Výsledky vyhledávání - "Marion v Guerin"

Akademický článek

Local IFNα enhances the anti-tumoral efficacy of systemic anti-PD1 to prevent tumor relapse

Autor: Maxime Thoreau, Fabienne Regnier, Ludger Johannes, Estelle Dransart, Alain Trautmann, Nadege Bercovici, Marion v Guerin, Lene Vimeux, Matthieu Benard, Hweixian L Penny

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

Background Tumor relapse constitutes a major challenge for anti-tumoral treatments, including immunotherapies. Indeed, most cancer-related deaths occur during the tumor relapse phase.Methods We designed a mouse model of tumor relapse in which mice tr

Externí odkaz: https://doaj.org/article/eb416a1a1ddb4c35877b667537985dcb

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Akademický článek

Preclinical murine tumor models: A structural and functional perspective

Autor: Marion V Guerin, Veronica Finisguerra, Benoit J Van den Eynde, Nadege Bercovici, Alain Trautmann

Publikováno v: eLife, Vol 9 (2020)

The goal of this review is to pinpoint the specific features, including the weaknesses, of various tumor models, and to discuss the reasons why treatments that are efficient in murine tumor models often do not work in clinics. In a detailed compariso

Externí odkaz: https://doaj.org/article/d5ab3c076e0d48109f303049d9abc1ad

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Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity

Autor: Morgane Boulch, Marine Cazaux, Alexis Cuffel, Marion V. Guerin, Zacarias Garcia, Ruby Alonso, Fabrice Lemaître, Alexander Beer, Béatrice Corre, Laurie Menger, Capucine L. Grandjean, Florence Morin, Catherine Thieblemont, Sophie Caillat-Zucman, Philippe Bousso

Publikováno v: Nature Cancer
Nature Cancer, 2023, ⟨10.1038/s43018-023-00570-7⟩

CD4+ T cells and CD4+ chimeric antigen receptor (CAR) T cells display highly variable antitumor activity in preclinical models and in patients; however, the mechanisms dictating how and when CD4+ T cells promote tumor regression are incompletely unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee8211ffd4eb62019b8b82a7a399412
https://hal-pasteur.archives-ouvertes.fr/pasteur-04158305

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TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors

Autor: Emmanuel Donnadieu, Thomas Guilbert, Vincent Feuillet, Fabienne Regnier, Maxime Thoreau, Veronica Finisguerra, Alain Trautmann, Lene Vimeux, Nadège Bercovici, Julia Miriam Weiss, Marion V. Guerin, Gilles Renault

Publikováno v: Nature Communications
Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-019-11998-w⟩
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-11998-w⟩
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

Type I interferons (IFN) are being rediscovered as potent anti-tumoral agents. Activation of the STimulator of INterferon Genes (STING) by DMXAA (5,6-dimethylxanthenone-4-acetic acid) can induce strong production of IFNα/β and rejection of transpla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e17412bd5ea94db5b6ff7a7d04c5eb2
https://hal.archives-ouvertes.fr/hal-02404270

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Akademický článek

TGFβ blocks IFNα/β release and tumor rejection in spontaneous mammary tumors

Autor: Marion V. Guerin, Fabienne Regnier, Vincent Feuillet, Lene Vimeux, Julia M. Weiss, Georges Bismuth, Gregoire Altan-Bonnet, Thomas Guilbert, Maxime Thoreau, Veronica Finisguerra, Emmanuel Donnadieu, Alain Trautmann, Nadège Bercovici

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

Interferons have been shown to mediate tumour rejection. Here, in a spontaneous mouse model of breast cancer, the authors show that this is disrupted owing to high levels of TGFβ produced in the tumour.

Externí odkaz: https://doaj.org/article/4998cfedc6d240aeaec2f8249ea1a3ed

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