Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Marisa K Kilgour"'
Autor:
Peyman Ghorbani, Sang Yong Kim, Tyler K T Smith, Lucía Minarrieta, Victoria Robert-Gostlin, Marisa K Kilgour, Maja Ilijevska, Irina Alecu, Shayne A Snider, Kaitlyn D Margison, Julia R C Nunes, Daniel Woo, Ciara Pember, Conor O'Dwyer, Julie Ouellette, Pavel Kotchetkov, Julie St-Pierre, Steffany A L Bennett, Baptiste Lacoste, Alexandre Blais, Meera G Nair, Morgan D Fullerton
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011658 (2023)
Type 2 cytokines like IL-4 are hallmarks of helminth infection and activate macrophages to limit immunopathology and mediate helminth clearance. In addition to cytokines, nutrients and metabolites critically influence macrophage polarization. Choline
Externí odkaz:
https://doaj.org/article/90d98c83331e4ab19bdf970a30da6155
Autor:
Sarah MacPherson, Sarah Keyes, Marisa K. Kilgour, Julian Smazynski, Vanessa Chan, Jessica Sudderth, Tim Turcotte, Adria Devlieger, Jessie Yu, Kimberly S. Huggler, Jason R. Cantor, Ralph J. DeBerardinis, Christopher Siatskas, Julian J. Lum
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 380-393 (2022)
Ex vivo expansion conditions used to generate T cells for immunotherapy are thought to adopt metabolic phenotypes that impede therapeutic efficacy in vivo. The comparison of five different culture media used for clinical T cell expansion revealed uni
Externí odkaz:
https://doaj.org/article/f33f2e28b0854ba7b43b89b360c06564
Autor:
Marisa K. Kilgour, Sarah MacPherson, Lauren G. Zacharias, Jodi LeBlanc, Sindy Babinszky, Gabrielle Kowalchuk, Scott Parks, Ryan D. Sheldon, Russell G. Jones, Ralph J. DeBerardinis, Phineas T. Hamilton, Peter H. Watson, Julian J. Lum
Publikováno v:
Nature Protocols. 17:2668-2698
Autor:
Julia R.C. Nunes, Tyler K.T. Smith, Peyman Ghorbani, Conor O'Dwyer, Natasha A. Trzaskalski, Habiba Dergham, Ciara Pember, Marisa K. Kilgour, Erin E. Mulvihill, Morgan D. Fullerton
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism.
Metabolic dysfunction-associated fatty liver disease (MAFLD) represents a growing cause of mortality and morbidity and encompasses a spectrum of liver pathologies. While dozens of preclinical models have been developed to recapitulate stages of MAFLD
Autor:
Marisa K. Kilgour, Donald J. Bastin, Seung-Hwan Lee, Michele Ardolino, Scott McComb, Alissa Visram
Publikováno v:
Frontiers in Immunology. 14
Advancements in chimeric antigen receptor engineered T-cell (CAR-T) therapy have revolutionized treatment for several cancer types over the past decade. Despite this success, obstacles including the high price tag, manufacturing complexity, and treat
Autor:
Julia R.C. Nunes, Tyler K.T. Smith, Peyman Ghorbani, Conor O’Dwyer, Natasha A. Trzaskalski, Habiba Dergham, Ciara Pember, Marisa K. Kilgour, Erin E. Mulvihill, Morgan D. Fullerton
ObjectiveMetabolic dysfunction-associated fatty liver disease (MAFLD) represents a growing cause of mortality and morbidity and encompasses a spectrum of liver pathologies. Potential therapeutic targets have been identified and are currently being pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97799496696775ed8d54eaf274a706c2
https://doi.org/10.1101/2023.01.24.524609
https://doi.org/10.1101/2023.01.24.524609
Autor:
Sarah McPhedran, Junu Choe, Sarah MacPherson, Gabrielle Kowalchuk, Vanessa Chan, Marisa K. Kilgour, Julian J. Lum
Publikováno v:
Methods in Molecular Biology ISBN: 9781071629130
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8f484eb6e1a07cdb93500ae45b8e64c
https://doi.org/10.1007/978-1-0716-2914-7_8
https://doi.org/10.1007/978-1-0716-2914-7_8
Autor:
Sarah, McPhedran, Junu, Choe, Sarah, MacPherson, Gabrielle, Kowalchuk, Vanessa, Chan, Marisa K, Kilgour, Julian J, Lum
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2614
One method of immune evasion that cancer cells employ is the secretion of immune regulatory metabolites into the tumor microenvironment (TME). These metabolites can promote immunosuppressive cell subsets, while inhibiting key tumor-killing subsets, s
Autor:
Peyman Ghorbani, Sang Yong Kim, Tyler K.T. Smith, Lucía Minarrieta, Marisa K. Kilgour, Maja Ilijevska, Irina Alecu, Shayne A. Snider, Kaitlyn D. Margison, Julia R.C. Nunes, Daniel Woo, Ciara Pember, Conor O’Dwyer, Julie St-Pierre, Steffany A.L. Bennett, Meera G. Nair, Morgan D. Fullerton
Choline is an essential nutrient and in macrophages, mainly supports phosphatidylcholine (PC) synthesis. Cellular uptake and incorporation of choline into PC is critical for LPS-induced macrophage inflammation. Here, we examined choline metabolism in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0764d0bfb3645b653937339ae6a24fd
https://doi.org/10.1101/2022.09.30.510305
https://doi.org/10.1101/2022.09.30.510305
Autor:
Marisa K, Kilgour, Sarah, MacPherson, Lauren G, Zacharias, Jodi, LeBlanc, Sindy, Babinszky, Gabrielle, Kowalchuk, Scott, Parks, Ryan D, Sheldon, Russell G, Jones, Ralph J, DeBerardinis, Phineas T, Hamilton, Peter H, Watson, Julian J, Lum
Publikováno v:
Nature protocols. 17(11)
Identifying metabolites and delineating their immune-regulatory contribution in the tumor microenvironment is an area of intense study. Interrogating metabolites and metabolic networks among immune cell subsets and host cells from resected tissues an