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Autor:
Sayali S. Kukday, Walter K. Schmidt, Marissa C. Ludley, Mary E. Burriss, Benjamin J. Alper, Surya P. Manandhar
Publikováno v:
SLAS Discovery. 17:1348-1361
The insulin-degrading enzyme (IDE) cleaves numerous small peptides, including biologically active hormones and disease-related peptides. The propensity of IDE to degrade neurotoxic Aβ peptides marks IDE as a potential therapeutic target for Alzheime