Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Mariska, Klepper"'
Autor:
Nicolle H. R. Litjens, Amy C. J. van der List, Mariska Klepper, Derek Reijerkerk, Fréderique Prevoo, Michiel G. H. Betjes
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionOlder recipient age is associated with a significant decreased risk for rejection after kidney transplantation which is incompletely understood.MethodsIn a longitudinal study, circulating alloreactive T cells were assessed of young (≤45
Externí odkaz:
https://doaj.org/article/c6dee10092a64cacb8727de6e9c2b4ae
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Natural killer (NK) cells express the Fc-gamma receptor CD16 (FCGR3A) and could therefore mediate renal endothelial cell damage in cases of chronic-active antibody mediated rejection (c-aABMR). The V/V-genotype of the FCGR3A 158 F/V polymorp
Externí odkaz:
https://doaj.org/article/88ea22a438af467185d0b24ff6683a60
Publikováno v:
Immunity & Ageing, Vol 17, Iss 1, Pp 1-10 (2020)
Abstract Background End-stage renal disease is associated with premature ageing of the T cell immune system but inter-individual variation is substantial. The hypothesis was tested that advanced immunological T cell ageing assessed by peripheral T ce
Externí odkaz:
https://doaj.org/article/7f61df2ef1354b6caecacb090065bcb1
Autor:
Leontine H. Wijngaarden, Erwin van der Harst, René A. Klaassen, Martin Dunkelgrun, T Martijn Kuijper, Mariska Klepper, Gisela Ambagtsheer, Jan N. M. IJzermans, Ron W. F. de Bruin, Nicolle H. R. Litjens
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Morbid obesity is characterized by chronic, low-grade inflammation, which is associated with ‘inflamm-aging’. The presence of metabolic syndrome (MetS) might accelerate this phenomenon of metaflammation. In this study, we assessed the effects of
Externí odkaz:
https://doaj.org/article/088d317e9d6c490d8459ba09dd907fcd
Autor:
Michiel G. H. Betjes, Frederique Prevoo, Thierry P. P. van den Bosch, Mariska Klepper, Nicolle H. R. Litjens
Publikováno v:
Cells, Vol 11, Iss 14, p 2233 (2022)
Studying functionality and antigen-specificity of resident kidney T cells derived from a kidney biopsy is hampered by the lack of sufficient numbers of T cells obtained by the standard method of enzymatic tissue dissociation. Enzymatic dissociation o
Externí odkaz:
https://doaj.org/article/ebc6d6fe87124017bab47bf3391416af
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Development of T-cell hyporesponsiveness to donor antigen may explain the substantial decreased risk for acute rejection in the years following kidney transplantation. The underlying mechanisms of donor-specific hyporesponsiveness (DSH) are largely u
Externí odkaz:
https://doaj.org/article/8fc6e18b36f74403af21ede536977391
Autor:
Nicolle H. R. Litjens, Anton W. Langerak, Amy C. J. van der List, Mariska Klepper, Maaike de Bie, Zakia Azmani, Alexander T. den Dekker, Rutger W. W. Brouwer, Michiel G. H. Betjes, Wilfred F. J. Van IJcken
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Transcriptomics can be combined with TRA and TRB clonotype analysis at the single cell level. The aim of this study was to validate this approach on the ICELL8 Single-Cell system and to evaluate its usefulness to analyse clinical paucicellular sample
Externí odkaz:
https://doaj.org/article/306135e5e78044de8362b0971dd85cf5
pERK-dependent defective TCR-mediated activation of CD4+ T cells in end-stage renal disease patients
Autor:
Ling Huang, Nicolle H. R. Litjens, Nynke M. Kannegieter, Mariska Klepper, Carla C. Baan, Michiel G. H. Betjes
Publikováno v:
Immunity & Ageing, Vol 14, Iss 1, Pp 1-14 (2017)
Abstract Background Patients with end-stage renal disease (ESRD) have an impaired immune response with a prematurely aged T-cell system. Mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase (ERK) and p38, regulate
Externí odkaz:
https://doaj.org/article/7060b6c5185b4bfe94a978062f620a57
Autor:
Nicole M. van Besouw, Lin Yan, Ronella de Kuiper, Mariska Klepper, Derek Reijerkerk, Marjolein Dieterich, Dave L. Roelen, Frans H. J. Claas, Marian C. Clahsen-van Groningen, Dennis A. Hesselink, Carla C. Baan
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Interleukin (IL)-21 supports induction and expansion of CD8+ T cells, and can also regulate the differentiation of B cells into antibody-producing plasma cells. We questioned whether the number of circulating donor-specific IL-21 producing cells (pc)
Externí odkaz:
https://doaj.org/article/9bd62742a4c3421bb4294b61a8376a64
Autor:
Nicolle H R Litjens, Amy C J van der List, Mariska Klepper, Fréderique Prevoo, Karin Boer, Dennis A Hesselink, Michiel G H Betjes
Publikováno v:
Clinical and Experimental Immunology.
Acute T-cell-mediated rejection (aTCMR) still remains a clinical problem after kidney transplantation despite significant improvements in immunosuppressive regimens. Polyfunctional T cells, i.e. T cells producing multiple pro-inflammatory cytokines,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2968e8ec84283c7b67d4042d97f005f5
https://doi.org/10.1093/cei/uxad041
https://doi.org/10.1093/cei/uxad041