao, Yijuan Zhang, Yongguang Yang, Jiang Wang, Shugufta Khan
Publikováno v:
Cancer Research. 78:422-435
Studies of the estrogen receptor (ER) coactivator protein Mediator subunit 1 (MED1) have revealed its specific roles in pubertal mammary gland development and potential contributions to breast tumorigenesis, based on coamplification of MED1 and HER2
Publikováno v:
ACS Nano. 11:335-346
Most breast cancers express estrogen receptor (ER) α, and the antiestrogen drug tamoxifen has been widely used for their treatment. Unfortunately, up to half of all ERα-positive tumors have intrinsic or acquired endocrine therapy resistance. Our re
Autor:
Xiaoting Zhang, Marissa Leonard
Publikováno v:
Journal of Zhejiang University. Science. B. 20(5)
Breast cancer, one of the most frequent cancer types, is a leading cause of death in women worldwide. Estrogen receptor (ER) α is a nuclear hormone receptor that plays key roles in mammary gland development and breast cancer. About 75% of breast can
Publikováno v:
Estrogen Receptor and Breast Cancer ISBN: 9783319993492
Antiestrogen therapies have been a staple treatment option for estrogen receptor (ER)-positive breast cancer patients for many decades, but resistance remains a major obstacle for continued successful treatment. In this chapter, we will discuss the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::011e9dddf9a89d2af56576d8ea4403da
https://doi.org/10.1007/978-3-319-99350-8_14
https://doi.org/10.1007/978-3-319-99350-8_14
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1296
Small non-coding RNAs (sncRNAs) such as small interfering RNAs (siRNAs), microRNAs (miRNAs) and RNA aptamers have recently emerged as highly versatile and valuable tools in disease diagnostics and therapeutics, largely due to their key regulatory fun