The role of genetic polymorphisms in the thymidylate synthase (TYMS) gene in methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia

Autor: Sandra G. Heil, Marissa A. H. den Hoed, Marry M. van den Heuvel-Eibrink, Rob Pieters, Saskia M F Pluijm, Oliver Zolk, Marijn Berrevoets, Robert de Jonge, Susanne Hoerning, Natanja Oosterom, Wim J. E. Tissing

Publikováno v: PHARMACOGENETICS AND GENOMICS, 28(10), 223-229. LIPPINCOTT WILLIAMS & WILKINS
Oosterom, N, Berrevoets, M, den Hoed, M A H, Zolk, O, Hoerning, S, Pluijm, S M F, Pieters, R, de Jonge, R, Tissing, W J E, van den Heuvel-Eibrink, M M & Heil, S G 2018, ' The role of genetic polymorphisms in the thymidylate synthase (TYMS) gene in methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia ', Pharmacogenetics and Genomics, vol. 28, no. 10, pp. 223-229 . https://doi.org/10.1097/FPC.0000000000000352
Pharmacogenetics Genomics, 28(10), 223-229. Lippincott Williams & Wilkins
Pharmacogenetics and Genomics, 28(10), 223-229. Lippincott Williams and Wilkins Ltd.

Objective Methotrexate (MTX) is an important drug in the treatment of pediatric acute lymphoblastic leukemia (ALL). MTX is cytotoxic as it impairs DNA and RNA synthesis by inhibiting the enzymes dihydrofolate reductase (DHFR) and thymidylate synthase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b141985319efb6d42e25e6ed8252646d
https://hdl.handle.net/11370/c932a871-9240-4599-941c-107d13994681

Genetic variation and bone mineral density in long-term adult survivors of childhood cancer

Autor: Marry M. van den Heuvel-Eibrink, Saskia M F Pluijm, Marissa A. H. den Hoed, Rob Pieters, André G. Uitterlinden, Lisette Stolk

Publikováno v: Pediatric Blood & Cancer. 63:2212-2220

Purpose Despite similarities in upfront treatment of childhood cancer, not every adult survivor of childhood cancer (CCS) has an impaired bone mineral density (BMD). No data are available on the role of genetic variation on impairment of BMD in CCS.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28c467734195607c84ad92d0e29d3ec2
https://doi.org/10.1002/pbc.26198

Genetic Biomarkers to Identify the Risk of Osteonecrosis in Children with Acute Lymphoblastic Leukemia

Autor: Marry M. van den Heuvel-Eibrink, Saskia M F Pluijm, Rob Pieters, Marissa A. H. den Hoed, André G. Uitterlinden

Publikováno v: Molecular Diagnosis & Therapy, 20(6), 519-522. Adis

Osteonecrosis is a disabling complication of treatment for pediatric acute lymphoblastic leukemia, and much effort has been made to predict which patients are prone to develop this disease. Multiple clinical and genetic factors have already been iden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a38332b30d689ed2c362ecd71a55c897
https://pure.eur.nl/en/publications/402260a4-6602-4aa0-9632-c7636c9ad77f

Aggravated bone density decline following symptomatic osteonecrosis in children with acute lymphoblastic leukemia

Autor: Jan A. Leeuw, Rob Pieters, Marrie C. A. Bruin, Maarten H. Lequin, Mariël L. te Winkel, Hester A. de Groot-Kruseman, Inge M. van der Sluis, Jan C. Roos, Dorien Bresters, Marry M. van den Heuvel-Eibrink, Anjo J.P. Veerman, Saskia M F Pluijm, Marissa A. H. den Hoed, Peter M. Hoogerbrugge, Martha Fiocco

Publikováno v: Haematologica, 100(12), 1564-1570. Ferrata Storti Foundation
Pediatric Blood & Cancer, 62, S154-S154
den Hoed, M A H, Pluijm, S M F, te Winkel, M L, de Groot-Kruseman, H A, Fiocco, M, Hoogerbrugge, P, Leeuw, J A, de Bruin, M C A, van der Sluis, I M, Bresters, D, Lequin, M H, Roos, J C, Veerman, A J P, Pieters, R & van den Heuvel-Eibrink, M M 2015, ' Aggravated bone density decline following symptomatic osteonecrosis in children with acute lymphoblastic leukemia ', Haematologica, vol. 100, no. 12, pp. 1564-1570 . https://doi.org/10.3324/haematol.2015.125583
Haematologica, 100(12), 1564-1570
Haematologica
Haematologica, 100(12), 1564-1570. FERRATA STORTI FOUNDATION

Osteonecrosis and decline of bone density are serious side effects during and after treatment of childhood acute lymphoblastic leukemia. It is unknown whether osteonecrosis and low bone density occur together in the same patients, or whether these tw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3223080f238f7f2e9a5f8352cf2e32f4
https://pure.eur.nl/en/publications/ee5844ff-a00f-41aa-ae6b-c1a53c69e95a

CNOT1 Microrna Single Nucleotide Polymorphism (SNP) Determines the Occurrence of Methotrexate Related Mucositis in Pediatric Acute Lymphoblastic Leukemia

Autor: Marissa A. H. den Hoed, Wim J. E. Tissing, Saskia M F Pluijm, Rob Pieters, Robert de Jonge, Ángela Guttiérez-Camino, Natanja Oosterom, Sandra G. Heil, Elixabet Lopez-Lopez, Marry M. van den Heuvel-Eibrink, Africa Garcia-Orad

Publikováno v: Blood. 126:1237-1237

BACKGROUND Cure rates of pediatric acute lymphoblastic leukemia (ALL) have reached 90% in the developed countries. However, toxicity due to chemotherapeutic regimens occurs frequently but with great heterogeneity. This suggests that genetic variation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a673f2351557f0d8a8581168ab0dcb8d
https://doi.org/10.1182/blood.v126.23.1237.1237