Zobrazeno 1 - 10
of 224
pro vyhledávání: '"Marisa S, Bartolomei"'
Autor:
Yee Hoon Foong, Blake Caldwell, Joanne L. Thorvaldsen, Christopher Krapp, Clementina A. Mesaros, Wanding Zhou, Rahul M. Kohli, Marisa S. Bartolomei
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
TET1/2/3 dioxygenases iteratively demethylate 5-methylcytosine, beginning with the formation of 5-hydroxymethylcytosine (5hmC). The post-mitotic brain maintains higher levels of 5hmC than most peripheral tissues, and TET1 ablation studies have unders
Externí odkaz:
https://doaj.org/article/15da1f095f5e460fb87e5885ecd73cc9
Autor:
Suhee Chang, Stella K. Hur, Natali S. Sobel Naveh, Joanne L. Thorvaldsen, Deborah L. French, Alyssa L Gagne, Chintan D. Jobaliya, Montserrat C. Anguera, Marisa S. Bartolomei, Jennifer M Kalish
Publikováno v:
Epigenetics, Vol 16, Iss 12, Pp 1295-1305 (2021)
Genomic imprinting is a rare form of gene expression in mammals in which a small number of genes are expressed in a parent-of-origin-specific manner. The aetiology of human imprinting disorders is diverse and includes chromosomal abnormalities, mutat
Externí odkaz:
https://doaj.org/article/03d418f378ec4d8dbddcd0b45ec27f03
Autor:
Suhee Chang, Diana Fulmer, Stella K Hur, Joanne L Thorvaldsen, Li Li, Yemin Lan, Eric A Rhon-Calderon, Nicolae Adrian Leu, Xiaowen Chen, Jonathan A Epstein, Marisa S Bartolomei
Publikováno v:
eLife, Vol 11 (2022)
Dysregulation of the imprinted H19/IGF2 locus can lead to Silver-Russell syndrome (SRS) in humans. However, the mechanism of how abnormal H19/IGF2 expression contributes to various SRS phenotypes remains unclear, largely due to incomplete understandi
Externí odkaz:
https://doaj.org/article/6e1ce1ff28534687a37e77cf4367e911
Autor:
Lisa A. Vrooman, Eric A. Rhon-Calderon, Kashviya V. Suri, Asha K. Dahiya, Yemin Lan, Richard M. Schultz, Marisa S. Bartolomei
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Assisted Reproductive Technologies (ART) employ gamete/embryo handling and culture in vitro to produce offspring. ART pregnancies have an increased risk of low birth weight, abnormal placentation, pregnancy complications, and imprinting disorders. Em
Externí odkaz:
https://doaj.org/article/405f514faa63424991e2178a37e8e6d0
Publikováno v:
PLoS Genetics, Vol 16, Iss 8, p e1008970 (2020)
Externí odkaz:
https://doaj.org/article/df1f00b466f0486ab95e4a21f5ce7b97
Modeling human epigenetic disorders in mice: Beckwith-Wiedemann syndrome and Silver-Russell syndrome
Autor:
Suhee Chang, Marisa S. Bartolomei
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 5 (2020)
Genomic imprinting, a phenomenon in which the two parental alleles are regulated differently, is observed in mammals, marsupials and a few other species, including seed-bearing plants. Dysregulation of genomic imprinting can cause developmental disor
Externí odkaz:
https://doaj.org/article/0a56dd9710b04361a0dad05fd6b829d8
Autor:
Huijuan Lin, Keren Cheng, Hiroshi Kubota, Yemin Lan, Simone S. Riedel, Kazue Kakiuchi, Kotaro Sasaki, Kathrin M. Bernt, Marisa S. Bartolomei, Mengcheng Luo, P. Jeremy Wang
Publikováno v:
Genes & Development. 36:752-763
Self-renewal of spermatogonial stem cells is vital to lifelong production of male gametes and thus fertility. However, the underlying mechanisms remain enigmatic. Here, we show that DOT1L, the sole H3K79 methyltransferase, is required for spermatogon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acf4047ecfb6cac805323a46b6d08c85
https://doi.org/10.1101/gad.349550.122
https://doi.org/10.1101/gad.349550.122
Autor:
Mark Vander Roest, Christopher Krapp, Joanne L. Thorvaldsen, Marisa S. Bartolomei, W. David Merryman
Publikováno v:
Physiological Reports, Vol 7, Iss 19, Pp n/a-n/a (2019)
Abstract Epigenetic dysregulation of long noncoding RNA H19 was recently found to be associated with calcific aortic valve disease (CAVD) in humans by repressing NOTCH1 transcription. This finding offers a possible epigenetic explanation for the abun
Externí odkaz:
https://doaj.org/article/bb3ffdafb7cc4086883fc9a0c886ea07
Autor:
Orsolya Symmons, Marcello Chang, Ian A Mellis, Jennifer M Kalish, Jihwan Park, Katalin Suszták, Marisa S Bartolomei, Arjun Raj
Publikováno v:
PLoS Genetics, Vol 15, Iss 1, p e1007874 (2019)
Extensive cell-to-cell variation exists even among putatively identical cells, and there is great interest in understanding how the properties of transcription relate to this heterogeneity. Differential expression from the two gene copies in diploid
Externí odkaz:
https://doaj.org/article/27f0229be3ce4bfeaa5abe3e5f6b5b15
Autor:
Rexxi D. Prasasya, Blake A. Caldwell, Zhengfeng Liu, Songze Wu, Nicolae A. Leu, Johanna M. Fowler, Steven A. Cincotta, Diana J. Laird, Rahul M. Kohli, Marisa S. Bartolomei
Publikováno v:
bioRxiv
SUMMARYDNA methylation erasure is required for mammalian primordial germ cell reprogramming. TET enzymes iteratively oxidize 5-methylcytosine to generate 5-hyroxymethylcytosine (5hmC), 5-formylcytosine, and 5-carboxycytosine to facilitate active geno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c22830e54fa668773722c188989ef1e3
https://europepmc.org/articles/PMC9980038/
https://europepmc.org/articles/PMC9980038/
