Exenatide once weekly over 2 years as a potential disease-modifying treatment for Parkinson’s disease: protocol for a multicentre, randomised, double blind, parallel group, placebo controlled, phase 3 trial: The ‘Exenatide-PD3’ study

Autor: Thomas Foltynie, Rachael Hunter, Lynn Rochester, Dilan Athauda, Patricia Limousin, Alexa King, Simon Skene, Kashfia Chowdhury, Camille B Carroll, Huw Morris, Michele T Hu, Monty Silverdale, Rachel Gibson, Marisa Chau, Christine Lo, Nirosen Vijiaratnam, Christine Girges, Grace Auld, Kate Maclagan, Steve Hibbert, Gordon W Duncan, Ray Chaudhuri, Silvia Del Din, Alison J Yarnall, John Dickson, Vincenzo Libri

Publikováno v: BMJ Open, Vol 11, Iss 5 (2021)

Introduction Parkinson’s disease (PD) is a common neurodegenerative disorder with substantial morbidity. No disease-modifying treatments currently exist. The glucagon like peptide-1 receptor agonist exenatide has been associated in single-centre st

Externí odkaz: https://doaj.org/article/747e573c62344e5b81c9220c10131898

Evaluation of a targeted, theory-informed implementation intervention designed to increase uptake of emergency management recommendations regarding adult patients with mild traumatic brain injury: results of the NET cluster randomised trial

Autor: Marije Bosch, Joanne E. McKenzie, Jennie L. Ponsford, Simon Turner, Marisa Chau, Emma J. Tavender, Jonathan C. Knott, Russell L. Gruen, Jill J. Francis, Sue E. Brennan, Andrew Pearce, Denise A. O’Connor, Duncan Mortimer, Jeremy M. Grimshaw, Jeffrey V. Rosenfeld, Susanne Meares, Tracy Smyth, Susan Michie, Sally E. Green

Publikováno v: Implementation Science, Vol 14, Iss 1, Pp 1-16 (2019)

Abstract Background Evidence-based guidelines for management of mild traumatic brain injury (mTBI) in the emergency department (ED) are now widely available; however, clinical practice remains inconsistent with these guidelines. A targeted, theory-in

Externí odkaz: https://doaj.org/article/4f19437c9a0744fa9659beb5322ad1b5

Factors associated with persistent post-concussion symptoms following mild traumatic brain injury in adults

Autor: Jennifer Ponsford, Sylvia Nguyen, Marina Downing, Marije Bosch, Joanne E. McKenzie, Simon Turner, Marisa Chau, Duncan Mortimer, Russell L. Gruen, Jonathan Knott, Sally Green

Publikováno v: Journal of Rehabilitation Medicine, Vol 51, Iss 1, Pp 32-39 (2018)

Objectives: Debate regarding factors associated with persistent symptoms following mild traumatic brain injury continues. Nested within a trial aiming to change practice in emergency department management of mild traumatic brain injury, this study in

Externí odkaz: https://doaj.org/article/cc5b1b7358e74ab482d4f802b92993ee

Optimal timing of anticoagulation after acute ischemic stroke with atrial fibrillation (OPTIMAS): Protocol for a randomized controlled trial

Autor: Jonathan G, Best, Liz, Arram, Norin, Ahmed, Maryam, Balogun, Kate, Bennett, Ekaterina, Bordea, Marta G, Campos, Emilia, Caverly, Marisa, Chau, Hannah, Cohen, Hakim-Moulay, Dehbi, Caroline J, Doré, Stefan T, Engelter, Robert, Fenner, Nick, Freemantle, Rachael, Hunter, Martin, James, Gregory Yh, Lip, Macey L, Murray, Bo, Norrving, Nikola, Sprigg, Roland, Veltkamp, Iwona, Zaczyk, David J, Werring

Publikováno v: Best, J G, Arram, L, Ahmed, N, Balogun, M, Bennett, K, Bordea, E, Campos, M G, Caverly, E, Chau, M, Cohen, H, Dehbi, H-M, Doré, C J, Engelter, S T, Fenner, R, Freemantle, N, Hunter, R, James, M, Lip, G YH, Murray, M L, Norrving, B, Sprigg, N, Veltkamp, R, Zaczyk, I, Werring, D J & OPTIMAS investigators 2022, ' Optimal timing of anticoagulation after acute ischemic stroke with atrial fibrillation (OPTIMAS) : Protocol for a randomized controlled trial ', International Journal of Stroke, vol. 17, no. 5, pp. 583-589 . https://doi.org/10.1177/17474930211057722

Rationale Atrial fibrillation causes one-fifth of ischemic strokes, with a high risk of early recurrence. Although long-term anticoagulation is highly effective for stroke prevention in atrial fibrillation, initiation after stroke is usually delayed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::958f7d1b2a3336860b9ffb15ccefaa07
https://pubmed.ncbi.nlm.nih.gov/35018878

Perioperative Anemia Management

Autor: Marisa Chau, Sandaruwani Abeysiri, Toby Richards

Publikováno v: Seminars in Thrombosis and Hemostasis. 46:008-016

Anemia is increasingly recognized as an interventional hematological target in patients before major surgery. Preoperative anemia increases the need for perioperative blood transfusion, and there is now a well-recognized association with increased pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f23de4725ca874881603f7b8e159f0
https://doi.org/10.1055/s-0039-1697933