Výsledky vyhledávání - "Marisol Escriche"

Pharmacokinetics of multiple doses of co-crystal of tramadol-celecoxib: findings from a four-way randomized open-label phase I clinical trial

Autor: Artur Sans, Neus Gascón, Gregorio Encina, Eric Sicard, Lluis Soler, Carlos Plata-Salamán, Mariano Sust, Anna Vaqué, Mounia Lahjou, Sebastián Videla, Marisol Escriche

Publikováno v: British Journal of Clinical Pharmacology. 84:64-78

SummaryAim We compared the pharmacokinetic (PK) profiles of Co-Crystal of Tramadol-Celecoxib (CTC) versus each reference product (alone and in open combination) after single (first dose) and multiple dosing. Methods Healthy adults aged 18–50 years

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a98e87ff0e992972a035175df3adff9
https://doi.org/10.1111/bcp.13428

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The Effect of Food on Tramadol and Celecoxib Bioavailability Following Oral Administration of Co-Crystal of Tramadol-Celecoxib (CTC): A Randomised, Open-Label, Single-Dose, Crossover Study in Healthy Volunteers

Autor: Eric Sicard, Neus Gascón, Mounia Lahjou, Marisol Escriche, SebastiÃ¡n Videla, Mercedes Encabo, Carlos Plata-SalamÃ¡n, Gregorio Encina, Kevin Smith

Publikováno v: Clinical Drug Investigation
Dipòsit Digital de la UB
Universidad de Barcelona

Background and Objective Co-Crystal of Tramadol–Celecoxib (CTC), in development for the treatment of moderate to severe acute pain, is a first-in-class co-crystal containing a 1:1 molecular ratio of two active pharmaceutical ingredients; rac-tramad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5068330031369fa054a6198dab3bf50
https://pubmed.ncbi.nlm.nih.gov/30008052

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Pharmacokinetics of Tramadol and Celecoxib in Japanese and Caucasian Subjects Following Administration of Co-Crystal of Tramadol-Celecoxib (CTC): A Randomised, Open-Label Study

Autor: Carla Bennett, Marisol Escriche, Sabine Mersmann, Kevin John Smith, Gregorio Encina, Mercedes Encabo, Helen Dooner, Gill Mundin, Ulrike Lorch

Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics

Background and Objectives Co-Crystal of Tramadol-Celecoxib (CTC) is a first-in-class active pharmaceutical ingredient (API–API) co-crystal of rac-tramadol.HCl and celecoxib in a 1:1 molecular ratio (100 mg CTC: 44 mg rac-tramadol.HCl and 56 mg cele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac6a4c58dcaa816b68288e235e3bdc3
https://pubmed.ncbi.nlm.nih.gov/29956215

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Safety, tolerability and pharmacokinetics of single and multiple doses of a novel sigma-1 receptor antagonist in three randomized phase I studies

Autor: Gregorio Encina, Marisol Escriche, Mariano Sust, Anna Vaqué, Montserrat Abadías

Publikováno v: British Journal of Clinical Pharmacology. 75:103-117

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • A novel and highly selective sigma-1 receptor antagonist (S1RA) provides a new approach for pain management. S1RA has shown activity in animal models of neuropathic pain and potentiation of opioid analgesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ad48bc5cf98ed0d15b49eac85f627c6
https://doi.org/10.1111/j.1365-2125.2012.04333.x

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The Heat Shock Cognate Protein hsc73 Assembles with A1 Adenosine Receptors To Form Functional Modules in the Cell Membrane

Autor: Marisol Escriche, Rafael Franco, Sara Sarrió, Vicent Casadó, Enric I. Canela, Francisco Ciruela, Josefa Mallol, Carmen Lluis

Publikováno v: Molecular and Cellular Biology. 20:5164-5174

The ubiquitous nucleoside adenosine exerts multiple physiological actions via specific receptors, four of which (A1, A2a, A2b, and A3) have been cloned (see reference 25 for a review). Activation of A1 adenosine receptors (A1Rs) by adenosine or synth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a2f3833cd696e2959fe5baf46c3faf
https://doi.org/10.1128/mcb.20.14.5164-5174.2000

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A medicinal-chemistry-guided approach to selective and druglike sigma 1 ligands

Publikováno v: ChemMedChem. 1(1)

Based on a medicinal-chemistry-guided approach, three novel series of druglike cycloalkyl-annelated pyrazoles were synthesized and display high affinity (pKi>8) for the sigma1 receptor. Structure-affinity relationships were established, and the diffe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f200a1ba8122a9a10004c1b83f3077ec
https://pubmed.ncbi.nlm.nih.gov/16892345

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Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling

Autor: Josefa Mallol, Carmen Lluis, Marisol Escriche, Francisco Ciruela, Javier Burgueño, Carlos Enrich, Enric I. Canela, Rafael Franco

Publikováno v: Experimental cell research. 285(1)

The involvement of caveolae in the internalization of A 1 adenosine receptors (A 1 R) and the receptor sorting and recycling was studied in the smooth muscle cell line DDT 1 MF-2, by binding assays, by confocal microscopy, and at the structural level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12cd181eb821b1e6bd7e8bfb4b1d83af
https://pubmed.ncbi.nlm.nih.gov/12681288

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Metabotropic glutamate 1alpha and adenosine A1 receptors assemble into functionally interacting complexes

Autor: Rafael Franco, Javier Burgueño, Francisco Ciruela, Wai-Yee Chan, Marisol Escriche, R. A. Jeffrey McIlhinney, Josefa Mallol, Vicent Casadó, Mikhail Soloviev, Carmen Lluis, Enric I. Canela, Ester Angulo

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
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Dipòsit Digital de la UB
Universidad de Barcelona

Recently, evidence has emerged that seven transmembrane G protein-coupled receptors may be present as homo- and heteromers in the plasma membrane. Here we describe a new molecular and functional interaction between two functionally unrelated types of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4e8071c1a59565515a3374d3fb3f99
https://pubmed.ncbi.nlm.nih.gov/11278325

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Adenosine A(1) receptor in cultured neurons from rat cerebral cortex: colocalization with adenosine deaminase

Autor: Maria Ruiz, Antonio Andrés, Carmen Lluis, Mairena Martín, Rafael Franco, Manuel Ros, Marisol Escriche

Publikováno v: Journal of neurochemistry. 75(2)

Adenosine A(1) receptors (A(1)Rs) have been characterized in primary cultures of neurons from cerebral cortex. The specific adenosine A(1) antagonist 8-cyclopentyl-1,3-[(3)H]dipropylxanthine bound to both membranes and intact cells. When saturation e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2939f4335e19803f3379ae55b1d944ad
https://pubmed.ncbi.nlm.nih.gov/10899940

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