Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Marisa Alcaide-German"'
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Abstract A1-59: Multiple mechanisms of MYCN dysregulation in Wilms tumor
Autor: Kathy Pritchard-Jones, John R. Apps, Marry M. van den Heuvel-Eibrink, Gordan M. Vujanic, Harm van Tinteren, David Gisselsson, Marcel Kool, Sergey Popov, Jenny Wegert, Marisa Alcaide-German, Manfred Gessler, Norbert Graf, Tasnim Chagtai, Richard D. Williams
Publikováno v: Cancer Research. 75:A1-59
Background and Purpose: Wilms tumor (WT) is the commonest pediatric renal malignancy. A significant minority of cases have mutations in known genes or recurrent copy number aberrations, but few of these have prognostic value. We have previously obser
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7f981759630e2c357a9d3facd540c6a
https://doi.org/10.1158/1538-7445.transcagen-a1-59
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2
Rad51 inhibition is an effective means of targeting DNA repair in glioma models and CD133+ tumor-derived cells
Autor: M Shaked-Rabi, Christine Martindale, Marisa Alcaide-German, S. Bourne, Ka Ian Lio, Susan C Short, M. Worku, George Sioftanos, Silvia Giampieri
Publikováno v: Neuro-Oncology. 13:487-499
High grade gliomas (HGGs) are characterized by resistance to radiotherapy and chemotherapy. Targeting Rad51-dependent homologous recombination repair may be an effective target for chemo- and radiosensitization. In this study we assessed the role of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc377707d98f3178551f51dc2117faf2
https://doi.org/10.1093/neuonc/nor010
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3
Comparative methylome analysis identifies new tumour subtypes and biomarkers for transformation of nephrogenic rests into Wilms tumour
Autor: Marisa Alcaide-German, Stephan Beck, Neil J. Sebire, Tasnim Chagtai, Jocelyn Charlton, Paul Guilhamon, Richard D. Williams, Kathy Pritchard-Jones, Tiffany Morris, Lee M. Butcher, Gordan M. Vujanic, Sergey Popov
Publikováno v: Genome Medicine
Background Wilms tumours (WTs) are characterised by several hallmarks that suggest epimutations such as aberrant DNA methylation are involved in tumour progression: loss of imprinting at 11p15, lack of recurrent mutations and formation of nephrogenic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295622f911bcc8c1f44e041c5ec5b082
http://europepmc.org/articles/PMC4354990
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4
Methylome analysis identifies a Wilms tumor epigenetic biomarker detectable in blood
Autor: Kathy Pritchard-Jones, Stephan Beck, Neil J. Sebire, Marisa Alcaide-German, Mark E. Weeks, Jocelyn Charlton, Lee M. Butcher, Sergey Popov, Gordan M. Vujanic, Richard D. Williams, William Mifsud
Publikováno v: Genome Biology
Background Wilms tumor is the most common pediatric renal malignancy and there is a clinical need for a molecular biomarker to assess treatment response and predict relapse. The known mutated genes in this tumor type show low mutation frequencies, wh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7c7a6b429866f3bded5e27679c406f
https://doi.org/10.1186/s13059-014-0434-y
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6
Abstract B36: DNA methylation profiling describes Wilms tumor evolution from its precursor lesion
Autor: Marisa Alcaide-German, Sergey Popov, Kathy Pritchard-Jones, Stephan Beck, Neil J. Sebire, Jocelyn Charlton, Richard D. Williams
Publikováno v: Cancer Research. 73:B36-B36
Wilms tumor (WT) is the most common pediatric renal cancer and represents a model of disruption in kidney development with observed lesions of undifferentiated embryonic kidney termed nephrogenic rests (NR) which are considered precursor lesions. Epi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00aa247dc6810c736d7f3b77aed6f220
https://doi.org/10.1158/1538-7445.cec13-b36
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7
Abstract 660: Genome Wide DNA methylation profiling in Wilms tumor. Integration with expression and identification of molecular signatures associated with high risk blastemal type histology
Autor: Tiffany Morris, Marisa Alcaide German, Jocelyn Charlton, Tasnim Chagtai, Kerra Pearce, Kathy Pritchard-Jones, Richard D. Williams
Publikováno v: Cancer Research. 73:660-660
Introduction: Wilms tumour (WT) is the most common paediatric renal tumour, thought to arise from disruption in normal kidney development. WT typically presents triphasic histology with blastemal, stromal and epithelial components. The International
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c43878f0cdbfa22494b5260e2f7c0368
https://doi.org/10.1158/1538-7445.am2013-660
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8
Multiple mechanisms of MYCN dysregulation in Wilms tumour
Autor: Gordan M. Vujanic, Marcel Kool, Norbert Graf, Richard D. Williams, Marisa Alcaide-German, Tasnim Chagtai, Manfred Gessler, Kathy Pritchard-Jones, John R. Apps, Sergey Popov, Harm van Tinteren, Jenny Wegert, Marry M. van den Heuvel-Eibrink, David Gisselsson, Jan de Kraker
Publikováno v: Scopus-Elsevier
Oncotarget; 6(9), pp 7232-7243 (2015)
Oncotarget, 6(9), 7232-7243. Impact Journals LLC
Europe PubMed Central
Oncotarget, 6(9), 7232-7243. Impact Journals
Oncotarget
Genomic gain of the proto-oncogene transcription factor gene MYCN is associated with poor prognosis in several childhood cancers. Here we present a comprehensive copy number analysis of MYCN in Wilms tumour (WT), demonstrating that gain of this gene
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04030093fbd9daf033c96257cda894a
http://www.scopus.com/inward/record.url?eid=2-s2.0-84924682507&partnerID=MN8TOARS
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