Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Marissa A. Holmbeck"'
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 8, Pp 843-854 (2015)
Communication between the mitochondrial and nuclear genomes is vital for cellular function. The assembly of mitochondrial enzyme complexes, which produce the majority of cellular energy, requires the coordinated expression and translation of both mit
Externí odkaz:
https://doaj.org/article/c8ec8dbd0a4c4165bbc306313da940f4
Autor:
Qin Yan, Xiang Chen, Gerald S. Shadel, David L. Rimm, David F. Stern, Michael P. DiGiovanna, Keisuke Aoshima, Swati Gupta, Mariana Do Carmo, Lizhen Wu, Sabine M. Lang, Meiling Zhang, Marissa A. Holmbeck, Zongzhi Z. Liu, Jian Cao, Yao Li, Molly Gale
Acquired resistance to HER2-targeted therapies occurs frequently in HER2+ breast tumors and new strategies for overcoming resistance are needed. Here, we report that resistance to trastuzumab is reversible, as resistant cells regained sensitivity to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::742603bf6c8428c05637f9e53de3cb10
https://doi.org/10.1158/0008-5472.c.6512016.v1
https://doi.org/10.1158/0008-5472.c.6512016.v1
Autor:
Qin Yan, Xiang Chen, Gerald S. Shadel, David L. Rimm, David F. Stern, Michael P. DiGiovanna, Keisuke Aoshima, Swati Gupta, Mariana Do Carmo, Lizhen Wu, Sabine M. Lang, Meiling Zhang, Marissa A. Holmbeck, Zongzhi Z. Liu, Jian Cao, Yao Li, Molly Gale
Supplementary Table 2: BT-TR1 versus BT474 RNA sequencing normalized gene expression Supplementary Table 3: BT-TR2 versus BT474 RNA sequencing normalized gene expression Supplementary Table 4: BT-TPR1 versus BT474 RNA sequencing normalized gene expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::325411ac839ced214980806e39f4c086
https://doi.org/10.1158/0008-5472.22425378.v1
https://doi.org/10.1158/0008-5472.22425378.v1
Autor:
Qin Yan, Xiang Chen, Gerald S. Shadel, David L. Rimm, David F. Stern, Michael P. DiGiovanna, Keisuke Aoshima, Swati Gupta, Mariana Do Carmo, Lizhen Wu, Sabine M. Lang, Meiling Zhang, Marissa A. Holmbeck, Zongzhi Z. Liu, Jian Cao, Yao Li, Molly Gale
Supplementary Figure 1: Generation and characterization of resistant cell pools. Supplementary Figure 2: Copy number assessment of receptor tyrosine kinases in resistant cell pools. Supplementary Figure 3: Trastuzumab resistance is reversible. Supple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82650a9bb458b36bd2c75909d032d29d
https://doi.org/10.1158/0008-5472.22425381
https://doi.org/10.1158/0008-5472.22425381
Autor:
David F. Stern, Lizhen Wu, Sabine Lang, Mariana Do Carmo, David L. Rimm, Gerald S. Shadel, Marissa A. Holmbeck, Yao Li, Meiling Zhang, Zongzhi Zachary Liu, Michael P. DiGiovanna, Keisuke Aoshima, Swati Gupta, Qin Yan, Jian Cao, Molly Gale, Xiang Chen
Publikováno v:
Cancer Res
Acquired resistance to HER2-targeted therapies occurs frequently in HER2+ breast tumors and new strategies for overcoming resistance are needed. Here, we report that resistance to trastuzumab is reversible, as resistant cells regained sensitivity to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c27086c4418f74be42b50fdd25f4b603
https://pubmed.ncbi.nlm.nih.gov/31690671
https://pubmed.ncbi.nlm.nih.gov/31690671
Autor:
Marissa A. Holmbeck, Gerald S. Shadel
Publikováno v:
Nature immunology. 17(9)
Macrophages tightly scale their core metabolism upon activation, but the precise regulation of the mitochondrial electron transport chain (ETC) and its functional implications are currently unknown. Here we show that recognition of live bacteria by m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b4221c6c772e849ef93b0f5f774c37
https://pubmed.ncbi.nlm.nih.gov/27348412
https://pubmed.ncbi.nlm.nih.gov/27348412
Autor:
Elizabeth S. Didier, Miguel Coelho, Iain Ridgway, Tracy T. Chow, Paul W. Whitby, Insil Kim, Eva E. R. Philipp, Philip McQuary, William E. Sonntag, Courtney M. Campbell, Sara Gelino, Zoltan Ungvari, Marissa A. Holmbeck, Danuta Sosnowska, Anna Csiszar, Steven N. Austad, Erik Levy
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 68:359-367
Bivalve species with exceptional longevity are newly introduced model systems in biogerontology to test evolutionarily conserved mechanisms of aging. Here, we tested predictions based on the oxidative stress hypothesis of aging using one of the tropi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6fe9f002bc70dba00985f80a47df37
https://doi.org/10.1093/gerona/gls159
https://doi.org/10.1093/gerona/gls159
Autor:
Insil Kim, Eva E. R. Philipp, Sara Gelino, Philip McQuary, Danuta Sosnowska, Steven N. Austad, William E. Sonntag, Tracy T. Chow, Elizabeth S. Didier, Iain Ridgway, Marissa A. Holmbeck, Zoltan Ungvari, Anna Csiszar, Erik Levy, Miguel Coelho, Courtney M. Campbell
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. :741-750
We assess whether reactive oxygen species production and resistance to oxidative stress might be causally involved in the exceptional longevity exhibited by the ocean quahog Arctica islandica. We tested this hypothesis by comparing reactive oxygen sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebb9b4a9fc469074e78fea0c69591c4a
https://doi.org/10.1093/gerona/glr044
https://doi.org/10.1093/gerona/glr044
Autor:
Carly S. Cox, Laura E. Newman, Gerald S. Shadel, Marissa A. Holmbeck, Andrew C. Scortea, Sharen E. McKay, Brooke E. Christian, Annie J. Tsay
Publikováno v:
Cell Metabolism. 28:776-786.e5
Transient mitochondrial stress can promote beneficial physiological responses and longevity, termed "mitohormesis." To interrogate mitohormetic pathways in mammals, we generated mice in which mitochondrial superoxide dismutase 2 (SOD2) can be knocked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e256e97699b788aebf086f8809dcdbf
https://doi.org/10.1016/j.cmet.2018.07.011
https://doi.org/10.1016/j.cmet.2018.07.011
Autor:
David M. Rand, Marissa A. Holmbeck
Fluctuations in temperature and resource availability are conditions many organisms contend with in nature. Specific dietary nutrients such as fatty acids play an essential role in reproduction, cold adaptation, and metabolism in a variety of organis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4fb7affe77df5837d2e0ca9cb82bfd0
https://europepmc.org/articles/PMC4612386/
https://europepmc.org/articles/PMC4612386/