Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Marion T, Kasaian"'
Autor:
Scott A Jelinsky, Merel Derksen, Eric Bauman, Carla S Verissimo, Wies T M van Dooremalen, Jamie Lee Roos, Celia Higuera Barón, Celia Caballero-Franco, Bryce G Johnson, Michelle G Rooks, Johanna Pott, Bas Oldenburg, Robert G J Vries, Sylvia F Boj, Marion T Kasaian, Farzin Pourfarzad, Charles V Rosadini
Publikováno v:
Inflammatory bowel diseases.
Background Patient-derived organoid (PDO) models offer potential to transform drug discovery for inflammatory bowel disease (IBD) but are limited by inconsistencies with differentiation and functional characterization. We profiled molecular and cellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f32b4dc5502df57f0facfdee5d71ce9
https://pubmed.ncbi.nlm.nih.gov/36356046
https://pubmed.ncbi.nlm.nih.gov/36356046
Autor:
Thiago A. Pereira, Richard L. Gieseck, Marion T. Kasaian, Trisha S. Pasricha, Fang Jin, Lioudmila Tchistiakova, Farmer Mark A, Robert W. Thompson, Kayla J. Knilans, Nan Bing, Thomas A. Wynn, Rafael de Queiroz Prado, Kevin M. Vannella, Aaron Kleinman, Thirumalai R. Ramalingam, Martin Hegen, David A. Hinds, Erik P. Karmele
Publikováno v:
Mucosal immunology
There continues to be a major need for more effective inflammatory bowel disease (IBD) therapies. IL-13Rα2 is a decoy receptor that binds the cytokine IL-13 with high affinity and diminishes its STAT6-mediated effector functions. Previously, we foun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::390071265a9c9d2f4c1c4ce7feccc730
https://doi.org/10.1038/s41385-019-0189-6
https://doi.org/10.1038/s41385-019-0189-6
Publikováno v:
Advances in Therapy
Progressive multifocal leukoencephalopathy (PML) is a rare but serious disease. Caused by the JC virus (JCV), it occurs in individuals with weakened immune systems and is a potential adverse reaction for certain immunomodulatory drugs. The PML Consor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c92c54f2233828b2f1e303b2695085
https://doi.org/10.1007/s12325-019-0886-2
https://doi.org/10.1007/s12325-019-0886-2
Autor:
Marion T. Kasaian, A. David Rodrigues, Regis Doyonnas, Bhagwat Prasad, Aarti Sawant-Basak, Matthew P. Lech, Nikolaos Tsamandouras
Publikováno v:
Drug Metabolism and Disposition. 46:1581-1587
Intestinal disposition of small molecules involves interplay of drug metabolizing enzymes (DMEs), transporters, and host-microbiome interactions, which has spurred the development of in vitro intestinal models derived from primary tissue sources. Suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464ef4e1f658fa92c87a9b63b21bd5a0
https://doi.org/10.1124/dmd.118.082784
https://doi.org/10.1124/dmd.118.082784
Autor:
Marion T. Kasaian, Jeffrey Morin, Melvin Zhang, Jennifer Parker Duffen, Jessica E. C. Jones, Angela Nunez, Agnes Brennan, Karl Nocka, Katherine Masek-Hammerman
Publikováno v:
The Journal of Immunology. 200:1347-1359
In obesity, IL-13 overcomes insulin resistance by promoting anti-inflammatory macrophage differentiation in adipose tissue. Endogenous IL-13 levels can be modulated by the IL-13 decoy receptor, IL-13Rα2, which inactivates and depletes the cytokine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a4e038631ca2d0d98be508f407879fe
https://doi.org/10.4049/jimmunol.1701256
https://doi.org/10.4049/jimmunol.1701256
Autor:
K. E. Black, S. I. Danto, Marion T. Kasaian, A. E. Dixon, Julie Lee, Agnes Brennan, Lori Fitz
Publikováno v:
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 48(7)
Background A major goal of asthma therapy is to achieve disease control, with maintenance of lung function, reduced need for rescue medication, and prevention of exacerbation. Despite current standard of care, up to 70% of patients with asthma remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f125b1c8d9add469f1201afe58abe51
https://pubmed.ncbi.nlm.nih.gov/29665127
https://pubmed.ncbi.nlm.nih.gov/29665127
Autor:
Paresh Thakker, Melvin Zhang, Susan Fish, Karen Betancourt Moreira, Julie Lee, Rita Agostinelli, Marion T. Kasaian, Kimberly Ann Marquette, Lioudmila Tchistiakova, Timothy A. Cook, Michael I. Jesson, Agnes Brennan, Cara M. M. Williams, Karen Page
Publikováno v:
Immunology. 143:416-427
Interleukin-4 (IL-4) and IL-13 are critical drivers of immune activation and inflammation in ulcerative colitis, asthma and other diseases. Because these cytokines may have redundant function, dual targeting holds promise for achieving greater effica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a45b0576e9e8ace3cb2513d9ff40f2
https://doi.org/10.1111/imm.12319
https://doi.org/10.1111/imm.12319
Publikováno v:
mAbs. 8(5)
IMA-638 and IMA-026 are humanized IgG1 monoclonal antibodies (mAbs) that target non-overlapping epitopes of IL-13. Separate first-in-human single ascending dose studies were conducted for each mAb. These studies had similar study designs, but mild to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e21f5c6638762a668750ecb7f0b5330
https://pubmed.ncbi.nlm.nih.gov/27049478
https://pubmed.ncbi.nlm.nih.gov/27049478
Autor:
Davinder Gill, William Brady, Stephane Olland, Neil M. Wolfman, Marion T. Kasaian, Cheryl Nickerson-Nutter, Richard Zollner, Mary Collins, David Wensel, Kyri Dunussi-Joannopoulos, Yulia Vugmeyster, Deborah Herber, Lioudmila Tchistiakova, Kendall M. Mohler, Barbara Sibley, Alan Wahl, Nilufer P. Seth, Peter Robert Baum
Publikováno v:
Rheumatology (Oxford, England)
Objectives. To characterize the in vitro binding and effector function properties of CD20-directed small modular immunopharmaceutical (SMIP) 2LM20-4, and to compare its in vivo B-cell depletion activity with the mutated 2LM20-4 P331S [no in vitro com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9be82997f594d17401bdc27fc75152
http://europepmc.org/articles/PMC3093928
http://europepmc.org/articles/PMC3093928
Autor:
John Todd, Ole E Vesterqvist, Jennifer Minyard, Marion T. Kasaian, Katie St. Ledger, Stephen B. Forlow, Sara J. Agee, Michael E. Burczynski, Quynh Anh Lu, Billie Durn
Publikováno v:
Journal of Immunological Methods. 350:161-170
IL-13 is a Th2 cytokine that has been shown to be an important mediator of airway inflammation contributing to asthma lesions. Given its proposed role in asthma, measurements of this cytokine in serum may provide insights into disease mechanisms, pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5460c99d3cf8c0342fe4bcc6f619f89f
https://doi.org/10.1016/j.jim.2009.08.012
https://doi.org/10.1016/j.jim.2009.08.012