Výsledky vyhledávání - "Marissa Bruno"

Akademický článek

737 A phase 1/1b study of the tumor-activated IL-2 prodrug WTX-124 alone or in combination with pembrolizumab in patients with immunotherapy-sensitive locally advanced or metastatic solid tumors

Autor: Brendan Curti, Igor Puzanov, Mateusz Opyrchal, Christopher J Nirschl, Mehmet A Bilen, Kristin Morris, Justin C Moser, Ildefonso Rodriguez Rivera, Saero Park, Marissa Bruno, Paul Windt, Kulandayan K Subramanian, Sameer S Chopra, Randi Isaacs

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Externí odkaz: https://doaj.org/article/2c535f528fe849388924b327f27fc65e

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Abstract CT254: Trial in progress: a first-in-human, phase 1, multicenter dose escalation and dose expansion study of WTX-330 in adult patients with advanced or metastatic solid tumors or non-Hodgkin lymphoma

Autor: Ildefonso Ismael Rodriguez-Rivera, Justin C. Moser, Mateusz Opyrchal, Aparna R. Parikh, Saero Park, Marissa Bruno, Paul Windt, Kulandayan K. Subramanian, Sameer S. Chopra, Randi Isaacs

Publikováno v: Cancer Research. 83:CT254-CT254

Background: Interleukin-12 (IL-12) is a potent proinflammatory cytokine with activating effects on both innate and adaptive immune cells. Though recombinant IL-12 (rIL-12) causes tumor regression with antitumor immune memory formation in a range of i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::caa94c8d8270421ee051a9f83654ad58
https://doi.org/10.1158/1538-7445.am2023-ct254

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