The downregulation of Kv1 channels in Lgi1−/− mice is accompanied by a profound modification of its interactome and a parallel decrease in Kv2 channels

Autor: Jorge Ramirez-Franco, Kévin Debreux, Marion Sangiardi, Maya Belghazi, Yujin Kim, Suk-Ho Lee, Christian Lévêque, Michael Seagar, Oussama El Far

Publikováno v: Neurobiology of Disease, Vol 196, Iss , Pp 106513- (2024)

In animal models of LGI1-dependent autosomal dominant lateral temporal lobe epilepsy, Kv1 channels are downregulated, suggesting their crucial involvement in epileptogenesis. The molecular basis of Kv1 channel-downregulation in LGI1 knock-out mice ha

Externí odkaz: https://doaj.org/article/2e7ee02f8fec4a0aa115a578527a6516

Molecular landscape of BoNT/B bound to a membrane-inserted synaptotagmin/ganglioside complex

Autor: Jorge Ramirez-Franco, Fodil Azzaz, Marion Sangiardi, Géraldine Ferracci, Fahamoe Youssouf, Michel Robert Popoff, Michael Seagar, Christian Lévêque, Jacques Fantini, Oussama El Far

Publikováno v: Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, 2022, 79 (9), pp.496. ⟨10.1007/s00018-022-04527-4⟩

International audience; Botulinum neurotoxin serotype B (BoNT/B) uses two separate protein and polysialoglycolipid-binding pockets to interact with synaptotagmin 1/2 and gangliosides. However, an integrated model of BoNT/B bound to its neuronal recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d2f4bb309d656f914aa9f1bcac9eb7
https://pubmed.ncbi.nlm.nih.gov/36006520

Patient-derived recombinant autoantibodies reveal the subcellular neuroglial distribution and heterogeneous interactome of leucine-rich glioma-inactivated 1

Autor: Jorge Ramirez-Franco, Kévin Debreux, Johanna Extremet, Yves Maulet, Maya Belghazi, Claude Villard, Marion Sangiardi, Fahamoe Youssouf, Lara El Far, Christian Lévêque, Claire Debarnot, Pascale Marchot, Sofija Paneva, Dominique Debanne, Michael Russier, Michael Seagar, Sarosh R Irani, Oussama El Far

Autoantibodies against leucine-rich glioma-inactivated 1 (LGI1) occur in patients with encephalitis who present with frequent focal seizures and a pattern of amnesia consistent with focal hippocampal damage. To investigate whether the cellular and su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46b7a577bd302c4ec0743f8baca25c26
https://doi.org/10.1101/2022.03.29.486232

Chromophore-Assisted Light Inactivation of the V-ATPase V0c Subunit Inhibits Neurotransmitter Release Downstream of Synaptic Vesicle Acidification

Autor: Dominique Debanne, Oussama El Far, Yves Maulet, Sylvain Rama, Christian Lévêque, Fahamoe Youssouf, Michael Seagar, Norah Boumedine-Guignon, Marion Sangiardi, Maya Belghazi

Publikováno v: Molecular Neurobiology
Molecular Neurobiology, Humana Press, 2019, 56 (5), pp.3591-3602. ⟨10.1007/s12035-018-1324-1⟩
Molecular Neurobiology, 2019, 56 (5), pp.3591-3602. ⟨10.1007/s12035-018-1324-1⟩

International audience; Synaptic vesicle proton V-ATPase is an essential component in synaptic vesicle function. Active acidification of synaptic vesicles, triggered by the V-ATPase, is necessary for neurotransmitter storage. Independently from its p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb57ad10c24eee92d5311388dfdb3fd1
https://www.hal.inserm.fr/inserm-01878772/document

LGI1 tunes intrinsic excitability by regulating the density of axonal Kv1 channels

Autor: Léa Rodriguez, Fabrice Usseglio, Michaël Russier, Morgane Boillot, Fahamoe Youssouf, Norah Boumedine-Guignon, Mickaël Zbili, Christine Formisano-Tréziny, Michael Seagar, María J. Benítez, Marion Sangiardi, Laure Fronzaroli-Molinieres, Stéphanie Baulac, Olivier Caillard, Juan José Garrido, Yves Maulet, Marina De San Feliciano, Dominique Debanne, Oussama El Far

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2017, 114 (29), pp.7719-7724. ⟨10.1073/pnas.1618656114⟩
Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (29), pp.7719-7724. ⟨10.1073/pnas.1618656114⟩
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© The Author(s).
Autosomal dominant epilepsy with auditory features results from mutations in leucine-rich glioma-inactivated 1 (LGI1), a soluble glycoprotein secreted by neurons. Animal models of LGI1 depletion display spontaneous seizures, ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f623ed8dbbc0511470554df8022dc0f5
https://www.hal.inserm.fr/inserm-01708767