Broadly directed SARS-CoV-2-specific CD4+ T cell response includes frequently detected peptide specificities within the membrane and nucleoprotein in patients with acute and resolved COVID-19.

Autor: Janna Heide, Sophia Schulte, Matin Kohsar, Thomas Theo Brehm, Marissa Herrmann, Hendrik Karsten, Matthias Marget, Sven Peine, Alexandra M Johansson, Alessandro Sette, Marc Lütgehetmann, William W Kwok, John Sidney, Julian Schulze Zur Wiesch

Publikováno v: PLoS Pathogens, Vol 17, Iss 9, p e1009842 (2021)

The aim of this study was to define the breadth and specificity of dominant SARS-CoV-2-specific T cell epitopes using a comprehensive set of 135 overlapping 15-mer peptides covering the SARS-CoV-2 envelope (E), membrane (M) and nucleoprotein (N) in a

Externí odkaz: https://doaj.org/article/3b58acfa22d6457a9bede62c52515988

Correction: Broadly directed SARS-CoV-2-specific CD4+ T cell response includes frequently detected peptide specificities within the membrane and nucleoprotein in patients with acute and resolved COVID-19

Autor: Sven Peine, Marissa Herrmann, Hendrik Karsten, Marc Lütgehetmann, Matthias Marget, Matin Kohsar, William W. Kwok, John Sidney, Janna Heide, Sophia Schulte, Alessandro Sette, Julian Schulze zur Wiesch, Alexandra M. Johansson, Thomas Theo Brehm

Publikováno v: PLoS Pathogens, Vol 18, Iss 1 (2022)
PLoS Pathogens, Vol 17, Iss 9, p e1009842 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 18, Iss 1, p e1010220 (2022)

The aim of this study was to define the breadth and specificity of dominant SARS-CoV-2-specific T cell epitopes using a comprehensive set of 135 overlapping 15-mer peptides covering the SARS-CoV-2 envelope (E), membrane (M) and nucleoprotein (N) in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dfc65ae5ea80fdabf70276d401d9bcb
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730411/?tool=EBI

Clonal expansion and activation of tissue-resident memory-like T H 17 cells expressing GM-CSF in the lungs of patients with severe COVID-19

Autor: Francesco Siracusa, Ansgar W. Lohse, Dominik Kylies, Filippo Cortesi, Yu Zhao, Mascha Binder, Nicola Gagliani, Susanne Pfefferle, Milagros N. Wong, Victor G. Puelles, Marissa Herrmann, Lidia Bosurgi, Christoph Schultheiß, Leon U. B. Enk, Patricia Bartsch, Stefan Bonn, Malte Hellmig, Ulf Panzer, Kevin Roedl, Dominik Jarczak, Elisa Rosati, Samuel Huber, Petra Bacher, Jan-Eric Turner, Christoph Kilian, Christian Krebs, Jan-Peter Sperhake, Ann-Christin Gnirck, Marc Lütgehetmann, Julian Schulze Zur-Wiesch, Stefan Steurer, Alina Borchers, Nicola Scheibel, Stefan Kluge, Marylyn M. Addo, Hans-Joachim Paust, Tobias B. Huber, Fabian Hausmann

Publikováno v: Science Immunology. 6

Hyperinflammation contributes to lung injury and subsequent acute respiratory distress syndrome (ARDS) with high mortality in patients with severe coronavirus disease 2019 (COVID-19). To understand the underlying mechanisms involved in lung pathology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed4a5ccddc6a55c72f86683a58fce8cc
https://doi.org/10.1126/sciimmunol.abf6692

Deciphering the Plasmodium falciparum malaria-specific CD4+ T-cell response: ex vivo detection of high frequencies of PD-1+TIGIT+ EXP1-specific CD4+ T cells using a novel HLA-DR11-restricted MHC class II tetramer.

Autor: Schulte, Sophia¹ (AUTHOR), Heide, Janna^1,2 (AUTHOR), Ackermann, Christin¹ (AUTHOR), Peine, Sven³ (AUTHOR), Ramharter, Michael^1,2,4 (AUTHOR), Mackroth, Maria Sophia^1,2,4,5 (AUTHOR), Woost, Robin^1,2 (AUTHOR), Jacobs, Thomas^2,5 (AUTHOR), Schulze zur Wiesch, Julian^1,2 (AUTHOR) j.schulze-zur-wiesch@uke.de

Publikováno v: Clinical & Experimental Immunology. Feb2022, Vol. 207 Issue 2, p227-236. 10p.

Real-world Effectiveness of Glecaprevir/Pibrentasvir (GLE/PIB) for Chronic Hepatitis C Infection: Evidence From a German Single-center Cohort Study.

Autor: Beisel, Claudia^1,2 c.beisel@uke.de, Herrmann, Marissa¹, Piecha, Felix^1,2, Lampalzer, Sibylle¹, Buescher, Gustav¹, Sven Pischke, S.^1,2, Schulze Zur Wiesch, Julian^1,2

Publikováno v: Hepatitis Monthly. Jan2021, Vol. 21 Issue 1, p1-6. 6p.