Prefrontal cortex molecular clock modulates development of depression-like phenotype and rapid antidepressant response in mice

Autor: David H. Sarrazin, Wilf Gardner, Carole Marchese, Martin Balzinger, Chockalingam Ramanathan, Marion Schott, Stanislav Rozov, Maxime Veleanu, Stefan Vestring, Claus Normann, Tomi Rantamäki, Benedicte Antoine, Michel Barrot, Etienne Challet, Patrice Bourgin, Tsvetan Serchov

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Depression is associated with dysregulated circadian rhythms, but the role of intrinsic clocks in mood-controlling brain regions remains poorly understood. We found increased circadian negative loop and decreased positive clock regulators ex

Externí odkaz: https://doaj.org/article/9ad37719675c46fd819632ea2e129ebf

Role of the striatal dopamine, GABA and opioid systems in mediating feeding and fat intake

Autor: Anil Joshi, Marion Schott, Susanne Eva la Fleur, Michel Barrot

Publikováno v: Neuroscience and Biobehavioral Reviews, 139. Elsevier B.V.
Neuroscience and Biobehavioral Reviews
Neuroscience and Biobehavioral Reviews, 2022, 139, pp.104726. ⟨10.1016/j.neubiorev.2022.104726⟩

Food intake, which is a highly reinforcing behavior, provides nutrients required for survival in all animals. However, when fat and sugars consumption goes beyond the daily needs, it can favor obesity. The prevalence and severity of this health probl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c01f521e32b0b86626714af5796fa6
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