Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Marisol Cisternas"'
Autor:
Denisse Sepúlveda, Felipe Grunenwald, Alvaro Vidal, Paulina Troncoso-Escudero, Marisol Cisternas-Olmedo, Roque Villagra, Pedro Vergara, Carlos Aguilera, Melissa Nassif, Rene L. Vidal
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Insulin-like growth factor 2 (IGF2) and autophagy-related genes have been proposed as biomolecules of interest related to idiopathic Parkinson’s disease (PD). The objective of this study was to determine the IGF2 and IGF1 levels in plasma
Externí odkaz:
https://doaj.org/article/94b8c6f1859e461084e81569e52e168b
Autor:
Rodrigo Pérez-Arancibia, Marisol Cisternas-Olmedo, Denisse Sepúlveda, Paulina Troncoso-Escudero, Rene L. Vidal
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2023)
Neurological motor disorders (NMDs) such as Parkinson's disease and Huntington's disease are characterized by the accumulation and aggregation of misfolded proteins that trigger cell death of specific neuronal populations in the central nervous syste
Externí odkaz:
https://doaj.org/article/dafe83f4483d42ddbd245c1a6c1dc9de
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Parkinson’s disease (PD) is caused by the degeneration of dopaminergic neurons due to an accumulation of intraneuronal abnormal alpha-synuclein (α-syn) protein aggregates. It has been reported that the levels of exosomal α-syn of neuronal origin
Externí odkaz:
https://doaj.org/article/ade956d219374b4fbaa3c4d8f20d7362
Autor:
Luis F. González, Francisca Henríquez-Belmar, Claudia Delgado-Acevedo, Marisol Cisternas-Olmedo, Gloria Arriagada, Ramón Sotomayor-Zárate, Dennis L. Murphy, Pablo R. Moya
Publikováno v:
Biological Research, Vol 50, Iss 1, Pp 1-9 (2017)
Abstract Background Obsessive–compulsive disorder (OCD) is a severe neuropsychiatric condition affecting 1–3% of the worldwide population. OCD has a strong genetic component, and the SLC1A1 gene that encodes neuronal glutamate transporter EAAT3 i
Externí odkaz:
https://doaj.org/article/018f77851ef04a269b1903f900fac86d
Autor:
Sandra Arancibia-Opazo, J. Sebastián Contreras-Riquelme, Mario Sánchez, Marisol Cisternas-Olmedo, René L. Vidal, Alberto J. M. Martin, Mauricio A. Sáez
Huntington’s disease (HD) is a disorder caused by an abnormal expansion of trinucleotide CAG repeats within the huntingtin (Htt) gene. Under normal conditions, the CREB Binding Protein interacts with CREB elements and acetylates Lysine 27 of Histon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccad5f5e0243fdc7851bf9ea82806b7a
https://doi.org/10.1101/2023.01.19.524732
https://doi.org/10.1101/2023.01.19.524732
Autor:
Paulina Troncoso-Escudero, R. Luke Wiseman, Veronica Latapiat, Constanza Gonzalez, Paula Garcia-Huerta, José Cánovas, Julia M. D. Grandjean, Rene L. Vidal, Lars Plate, S. Pablo Sardi, Alexis Martinez, Marisol Cisternas, Hilal A. Lashuel, Valentina Castillo, Claudia A Rivera, Soledad Matus, Denisse Sepulveda, Carolina Jerez, Sirley Leal, Alberto J. M. Martin, Donzelli Sonia, Claudio Hetz
Publikováno v:
Mol Ther
Alteration to endoplasmic reticulum (ER) proteostasis is observed in a variety of neurodegenerative diseases associated with abnormal protein aggregation. Activation of the unfolded protein response (UPR) enables an adaptive reaction to recover ER pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd0b8b8da6617c6b3e24e314098c6a3
https://doi.org/10.1016/j.ymthe.2021.01.033
https://doi.org/10.1016/j.ymthe.2021.01.033
Autor:
Denisse Sepulveda, Alvaro Vidal, Felipe Grünenwald, Paulina Troncoso-Escudero, Marisol Cisternas-Olmedo, Roque Villagra, Pedro Vergara, Carlos Aguilera, Melissa Nassif, Rene L. Vidal
Insulin-like growth factor 2 (IGF2) and autophagy-related genes have been proposed as interesting biomolecules related to idiopathic Parkinson’s disease (PD). The objective of this study was to determine the IGF2 and IGF1 levels in plasma and perip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34ec66d2c192131dbf24408993681fb0
https://doi.org/10.21203/rs.3.rs-1072446/v1
https://doi.org/10.21203/rs.3.rs-1072446/v1
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Parkinson’s disease (PD) is caused by the degeneration of dopaminergic neurons due to an accumulation of intraneuronal abnormal alpha-synuclein (α-syn) protein aggregates. It has been reported that the levels of exosomal α-syn of neuronal origin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5beeb20f8e683b0fb11f74eda66b5ad9
https://pubmed.ncbi.nlm.nih.gov/35250476
https://pubmed.ncbi.nlm.nih.gov/35250476
Autor:
Alexis Martinez, Constanza Gonzalez, Paula Garcia-Huerta, Claudio Hetz, Rene L. Vidal, Carolina Jerez, Paulina Troncoso-Escudero, Marisol Cisternas, Denisse Sepulveda, Lars Plate, Sardi Sp, Castillo, Claudia A Rivera, Alberto J. M. Martin, R.L. Wiseman, Julia M. D. Grandjean, José Cánovas, Leal S, Matus S, Hilal A. Lashuel, Latapiat
Alteration to endoplasmic reticulum (ER) proteostasis is observed on a variety of neurodegenerative diseases associated with abnormal protein aggregation. Activation of the unfolded protein response (UPR) enables an adaptive reaction to recover ER pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9eda50b39bb5257d72dbf16c5a663ef4
https://doi.org/10.1101/2020.11.17.387480
https://doi.org/10.1101/2020.11.17.387480
Autor:
Carlos Spichiger, Steven Bergink, R. Luke Wiseman, Paulina Troncoso-Escudero, Neeraj Sharma, S. Pablo Sardi, Rene L. Vidal, Cristian Saquel, Pedro Chana-Cuevas, Lars Plate, Kizito Tshitoko Tshilenge, Paula Garcia-Huerta, Daniel R. Henríquez, Swati Naphade, Arun Thiruvalluvan, Hans Richter, Lisa M. Ellerby, Brad J. Geddes, Claudio Hetz, Marisol Cisternas-Olmedo, Gerardo Z. Lederkremer, Marina Shenkman, Felipe A. Court, Peter Thielen, Kenneth A. Longo, Christian Gonzalez-Billault, Di Wu
Publikováno v:
Acta Neuropathologica, 140(5), 737-764. SPRINGER
Acta Neuropathol
Acta Neuropathol
Impaired neuronal proteostasis is a salient feature of many neurodegenerative diseases, highlighting alterations in the function of the endoplasmic reticulum (ER). We previously reported that targeting the transcription factor XBP1, a key mediator of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25da26bb87d79b3b9b7508264344ca44
https://research.rug.nl/en/publications/15f5fa78-12a6-49c9-8d0c-be943c0ed201
https://research.rug.nl/en/publications/15f5fa78-12a6-49c9-8d0c-be943c0ed201