Výsledky vyhledávání - "Marion Zerlin"

Allosteric sensitization of nicotinic receptors by galantamine, a new treatment strategy for Alzheimer’s disease

Autor: Marek Samochocki, Alfred Maelicke, Jürgen Ludwig, Ruth Jostock, Andreas Fehrenbacher, Edson X Albuquerque, Marion Zerlin

Publikováno v: Biological Psychiatry. 49:279-288

Cholinesterase inhibitors are the only approved drug treatment for patients with mild to moderately severe Alzheimer's disease. Interestingly, the clinical potency of these drugs does not correlate well with their activity as cholinesterase inhibitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa537690180d9f577a6edc6e6e2e7b49
https://doi.org/10.1016/s0006-3223(00)01109-4

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Galantamine is an allosterically potentiating ligand of the human α4/β2 nAChR

Autor: Alfred Maelicke, Marion Zerlin, Marek Samochocki, Walter Luyten, Edson X. Albuquerque, P. J. Groot Kormelink, Ruth Jostock

Publikováno v: Acta Neurologica Scandinavica. 102:68-73

Galantamine (ReminyI ) is a novel drug treatment for mild to moderate Alzheimer's disease (AD). Originally established as a reversible inhibitor of the acetylcholine-degrading enzyme acetylcholinesterase (AChE), galantamine also acts as an allosteric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0163457547460380a617b1d1ddae3656
https://doi.org/10.1034/j.1600-0404.2000.00310.x

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Biomolecular-chemical Screening. A Novel Screening Approach for the Diseovery of Biologically Active Seeondary Metabolites. III. New DNA-binding Metabolites

Autor: Marion Zerlin, Claudia Hinze, Ralf Thiericke, Armin Maier, Corinna Maul, Isabel Sattler, Corinna Koch, Susanne Grabley

Publikováno v: The Journal of Antibiotics. 52:1124-1134

Based on the chemical screening technique, biomolecular-chemical screening has been developed which makes use of two-dimensional TLC analysis of microbial extracts and combines thin-layer chromatography (RP-18) with binding studies towards DNA. In th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0da34dc262ed73fdd510728c655875e
https://doi.org/10.7164/antibiotics.52.1124

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First Glycosylation of Decarestrictine B and D: A Route to Hybrid Antibiotics

Autor: Corinna Maul, Alfons Garming, Marion Zerlin, Andreas Kirschning, Mathias Noltemeyer, Ralf Thiericke, Gerald Dräger

Publikováno v: Chemistry - A European Journal. 4:1324-1333

A set of new hybrid antibiotics can be generated by coupling the naturally occurring ten-membered lactones decarestrictine B and D, which lower cholesterol levels, with deoxygenated glycosyl donors. As demonstrated for bisglycoside 1 these novel glyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::984aa6fb0834d3dea09a3969426ddf38
https://doi.org/10.1002/(sici)1521-3765(19980710)4:7<1324::aid-chem1324>3.0.co

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Manipulation of Microbial Metabolite Pattern, 2. Initiation of Streptovaricine and Tryptophan-Dehydrobutyrin-Diketopiperazine Biosynthesis in a Marginolactone-Producing Actinomycetes Strain

Autor: Marion Zerlin, Axel Zeeck, Petra Henne, Ralf Thiericke

Publikováno v: Natural Product Letters. 10:217-224

Manipulation of the secondary metabolite pattern was studied by feeding various amino acids into cultures of the ‘talented’ Streptomyces sp. (strain FH-S 1623), which already has been found to produce marginolactones (oasomycins A to F, as well a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8fee15a35c56abdfb8c37a7f3f364140
https://doi.org/10.1080/10575639708041198

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Lipohexin, a New Inhibitor of Prolyl Endopeptidase from Moeszia lindtneri (HKI-0054) and Paecilomyces sp. (HKI-0055; HKI-0096). I. Screening, Isolation and Structure Elucidation

Autor: Werner F. Fleck, Heike Hülsmann, Udo Gräfe, Stephan Heinze, Gunter Fischer, Wolfgang Ihn, Gerhard Küllertz, Klausjürgen Dornberger, Michael Ritzau, Marion Zerlin, Claudia Christner, Brigitte Schlegel

Publikováno v: The Journal of Antibiotics. 50:379-383

Lipohexin was isolated as a novel lipohexapeptide (I) (C39H68N6O9) from three fungal strains, Moeszia lindtneri HKI-0054, Paecilomyces sp. HKI-0055 and Paecilomyces sp. HKI-0096. The structure was elucidated by detailed mass spectrometric and NMR exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6d561823a05b3f0336e2bba094b5f12
https://doi.org/10.7164/antibiotics.50.379

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Manipulation of Microbial Metabolite Pattern. 1. Initiation of Obscurolide Biosynthesis in a Streptozoline-producing Streptomycetes Strain

Autor: Marion Zerlin, Ralf Thiericke

Publikováno v: Natural Product Letters. 8:163-167

Manipulation of the secondary metabolite pattern was studied by feeding various compounds into growing cultures of the streptazolin (1)-producing organism Streptomyces sp. (strain FH-S 2184). Besides an increase of the yield of (1),caused by a number

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe1a7be0625b7dade98f7fd0740293b5
https://doi.org/10.1080/10575639608044889

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