Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Marisa A. Brake"'
Publikováno v:
Seminars in Thrombosis and Hemostasis.
Tissue factor (TF) is the primary initiator of blood coagulation in humans. As improper intravascular TF expression and procoagulant activity underlie numerous thrombotic disorders, there has been longstanding interest in the contribution of heritabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9084804a48e2becbca8e33e986a652ea
https://doi.org/10.1055/s-0043-1769079
https://doi.org/10.1055/s-0043-1769079
Autor:
Linzi M Hobbs, Marisa A Brake, Adrianna Jurek, Lauren C Barbarich, Kelsey A Hobbs, Audrey C Cleuren, Roman N Rodionov, Randal J Westrick
Publikováno v:
Blood. 140:5534-5535
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f7265d9902c31ad73f596c64f15b837
https://doi.org/10.1182/blood-2022-170848
https://doi.org/10.1182/blood-2022-170848
Autor:
Tyler M. Parsons, Katie L. Buelow, Alaa Hanna, Marisa A. Brake, Crystal Poma, Sarah E. Hosch, Randal J. Westrick, Luis G. Villa-Diaz, George D. Wilson, Gerard J. Madlambayan
Publikováno v:
Br J Cancer
BACKGROUND: Bone-marrow-derived haematopoietic stem and progenitor cells (HSPCs) are a prominent part of the highly complex tumour microenvironment (TME) where they localise within tumours and maintain haematopoietic potency. Understanding the role H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c376d4cacd547df1859bcd99e0fdf4e5
https://pubmed.ncbi.nlm.nih.gov/34931040
https://pubmed.ncbi.nlm.nih.gov/34931040
Autor:
Martijn A. van der Ent, Randy J Westrick, Aaron Scholl, Audrey C. A. Cleuren, Dakota R Redshaw, Caitlin Schneider, Marisa A Brake, Adrianna Jurek
Publikováno v:
Blood. 138:442-442
Background: Factor V Leiden (FVL) is a common thrombosis susceptibility variant in humans. It is incompletely penetrant; this indicates that there are modifiers of FVL that alter thrombosis susceptibility. We used mouse models of FVL (F5L) and hetero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4385a3bf5578dd43b9ebccb5e2ae6987
https://doi.org/10.1182/blood-2021-153531
https://doi.org/10.1182/blood-2021-153531
Autor:
Sol Schulman, Emale El-Darzi, Kathelijne Peerlinck, Chad A. Cowan, Calvin R. Schuster, Marisa A Brake, Mary H.C. Florido, Robert Flaumenhaft, Ernest Turro, Max Friesen, Nihr BioResource, Kathleen Freson, Willem H. Ouwehand, Glenn Merrill-Skoloff, Bruce Furie, Randal J. Westrick, Lin Lin
Publikováno v:
J Clin Invest
Tissue factor (TF) is the primary initiator of blood coagulation in vivo and the only blood coagulation factor for which a human genetic defect has not been described. As there are no routine clinical assays that capture the contribution of endogenou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa836d3c1f116210052b3697b568d3a8
https://pubmed.ncbi.nlm.nih.gov/32663190
https://pubmed.ncbi.nlm.nih.gov/32663190
Autor:
Susan A. Maroney, Marisa A Brake, Randal J. Westrick, Nicolas D. Martinez, Lacramioara Ivanciu, Alan E. Mast
Publikováno v:
Curr Protoc Mouse Biol
The mammalian blood coagulation system was designed to restrict blood loss due to injury as well as keep the blood fluid within the blood vessels of the organism. Blood coagulation activity in inbred mouse strains varies widely among strains, suggest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::549ffdf43d3d2e6f7bc1c414194cc2d9
https://pubmed.ncbi.nlm.nih.gov/30875463
https://pubmed.ncbi.nlm.nih.gov/30875463
Autor:
Lauren C Barbarich, Kelsey A Hobbs, Randal J. Westrick, Dakota R Redshaw, Roman N. Rodionov, Marisa A Brake, Linzi M Hobbs
Publikováno v:
Blood. 136:4-4
Background: Pregnancy is a major risk factor for venous thromboembolism (VTE) and is the leading cause of maternal death during pregnancy and the immediate post-partum period. Although plasma levels of clotting factors and fibrinolysis inhibitors are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::924bfa9a1f6a90a67a3253e8deb09412
https://doi.org/10.1182/blood-2020-143243
https://doi.org/10.1182/blood-2020-143243
Autor:
Randal J. Westrick, Jishu Xu, Lena M Mishack, Jun Li, Alexander J Johnston, David Ginsburg, Emilee N. Kotnik, Mary E. Winn, Linzi M Hobbls, Audrey C. A. Cleuren, Sara L. Manning, Guojing Zhu, David R. Siemieniak, Sarah L. Dobies, Marisa A Brake, Amy E. Siebert, Kärt Tomberg, Thomas L. Saunders
Factor V Leiden (F5L ) is a common genetic risk factor for venous thromboembolism in humans. We conducted a sensitized N-ethyl-N-nitrosourea (ENU) mutagenesis screen for dominant thrombosuppressor genes based on perinatal lethal thrombosis in mice ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f578ce95856824577221a23488cc806
https://europepmc.org/articles/PMC5594664/
https://europepmc.org/articles/PMC5594664/
Autor:
Amy E Siebert, Stephanie C Verbeek, Alexander J Johnston, Marisa A Brake, Audrey C Cleuren, Jill M Johnsen, Amy Banes-Berceli, Fabia U Battistuzzi, Randal J Westrick
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 37
Decreased fibrinolytic activity is strongly associated with cardiovascular disease. Plasminogen activator inhibitor-1, (PAI-1, Serpine1) is a major circulating fibrinolysis inhibitor, >80% of which is found in platelets. Platelet PAI-1 (pPAI-1) is pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4be93c1e10227eee42dc72bd54cac4a
https://doi.org/10.1161/atvb.37.suppl_1.31
https://doi.org/10.1161/atvb.37.suppl_1.31
Autor:
Guojing Zhu, Amy E Siebert, Marisa A Brake, Alexander J Johnston, Cleuren Audrey, Randal J. Westrick, Linzi M Hobbs, Vakharia Paras
Publikováno v:
Blood. 134:2340-2340
Venous thromboembolism (VTE) is a prevalent human disease that exhibits significant heritability. Factor V Leiden (F5L) is the most common known VTE risk factor, but modifier genes significantly influence VTE development. We recently identified a p.R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ff6c41add05a50a8d445dbe661f40e0
https://doi.org/10.1182/blood-2019-131004
https://doi.org/10.1182/blood-2019-131004