Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Marisa Carbonaro"'
Autor:
Marisa Carbonaro, Jeffrey Lee, Evangelos Pefanis, Mathieu Desclaux, Kehui Wang, Alexander Pennington, Hui Huang, Alejo Mujica, Jose Rojas, Roxanne Ally, Daniel Kennedy, Michael Brown, Vitaliy Rogulin, Sven Moller-Tank, Leah Sabin, Brian Zambrowicz, Gavin Thurston, Zhe Li
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Humanized liver rodent models, in which the host liver parenchyma is repopulated by human hepatocytes, have been increasingly used for drug development and disease research. Unlike the leading humanized liver mouse model in which Fumarylacet
Externí odkaz:
https://doaj.org/article/f36f9f2973d74161ab4380d6be2edfb7
Autor:
Marisa Carbonaro, Kehui Wang, Hui Huang, Davor Frleta, Aditi Patel, Alexander Pennington, Mathieu Desclaux, Sven Moller-Tank, Justin Grindley, Judith Altarejos, Jun Zhong, Greg Polites, William Poueymirou, Stephen Jaspers, Christos Kyratsous, Brian Zambrowicz, Andrew Murphy, John C. Lin, Lynn E. Macdonald, Christopher Daly, Mark Sleeman, Gavin Thurston, Zhe Li
Publikováno v:
Science Advances. 9
Liver steatosis is an increasing health issue with few therapeutic options, partly because of a paucity of experimental models. In humanized liver rodent models, abnormal lipid accumulation in transplanted human hepatocytes occurs spontaneously. Here
Autor:
Marisa Carbonaro, Ciro Bonetti, Hui Huang, Kehui Wang, Mathieu Desclaux, Guochun Gong, John C. Lin, Christopher Daly, Gavin Thurston, Zhe Li
Publikováno v:
Cancer Research. 83:35-35
The incidence of liver cancer is growing worldwide, and it is estimated that by 2025, over 1 million individuals will be affected by liver cancer every year. Hepatocellular carcinoma (HCC) accounts for about 90% of primary liver cancer cases and is o
Autor:
Jessica Harper Calderon, Yasalp Jimenez, Hock E, Zhe Li, Marisa Carbonaro, Kevin Barringer, Gavin Thurston, Courtney M. Williams, Christopher Daly, Maria del Pilar Molina-Portela
Publikováno v:
The FASEB Journal. 35
Human Fibroblast Growth Factor 19 (FGF19) and mouse ortholog Fgf15 play similar roles in liver regeneration and metabolism via the activation of Fgfr4/b-klotho (Klb). Monomeric FGF19 and dimeric Fgf15 are both necessary for liver regeneration and pro
Publikováno v:
Journal of Biological Chemistry. 287:11859-11869
Disruption of the microtubule cytoskeleton impairs tumor angiogenesis by inhibiting the hypoxia-inducible factor (HIF-1α) pathway. However, the signaling cascade linking microtubule disruption to HIF-1α inactivation has not been elucidated. Here, w
Autor:
Marisa Carbonaro, Hening Lin, Paraskevi Giannakakou, Ying-Ling Chiang, Bin He, Hui Jing, Yashira L Negrón Abril, Robert S. Weiss, Teresa L. Southard, Jack Stupinski, Jing Hu, Keren Weiser
Publikováno v:
Cancer Cell. 29:767-768
Targeting sirtuins for cancer treatment has been a topic of debate due to conflicting reports and lack of potent and specific inhibitors. We have developed a thiomyristoyl lysine compound, TM, as a potent SIRT2-specific inhibitor with a broad antican
Autor:
Naveed Akhtar, Eli L. Diamond, Paraskevi Giannakakou, Scott T. Tagawa, Marisa Carbonaro, Ana M. Molina, David M. Nanus
Publikováno v:
Critical reviews in oncology/hematology. 96(3)
Background Renal cell carcinoma (RCC) is a heterogeneous disease with regards to histology, progression, and response to treatment. Cytotoxic chemotherapy has been extensively studied in metastatic RCC (mRCC). Responses in most studies are modest and
Autor:
Marisa, Carbonaro, Daniel, Escuin, Aurora, O'Brate, Maria, Thadani-Mulero, Paraskevi, Giannakakou
Publikováno v:
The Journal of biological chemistry. 287(15)
Disruption of the microtubule cytoskeleton impairs tumor angiogenesis by inhibiting the hypoxia-inducible factor (HIF-1α) pathway. However, the signaling cascade linking microtubule disruption to HIF-1α inactivation has not been elucidated. Here, w
Publikováno v:
The Journal of Cell Biology
Active translation of HIF-1α requires association and trafficking of HIF mRNA on dynamic microtubules, whereas microtubule disruption represses HIF-1α translation by releasing its mRNA from polysomes and sequestering it to P-bodies.
The hypoxi
The hypoxi
Publikováno v:
Cancer Research. 73:2318-2318
Microtubule (MT)-targeting drugs, and in particular the MT-stabilizing drug Taxol, are the most widely used and most effective class of drugs in clinical oncology. However, certain tumor types are refractory to MT-based therapy, and even responsive t