Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Marion R. Steiner"'
Autor:
Mark P. Mattson, Sheldon M. Steiner, Jeffrey N. Keller, Marion R. Steiner, Frederick W. Holtsberg
Publikováno v:
Annals of the New York Academy of Sciences. 905:132-141
Lysophosphatidic acid (LPA) elicits a unique response in primary hippocampal neurons and sympathetic neuron-like cells, PC12 cells differentiated with nerve growth factor; LPA is cytotoxic. Treatment of rat hippocampal neurons with 50 microM LPA resu
Autor:
James M. Hill, Will R Allen, Marion R. Steiner, Craig S. Miller, Robert J. Jacob, Robert J. Danaher
Publikováno v:
Journal of Neurovirology. 11:306-317
Histone acetylation is implicated in the regulation of herpes simplex virus type 1 (HSV-1) latency. However, the role of histone acetylation in HSV-1 reactivation is less clear. In this study, the well-established model system, quiescently infected,
Autor:
Jeffrey N. Keller, Mark P. Mattson, Frederick W. Holtsberg, Robert J. Mark, Sheldon M. Steiner, Marion R. Steiner
Publikováno v:
Journal of Neurochemistry. 70:66-76
A diverse body of evidence indicates a role for the lipid biomediator lysophosphatidic acid (LPA) in the CNS. This study identifies and characterizes the induction of neuronal death by LPA. Treatment of cultured hippocampal neurons from embryonic rat
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1582:154-160
Lysophosphatidic acid (LPA) and LPA receptors are enriched in the brain. Moreover, the levels of these receptors and ligand are modulated during brain development and injury, respectively, suggesting multiple roles for LPA in the brain. In cultured a
Autor:
Mike A. Clark, John S. Bomalaski, Frederick W. Holtsberg, Charles Mark Ensor, Marion R. Steiner
Publikováno v:
Journal of Controlled Release. 80:259-271
Some tumors, such as melanomas and hepatocellular carcinomas, have a unique nutritional requirement for arginine. Thus, enzymatic degradation of extracellular arginine is one possible means for inhibiting these tumors. Arginine deiminase is an argini
Autor:
Frederick W. Holtsberg, Mark P. Mattson, Jeffrey N. Keller, Annadora J. Bruce-Keller, Marion R. Steiner, John C. Moyers, Sheldon M. Steiner
Publikováno v:
Journal of Neuroscience Research. 53:685-696
The lipid biomediator lysophosphatidic acid (LPA) elicits a unique response in hippocampal neurons, LPA induces neuronal apoptosis. This study explores the effects of LPA on cells with neuronal properties, nerve growth factor-differentiated PC6 cells
Publikováno v:
Experimental Cell Research. 218:389-393
Exponentially growing DD-1 cells (differentiation-defective cells) synthesize prostaglandins, while exponentially growing MyoDD-1 cells (differentiation-competent cells; DD-1 cells transfected with the myogenic regulatory gene MyoD) synthesize little
Publikováno v:
Cancer Letters. 86:11-21
Phospholipase A2 (PLA2) activities of non-tumorigenic and tumorigenic human mammary epithelial cells, 184B5 cells (immortalized cell line from a reduction mammoplasty) and B5KTu cells (cells from a tumor induced by ras-transformed 184B5 cells), are c
Publikováno v:
Brain Research. 654:171-176
Recent findings indicate that amyloid beta-peptide (A beta) can be neurotoxic by a mechanism involving an increase in the concentration of intracellular free Ca2+ ([Ca2+]i) and the generation of free radicals. In the present study, the lipoxygenase i
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1166:124-130
The role of the phospholipase A2 (PLA2) stimulating protein PLAP in the regulation of PLA2 activity was assessed by determination of the effects of PLAP on two purified PLA2s. An approx. 14 kDa enzyme was purified from mouse thymoma cells, EL-4 cells